Page last updated: 2024-10-24

galactoside binding

Definition

Target type: molecularfunction

Binding to a glycoside in which the sugar group is galactose. [GOC:jl, ISBN:0198506732]

Galactoside binding is a molecular function that describes the ability of a protein or other molecule to interact with galactosides, which are sugar molecules containing galactose. Galactosides are found in various biological contexts, including glycoproteins, glycolipids, and polysaccharides. The binding of galactosides to proteins is often mediated by specific amino acid residues that form hydrogen bonds or other non-covalent interactions with the sugar molecule. This binding can lead to a variety of biological outcomes, including:

- **Cell signaling:** Galactoside binding can trigger signaling pathways within cells, leading to changes in gene expression or cell behavior. For example, the binding of lactose to the Lac repressor protein in bacteria regulates the expression of genes involved in lactose metabolism.
- **Enzyme activity:** Some enzymes require the binding of galactosides to function. For example, beta-galactosidase, an enzyme involved in the breakdown of lactose, requires the binding of lactose to its active site.
- **Adhesion:** Galactoside binding can mediate cell adhesion, allowing cells to interact with each other or with the extracellular matrix. For example, galectins, a family of proteins that bind galactosides, play roles in cell-cell adhesion, immune responses, and tumor growth.
- **Recognition:** Galactoside binding can be used by cells to recognize and interact with specific molecules. For example, the immune system uses galactoside-binding proteins to recognize foreign antigens.

The specificity of galactoside binding is determined by the structure of the binding site and the type of galactoside being recognized. Some proteins bind to specific galactoside structures, while others bind to a wider range of galactosides. The binding of galactosides can be affected by factors such as pH, temperature, and the presence of other molecules.

Overall, galactoside binding is a fundamental molecular function that is involved in a wide variety of biological processes. The study of galactoside binding provides insights into the mechanisms of cell signaling, enzyme activity, adhesion, and recognition.'
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Proteins (5)

ProteinDefinitionTaxonomy
Galectin-9A galectin-9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O00182]Homo sapiens (human)
Galectin-2A galectin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05162]Homo sapiens (human)
Galectin-4A galectin-4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P56470]Homo sapiens (human)
Beta-galactosidaseA eukaryotic-type beta-galactosidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16278]Homo sapiens (human)
Alpha-galactosidase AAn alpha-galactosidase A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06280]Homo sapiens (human)

Compounds (13)

CompoundDefinitionClassesRoles
galactosegalactopyranose : The pyranose form of galactose.D-galactose;
galactopyranose
Escherichia coli metabolite;
mouse metabolite
lactosebeta-lactose : The beta-anomer of lactose.

lactose : A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.

Lactose: A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.
lactose
congo redCongo Red : An indicator dye that is blue-violet at pH 3.0 and red at pH 5.0.

Congo Red: An acid dye used in testing for hydrochloric acid in gastric contents. It is also used histologically to test for AMYLOIDOSIS.
bis(azo) compound
1-deoxynojirimycin1-deoxy-nojirimycin: structure in first source

duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.
2-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid
anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite
iodophthalein
methyl alpha-d-galactopyranosidemethyl alpha-D-galactoside : An alpha-D-galactoside having a methyl substituent at the anomeric position.

methyl-galactopyranoside: structure in first source
alpha-D-galactoside;
methyl D-galactoside;
monosaccharide derivative
methyl beta-galactosidemethyl beta-D-galactoside : A beta-D-galactopyranoside having a methyl substituent at the anomeric position.

methyl beta-galactoside: RN given refers to (beta-D)-isomer

methyl galactoside : A methyl glycoside in which the H of the OH group on C-1 of galactose is replaced by a methyl group.
beta-D-galactoside;
methyl D-galactoside;
monosaccharide derivative
thiodigalactosidethiodigalactoside: RN given refers to beta-D-galactopyranoside (D-Gal)-isomer
methyl lactosidebeta-D-Gal-(1->4)-beta-D-Glc-OMe : A methyl glycoside comprising methyl beta-D-glucoside having an beta-D-galactosyl residue at the 4-position.disaccharide derivative;
methyl glycoside
migalastatmigalastat: a potent inhibitor of glycolipid biosynthesispiperidines
n-acetyllactosamineN-acetyllactosamine : A beta-D-galactopyranosyl-(1->4)-N-acetyl-D-glucosamine having beta-configuration at the reducing end anomeric centre.

N-acetyllactosamine: RN given refers to D-isomer
beta-D-Galp-(1->4)-D-GlcpNAc
isofagominepiperidines
galactalgalactal: RN given refers to cpd with unspecified isomeric designation; structureanhydrohexose;
glycal