Compounds > amarbellisine
Page last updated: 2024-11-12

amarbellisine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

amarbellisine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10017737
CHEMBL ID575533
MeSH IDM0584226

Synonyms (3)

Synonym
amarbellisine
CHEMBL575533
(1s,15s,18s,19s)-17-methoxy-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,16-tetraen-18-ol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID438126Growth inhibition of proapoptotic stimuli-resistant human SK-MEL-28 cells after 72 hrs by MTT assay2009Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
AID438128Growth inhibition of human WI38 cells after 72 hrs by MTT assay2009Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
AID438125Growth inhibition of proapoptotic stimuli-resistant human U373 cells after 72 hrs by MTT assay2009Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
AID491979Cytotoxicity against human OE21 cells after 72 hrs by MTT colorimetric assay2010Journal of natural products, Jul-23, Volume: 73, Issue:7
Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells.
AID491981Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay2010Journal of natural products, Jul-23, Volume: 73, Issue:7
Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells.
AID1366156Antibacterial activity against Staphylococcus aureus assessed as diameter of inhibition zone at 3 mg/ml2017Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
Antibacterial constituents of the plant family Amaryllidaceae.
AID491980Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay2010Journal of natural products, Jul-23, Volume: 73, Issue:7
Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells.
AID438127Growth inhibition of proapoptotic stimuli-sensitive mouse B16F10 cells after 72 hrs by MTT assay2009Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
AID491982Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay2010Journal of natural products, Jul-23, Volume: 73, Issue:7
Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells.
AID438124Growth inhibition of proapoptotic stimuli-sensitive human Hs683 cells after 72 hrs by MTT assay2009Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
AID438120Growth inhibition of proapoptotic stimuli-resistant human OE21 cells after 72 hrs by MTT assay2009Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
AID438119Growth inhibition of proapoptotic stimuli-resistant human A549 cells after 72 hrs by MTT assay2009Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
AID438129Growth inhibition of human WS1 cells after 72 hrs by MTT assay2009Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
AID491983Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay2010Journal of natural products, Jul-23, Volume: 73, Issue:7
Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells.
AID438130Growth inhibition of human NHDF after 72 hrs by MTT assay2009Journal of medicinal chemistry, Oct-22, Volume: 52, Issue:20
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
AID491978Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay2010Journal of natural products, Jul-23, Volume: 73, Issue:7
Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells.
AID1366154Antibacterial activity against Escherichia coli assessed as diameter of inhibition zone at 3 mg/ml2017Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
Antibacterial constituents of the plant family Amaryllidaceae.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.		3.2510penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
galantamine
Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.		3.2510benzazepine alkaloid fundamental parent;
benzazepine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound		antidote to curare poisoning;
cholinergic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.0810metal allergen;
nickel group element atom;
platinum group metal atom
narciclasine
narciclasine: antitumor alkaloid from bulbs of Narcissus species		3.2510phenanthridinesmetabolite
lycorine
lycorine: from bulbs of LYCORIS & other plants; RN given refers to (1 alpha,2 beta)-isomer; structure in Merck Index, 9th ed, #5444. lycorine : An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.		4.0940indolizidine alkaloidanticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor
lycoricidine
lycoricidine: antineoplastic from daffodil (Narcissus) bulbs; structure in first source		3.2510phenanthridines
hippadine
hippadine: isolated from Crinum bulbs		3.2510
trans-dihydronarciclasine
[no description available]		3.2510
lycorenine
lycorenine: from Lycoris radiata Herb. (Liliaceae); has vasodepressor effect; RN from 9th CI; RN given refers to (7alpha)-isomer		3.2510alkaloid
sitosterol, (3beta)-isomer
Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.		3.25103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C29-steroid;
phytosterols;
stigmastane sterol		anticholesteremic drug;
antioxidant;
mouse metabolite;
plant metabolite;
sterol methyltransferase inhibitor
anhydrolycorinone
anhydrolycorinone: structure in first source		3.2510phenanthridines
farrerol
farrerol: expectorant principle isolated from leaves of Rhododendron dauricum L; structure		3.2510organic molecular entitymetabolite
1-O-Acetyllycorine
1-acetyllycorine: has antiviral activity; structure in first source		3.5920alkaloid
pancracine
pancracine: structure in first source		3.2510isoquinoline alkaloid fundamental parent;
isoquinoline alkaloid
pseudolycorine
pseudolycorine: alkaloid isolated from Narcissus tazetta var. chinensis Roem, N. papyraceus or Lycoris radiata Herb; structure in first source		2.4620phenanthridines
sideroxylin
sideroxylin: from Hydrastis canadensis; structure in first source. sideroxylin : A monomethoxyflavone that is flavone substituted by a methoxy group at position 7, hydroxy groups at positions 5 and 4' and methyl groups at positions 6 and 8. It has been isolated from Hydrastis canadensis and Eucalyptus species.		3.2510dihydroxyflavone;
monomethoxyflavone		plant metabolite
ungeremine
[no description available]		3.8630organic molecular entitymetabolite
tazettine
tazettine: from Amaryllidaceae		2.0510indole alkaloid fundamental parent;
indole alkaloid
lyoniside
daucosterol : A steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa.		3.2510beta-D-glucoside;
monosaccharide derivative;
steroid saponin		plant metabolite
montanine
montanine: has anxiolytic, antidepressant, and anticonvulsant activities		3.2510
dihydrolycorine
[no description available]		2.0510
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		3.2510
ConditionIndicatedRelationship StrengthStudiesTrials
Malignant Melanoma
[description not available]		02.0510
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.0510