Parasystole

A cardiac arrhythmia that is caused by interaction of two independently initiated cardiac impulses of different rates from two separate foci. Generally one focus is the SINOATRIAL NODE, the normal pacemaker. The ectopic focus is usually in the HEART VENTRICLE but can be in the HEART ATRIUM or the ATRIOVENTRICULAR NODE. Modulation of the parasystolic rhythm by the sinus rhythm depends on the completeness of entrance block surrounding the parasystolic focus.

Synonym
Parasystole

Excerpt	Reference
"Parasystole is usually an extrasystolic rhythm which can occur at every level, but particularly in the ventricle."	( Grolleau, R; Leclercq, F; Macia, JC; Pasquié, JL, 2002)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	4 (40.00)	23.3326
1990's	3 (30.00)	12.5806
2000's	2 (20.00)	18.1394
2010's	1 (10.00)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies	Trials
verapamil	low	1	0
methylphenidate	low	1	0
riluzole	medium	1	1
thalidomide	medium	1	1
sucrose	low	1	0
adenosine	low	1	0
atropine	low	2	0
quinidine	low	1	0
digitoxin	low	1	0

Protein Targets (309)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	7	0	0	7
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	3	0	0	3
glucocorticoid receptor [Homo sapiens]	6	0	0	6
retinoid X nuclear receptor alpha	4	0	0	4
estrogen nuclear receptor alpha	7	0	0	7
NPYLR7B	0	0	1	1
arylsulfatase A	3	0	0	3
IDH1	3	0	0	3
Histone H2A.x	2	0	0	2
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	1	0	0	1
flap endonuclease 1	2	0	0	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
peripheral myelin protein 22	3	0	0	3
survival motor neuron protein isoform d	2	0	0	2
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Rap guanine nucleotide exchange factor 3	1	0	0	1
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	2	2	5
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Glutamate receptor 2	3	0	0	3
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	1	1	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	1	2	4
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	2	5
Adenosine receptor A2a	0	1	1	2
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
GLI family zinc finger 3	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
pregnane X nuclear receptor	6	0	0	6
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	1	0	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	5	0	6
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	5
5-hydroxytryptamine receptor 4	0	4	0	4
Bile salt export pump	0	6	0	6
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M1	0	2	1	5
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M2	0	2	1	6
Muscarinic acetylcholine receptor M1	0	2	1	6
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	2	1	5
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	4
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	1	0	0	2
5-hydroxytryptamine receptor 7	0	3	0	3
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	5	0	5
Chain A, Beta-lactamase	2	0	0	2
Chain A, Cruzipain	1	0	0	1
acetylcholinesterase	1	0	0	1
RAR-related orphan receptor gamma	3	0	0	3
SMAD family member 2	2	0	0	2
ATAD5 protein, partial	2	0	0	2
SMAD family member 3	2	0	0	2
TDP1 protein	4	0	0	4
Microtubule-associated protein tau	1	0	0	1
STAT3, partial	0	1	0	1
Smad3	1	0	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
progesterone receptor	2	0	0	2
estrogen-related nuclear receptor alpha	3	0	0	3
farnesoid X nuclear receptor	2	0	0	2
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
thyroid stimulating hormone receptor	2	0	0	2
activating transcription factor 6	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
thyroid hormone receptor beta isoform a	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
thyroid hormone receptor beta isoform 2	4	0	0	4
ras-related protein Rab-9A	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
geminin	3	0	0	3
lamin isoform A-delta10	3	0	0	3
Interferon beta	3	0	0	3
Cellular tumor antigen p53	2	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	3	0	0	3
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
glp-1 receptor, partial	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
cytochrome P450 2D6	2	0	0	2
aryl hydrocarbon receptor	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Histidine-rich protein PFHRP-II	0	1	0	1
Cholinesterase	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	4	1	13
Cytochrome P450 3A4	0	3	0	3
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2C9	0	3	0	3
Cytochrome P450 2D3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
UDP-glucuronosyltransferase 2B7	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
UDP-glucuronosyltransferase 1-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
ATP-dependent translocase ABCB1	0	2	0	3
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Spike glycoprotein	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Cholinesterase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Sodium channel protein type 5 subunit alpha	0	2	0	2
Solute carrier family 22 member 1	0	2	0	3
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
Multidrug resistance protein 1a	0	0	0	1
GABA theta subunit	2	0	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
Solute carrier family 22 member 2	0	2	0	2
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Luciferase	1	0	0	1
thioredoxin reductase	2	0	0	2
15-lipoxygenase, partial	1	0	0	1
USP1 protein, partial	1	0	0	1
NFKB1 protein, partial	1	0	0	1
EWS/FLI fusion protein	3	0	0	3
nonstructural protein 1	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
G	2	0	0	2
Parkin	1	0	0	1
pyruvate kinase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
Bloom syndrome protein isoform 1	2	0	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
chromobox protein homolog 1	1	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
pyruvate kinase PKM isoform b	1	0	0	1
Potassium channel subfamily K member 2	0	0	1	1
Dihydrofolate reductase	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Integrin beta-3	1	0	0	1
Cytochrome P450 1A2	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Integrin alpha-IIb	1	0	0	1
Ornithine decarboxylase	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Cytochrome P450 2C19	0	1	0	1
Alpha-synuclein	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Pteridine reductase 1	0	2	0	2
TAR DNA-binding protein 43	1	0	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
cytochrome P450 2C9, partial	2	0	0	2
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Carbonic anhydrase 2	0	1	1	2
Carbonic anhydrase 9	0	1	1	2
Cereblon isoform 4	0	2	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	2	0	0	2
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
glucocerebrosidase	1	0	0	1
huntingtin isoform 2	1	0	0	1
Bile salt export pump	0	1	0	1
Albumin	0	0	1	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Alpha-2A adrenergic receptor	0	2	0	2
Cytochrome P450 2C8	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Multidrug resistance-associated protein 1	0	2	1	4
Mu-type opioid receptor	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Cytochrome P450 2J2	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Research

Studies (10)

Protein Targets (309)

Parasystole

Synonyms(1)

Research Excerpts

Overview

Research

Studies (10)

Drugs Studied (12)

Protein Targets (309)