| Assay ID | Title | Year | Journal | Article |
|---|
| AID1132122 | Toxicity in mouse allografted with mouse P388 cells assessed as change in body weight at 50 mg/kg administered daily as single dose | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID1132115 | Antileukemic activity against mouse P388 cells allografted in mouse at 25 mg/kg administered daily as single dose relative to control | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID403385 | Cytotoxicity against human DU145 cells after 48 hrs by SRB assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Antineoplastic agents. 553. The Texas grasshopper Brachystola magna. |
| AID1366150 | Antibacterial activity against Flavobacterium columnare BioMed | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Antibacterial constituents of the plant family Amaryllidaceae. |
| AID438119 | Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
| Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight. |
| AID1366151 | Antibacterial activity against Pseudomonas aeruginosa | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Antibacterial constituents of the plant family Amaryllidaceae. |
| AID1578097 | Antitrypanosomal activity against Leishmania donovani | 2019 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 29, Issue:20
| Antiprotozoal alkaloid principles of the plant family Amaryllidaceae. |
| AID632907 | Inhibition of human topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID491982 | Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay | 2010 | Journal of natural products, Jul-23, Volume: 73, Issue:7
| Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells. |
| AID438124 | Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
| Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight. |
| AID491983 | Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay | 2010 | Journal of natural products, Jul-23, Volume: 73, Issue:7
| Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells. |
| AID632906 | Inhibition of human topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 DNA | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID1366148 | Antibacterial activity against Escherichia coli | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Antibacterial constituents of the plant family Amaryllidaceae. |
| AID1132125 | Toxicity in mouse allografted with mouse P388 cells assessed as change in body weight at 3.13 mg/kg administered daily as single dose | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID491978 | Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay | 2010 | Journal of natural products, Jul-23, Volume: 73, Issue:7
| Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells. |
| AID632908 | Inhibition of Escherichia coli DNA topoisomerase 4-mediated relaxation of supercoiled pBR322 DNA | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID632916 | Antibacterial activity against Staphylococcus epidermidis by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID403382 | Cytotoxicity against human SF268 cells after 48 hrs by SRB assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Antineoplastic agents. 553. The Texas grasshopper Brachystola magna. |
| AID438126 | Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
| Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight. |
| AID311339 | Inhibition of AChE by Ellman method | 2007 | Journal of natural products, Sep, Volume: 70, Issue:9
| Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase. |
| AID632909 | Inhibition of Escherichia coli DNA topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID1366147 | Antibacterial activity against Flavobacterium columnare BioMed after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Antibacterial constituents of the plant family Amaryllidaceae. |
| AID491981 | Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay | 2010 | Journal of natural products, Jul-23, Volume: 73, Issue:7
| Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells. |
| AID1366145 | Antibacterial activity against Edwardsiella ictaluri after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Antibacterial constituents of the plant family Amaryllidaceae. |
| AID1132111 | Antileukemic activity against mouse P388 cells allografted in mouse assessed as host survival at 6.25 mg/kg administered daily as single dose | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID1132116 | Antileukemic activity against mouse P388 cells allografted in mouse at 12.5 mg/kg administered daily as single dose relative to control | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID438127 | Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
| Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight. |
| AID632910 | Binding affinity to calf thymus DNA assessed as change in absorption spectra at increasing concentration at pH 8 by UV-Vis spectra analysis | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID1366152 | Antibacterial activity against Staphylococcus aureus | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Antibacterial constituents of the plant family Amaryllidaceae. |
| AID632914 | Cytotoxicity against human HL60 cells after 72 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID633057 | Antibacterial activity against Salmonella typhi by agar dilution method | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID1132109 | Antileukemic activity against mouse P388 cells allografted in mouse assessed as host survival at 25 mg/kg administered daily as single dose | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID1366149 | Antibacterial activity against Flavobacterium columnare ALM-00-173 | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Antibacterial constituents of the plant family Amaryllidaceae. |
| AID1132108 | Antileukemic activity against mouse P388 cells allografted in mouse assessed as host survival at 50 mg/kg administered daily as single dose | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID403379 | Cytotoxicity against mouse P388 cells | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Antineoplastic agents. 553. The Texas grasshopper Brachystola magna. |
| AID1132110 | Antileukemic activity against mouse P388 cells allografted in mouse assessed as host survival at 12.5 mg/kg administered daily as single dose | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID632911 | Inhibition of human topoisomerase 2alpha kinetoplast DNA decatenation activity assessed as formation of monomeric circle from DNA at pH 8 after 1 hr | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID632915 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID491980 | Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay | 2010 | Journal of natural products, Jul-23, Volume: 73, Issue:7
| Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells. |
| AID1132114 | Antileukemic activity against mouse P388 cells allografted in mouse at 50 mg/kg administered daily as single dose relative to control | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID1366144 | Antibacterial activity against Corynebacterium fascians assessed as diameter of inhibition zone at 10 mM after 48 to 72 hrs by paper disc method | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Antibacterial constituents of the plant family Amaryllidaceae. |
| AID403383 | Cytotoxicity against human NCI-H460 cells after 48 hrs by SRB assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Antineoplastic agents. 553. The Texas grasshopper Brachystola magna. |
| AID1132123 | Toxicity in mouse allografted with mouse P388 cells assessed as change in body weight at 12.5 mg/kg administered daily as single dose | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID1132121 | Toxicity in mouse allografted with mouse P388 cells assessed as change in body weight at 25 mg/kg administered daily as single dose | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID403380 | Cytotoxicity against human BxPC3 cells after 48 hrs by SRB assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Antineoplastic agents. 553. The Texas grasshopper Brachystola magna. |
| AID403381 | Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Antineoplastic agents. 553. The Texas grasshopper Brachystola magna. |
| AID491979 | Cytotoxicity against human OE21 cells after 72 hrs by MTT colorimetric assay | 2010 | Journal of natural products, Jul-23, Volume: 73, Issue:7
| Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells. |
| AID1132117 | Antileukemic activity against mouse P388 cells allografted in mouse at 6.25 mg/kg administered daily as single dose relative to control | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID632913 | Stabilization of Escherichia coli DNA topoisomerase 1-DNA cleavage complex assessed as cleavage enhancement using 32P-TAACCCTGAAAGATTATGCAATGCGCTTTGGG ssDNA as substrate at 10 to 200 uM at pH 8 after 20 mins by agarose gel electrophoresis relative to cont | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID632912 | Inhibition of Escherichia coli topoisomerase 4 kinetoplast DNA decatenation activity assessed as formation of monomeric circle from DNA at pH 8 after 1 hr | 2011 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 21, Issue:23
| Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases. |
| AID1578093 | Antitrypanosomal activity against Trypanosoma cruzi | 2019 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 29, Issue:20
| Antiprotozoal alkaloid principles of the plant family Amaryllidaceae. |
| AID403384 | Cytotoxicity against human KM20L2 cells after 48 hrs by SRB assay | 2005 | Journal of natural products, Aug, Volume: 68, Issue:8
| Antineoplastic agents. 553. The Texas grasshopper Brachystola magna. |
| AID1578098 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense | 2019 | Bioorganic & medicinal chemistry letters, 10-15, Volume: 29, Issue:20
| Antiprotozoal alkaloid principles of the plant family Amaryllidaceae. |
| AID438125 | Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
| Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight. |
| AID1366146 | Antibacterial activity against Flavobacterium columnare ALM-00-173 after 24 hrs | 2017 | Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
| Antibacterial constituents of the plant family Amaryllidaceae. |
| AID438120 | Growth inhibition of proapoptotic stimuli-resistant human OE21 cells after 72 hrs by MTT assay | 2009 | Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
| Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight. |
| AID1132112 | Antileukemic activity against mouse P388 cells allografted in mouse assessed as host survival at 3.13 mg/kg administered daily as single dose | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID1132124 | Toxicity in mouse allografted with mouse P388 cells assessed as change in body weight at 6.25 mg/kg administered daily as single dose | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID1132118 | Antileukemic activity against mouse P388 cells allografted in mouse at 3.13 mg/kg administered daily as single dose relative to control | 1978 | Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
| Antileukemic activity of ungeremine and related compounds. Preparation of analogues of ungeremine by a practical photochemical reaction. |
| AID725736 | Inhibition of topoisomerase 2alpha in human A431 cells assessed as DNA peak fractions level after 1 hr by ICE assay | 2013 | Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
| Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs. |
| AID725728 | Inhibition of human recombinant topoisomerase 2alpha-mediated decatenation of kDNA at 50 uM after 60 mins by ethidium bromide staining based gel electrophoresis analysis | 2013 | Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
| Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs. |
| AID725735 | Inhibition of topoisomerase 2beta in human A431 cells assessed as DNA peak fractions level after 1 hr by ICE assay | 2013 | Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
| Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs. |
| AID725734 | Stabilization of topoisomerase 1/DNA complex in human A431 cells | 2013 | Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
| Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs. |
| AID725733 | Growth inhibition of human GXF251L cells after 72 hrs by SRB assay | 2013 | Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
| Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs. |
| AID725730 | Inhibition of human recombinant topoisomerase 1-mediated relaxation of supercoiled pUC18 plasmid DNA in human MCF7 cells nuclear extracts at 10 uM after 30 mins by ethidium bromide staining based gel electrophoresis analysis | 2013 | Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
| Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs. |
| AID725723 | Inhibition of human recombinant topoisomerase 2beta-mediated decatenation of kDNA at 30 uM after 60 mins by ethidium bromide staining based gel electrophoresis analysis | 2013 | Bioorganic & medicinal chemistry, Feb-01, Volume: 21, Issue:3
| Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |