Page last updated: 2024-11-05

tributylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Tributylamine is a colorless liquid with a pungent amine odor. It is a tertiary amine, meaning that the nitrogen atom is bonded to three alkyl groups (butyl groups in this case). Tributylamine is synthesized through the reaction of butylamine with an alkylating agent, such as butyl bromide. It is a versatile reagent used in various applications, including as a catalyst in organic synthesis, a solvent in the production of polymers and resins, and a corrosion inhibitor in metalworking fluids. It can also be used as a component in the preparation of pharmaceuticals, pesticides, and dyes. Tributylamine is studied due to its importance in various industrial processes, its potential toxicity, and its environmental impact. It is also the subject of research into its use in new and emerging technologies, such as renewable energy and green chemistry.'

tributylamine: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID7622
CHEMBL ID1877658
CHEBI ID38905
SCHEMBL ID896
MeSH IDM0110819

Synonyms (71)

Synonym
EN300-19754
tributyl-amine
ccris 4879
amine, tributyl-
ai3-15424
tributilamina [romanian]
hsdb 877
einecs 203-058-7
tris-n-butylamine
un2542
brn 1698872
tributylamine
n,n-dibutylbutan-1-amine
1-butanamine, n,n-dibutyl-
inchi=1/c12h27n/c1-4-7-10-13(11-8-5-2)12-9-6-3/h4-12h2,1-3h
tri-n-butylamine
CHEBI:38905 ,
tris[n-butylamine]
102-82-9
n,n-dibutyl-1-butanamine
NCGC00164374-01
tributylamine, puriss. plus, >=99.5% (gc)
tributylamine, puriss. p.a., >=99.0% (gc)
FT-0652663
T0357
NCGC00164374-02
NCGC00164374-03
AKOS005721142
dtxcid406183
NCGC00257977-01
NCGC00254008-01
tox21_300020
tox21_200423
dtxsid4026183 ,
cas-102-82-9
BBL011498
STL146610
c3tzb2w0r7 ,
ec 203-058-7
tributilamina
unii-c3tzb2w0r7
tributylamine [un2542] [poison]
tributylamine [hsdb]
tributylamine [mi]
BP-30098
SCHEMBL896
trin-butylamine
n(n-bu)3
tri-butyl amine
tri-n-butyl amine
nbu3
n,n-dibutylbutanamine
tri-n-butyl-amine
n-bu3n
tri n-butylamin
bu3n
tributylamin
tri(n-butyl)amine
tributyl amine
(n-c4h9)3n
un 2542
n,n-dibutyl-1-butanamine #
CHEMBL1877658
F0001-0072
mfcd00009431
J-525054
J-000810
tributylamine, >=98.5%
VS-02963
Q905558
tris(1-butyl)amine
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
tertiary amineA compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLI family zinc finger 3Homo sapiens (human)Potency24.28700.000714.592883.7951AID1259369
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency34.30630.003041.611522,387.1992AID1159552
retinoid X nuclear receptor alphaHomo sapiens (human)Potency27.67090.000817.505159.3239AID1159527; AID1159531
farnesoid X nuclear receptorHomo sapiens (human)Potency0.00100.375827.485161.6524AID588527
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency0.00110.001019.414170.9645AID588537
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency0.00250.023723.228263.5986AID588543
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (12.50)18.7374
1990's4 (16.67)18.2507
2000's7 (29.17)29.6817
2010's7 (29.17)24.3611
2020's3 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 47.92

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index47.92 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index4.75 (4.65)
Search Engine Demand Index71.11 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (47.92)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]