Fibroma, Ossifying

A benign central bone tumor, usually of the jaws (especially the mandible), composed of fibrous connective tissue within which bone is formed.

Synonyms(1)

Synonym
Fibroma, Ossifying

Research Excerpts

Overview

Excerpt	Reference
"Ossifying fibroma is a benign fibro-osseous tumor, rarely involving the anterior cranial base."	( Ito, Y; Nakagawa, K; Takasato, Y; Yamada, K, 1995)
"The ossifying fibroma is a rare manifestation."	( Benghanem, MG; Fatihi, E; Hachim, K; Lemseffer, A; Ramdani, B; Rochdi, R; Zahiri, K; Zaïd, D, 2003)
"An ossifying fibroma is associated with significant cosmetic and functional disturbances, as it shows expansive proliferation."	( Hatano, H; Higashikawa, K; Kamata, N; Kudo, Y; Ogawa, I; Ohta, K; Shigeishi, H; Takata, T; Takechi, M, 2013)
"Sinonasal ossifying fibroma is rare and frequently occurs in young adulthood with a female predominance."	( Shen, J; Tan, J; Wang, J; Xia, S; Zhang, R, 2016)
"Ossifying fibromas are mainly found in the mandible and maxilla."	( Addison, A; Beigi, B; Philpott, C; Ta, NH, 2019)

Research

Studies (57)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	6 (10.53)	23.3326
1990's	4 (7.02)	12.5806
2000's	16 (28.07)	18.1394
2010's	23 (40.35)	28.8240
2020's	8 (14.04)	9.53

Drug	Relationship Strength	Studies
salicylic acid	low	2
durapatite	low	1
carbonates	low	1
silver	low	1
titanium	low	2
gadolinium	low	1
tricalcium phosphate	low	1
propiconazole	low	14
fluorodeoxyglucose f18	low	1
methotrexate	low	1
inositol 3-phosphate	low	2
keratan sulfate	low	1
osteoprotegerin	low	1
phenylephrine hydrochloride	low	7
gadolinium dtpa	low	2
jaw	low	9
epidermal growth factor	low	1
transforming growth factor beta	low	3
cyclin d1	low	1
technetium tc 99m medronate	low	2
chondroitin sulfates	low	1

Protein Targets (286)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	1	4
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain E, Fibrin beta chain	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
Luciferase	1	0	0	1
thioredoxin reductase	4	0	0	4
15-lipoxygenase, partial	2	0	0	2
WRN	1	0	0	1
Mcl-1	0	1	0	1
phosphopantetheinyl transferase	3	0	0	3
MPI protein	0	1	0	1
USP1 protein, partial	2	0	0	2
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
PPM1D protein	1	0	0	1
TDP1 protein	4	0	0	4
Microtubule-associated protein tau	2	0	0	2
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
hypothetical protein, conserved	1	0	0	1
regulator of G-protein signaling 4	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	1	0	0	1
G	1	0	0	1
67.9K protein	2	0	0	2
glucocerebrosidase	1	0	0	1
luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
cellular tumor antigen p53 isoform a	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
vitamin D3 receptor isoform VDRA	3	0	0	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
chromobox protein homolog 1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
DNA polymerase beta	2	0	0	2
mitogen-activated protein kinase 1	1	0	0	1
flap endonuclease 1	2	0	0	2
serine/threonine-protein kinase PLK1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	3	0	0	3
nuclear receptor ROR-gamma isoform 1	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
geminin	4	0	0	4
DNA polymerase kappa isoform 1	2	0	0	2
Vif	0	1	0	1
Tat	0	1	0	1
survival motor neuron protein isoform d	3	0	0	3
cytochrome P450 3A4 isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Pyruvate kinase PKM	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
Endothelin receptor type B	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Endothelin-1 receptor	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Histamine H2 receptor	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Inositol monophosphatase 1	1	0	0	1
GABA theta subunit	1	0	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
phosphoglycerate kinase	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
ATP-dependent phosphofructokinase	3	0	0	3
large T antigen	0	1	0	1
ATAD5 protein, partial	2	0	0	2
estrogen-related nuclear receptor alpha	4	0	0	4
Chymotrypsinogen A	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, Ferritin light chain	2	0	0	2
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
AR protein	3	0	0	3
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	2	0	0	2
progesterone receptor	2	0	0	2
EWS/FLI fusion protein	1	0	0	1
retinoid X nuclear receptor alpha	3	0	0	3
farnesoid X nuclear receptor	2	0	0	2
estrogen nuclear receptor alpha	4	0	0	4
peroxisome proliferator-activated receptor delta	2	0	0	2
peroxisome proliferator activated receptor gamma	3	0	0	3
vitamin D (1,25- dihydroxyvitamin D3) receptor	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
IDH1	2	0	0	2
Thymidylate synthase	0	1	0	1
Histone H2A.x	1	0	0	1
Bloom syndrome protein isoform 1	2	0	0	2
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
snurportin-1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	3	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
peripheral myelin protein 22	2	0	0	2
M-phase phosphoprotein 8	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
lamin isoform A-delta10	2	0	0	2
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	1
Multidrug resistance-associated protein 4	0	1	0	2
Bile salt export pump	0	2	0	2
ATP-binding cassette sub-family C member 3	0	1	0	2
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Bile salt export pump	0	2	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Cellular tumor antigen p53	3	0	0	3
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Glutamate receptor 2	2	0	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	2	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
glp-1 receptor, partial	2	0	0	2
RAR-related orphan receptor gamma	2	0	0	2
GALC protein	1	0	0	1
GLI family zinc finger 3	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
glucocorticoid receptor [Homo sapiens]	2	0	0	2
thyroid stimulating hormone receptor	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Chain A, Beta-lactamase	1	0	0	1
pregnane X receptor	1	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
nonstructural protein 1	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	1	0	0	1
pregnane X nuclear receptor	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
aryl hydrocarbon receptor	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	1	0	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Cytochrome P450 3A4	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
heat shock protein 90, putative	0	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Fibroma, Ossifying

Synonyms(1)

Research Excerpts

Overview

Research

Studies (57)

Drugs Studied (28)

Protein Targets (286)