| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. | 2.21 | 1 | 0 | nucleobase analogue;
organofluorine compound | antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic |
cyclohexene
cyclohexene : A cycloalkene that is cylohexane with a single double bond. | 2.02 | 1 | 0 | cycloalkene | |
galantamine
Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils. | 2.47 | 2 | 0 | benzazepine alkaloid fundamental parent;
benzazepine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound | antidote to curare poisoning;
cholinergic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite |
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46. | 7.02 | 1 | 0 | metal allergen;
nickel group element atom;
platinum group metal atom | |
staurosporine
[no description available] | 2.07 | 1 | 0 | indolocarbazole alkaloid;
organic heterooctacyclic compound | apoptosis inducer;
bacterial metabolite;
EC 2.7.11.13 (protein kinase C) inhibitor;
geroprotector |
narciclasine
narciclasine: antitumor alkaloid from bulbs of Narcissus species | 2.07 | 1 | 0 | phenanthridines | metabolite |
lycorine
lycorine: from bulbs of LYCORIS & other plants; RN given refers to (1 alpha,2 beta)-isomer; structure in Merck Index, 9th ed, #5444. lycorine : An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity. | 2.98 | 4 | 0 | indolizidine alkaloid | anticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor |
pretazettine
pretazettine: potent inhibitor of viral reverse transcriptase; narcissus alkaloid; prolongs life of leukemic mice; RN given refers to (6a beta,8 beta)-isomer; structure | 7.02 | 1 | 0 | alkaloid | |
ungeremine
ungeremine: RN given refers to parent cpd; structure | 2.11 | 1 | 0 | | |
homolycorine
homolycorine: irritant isolated from daffodils (Narcissus pseudonarcissus L., Amaryllidaceae); structure given in first source | 2.47 | 2 | 0 | | |
crinine
crinine: structure in first source | 7.77 | 3 | 0 | alkaloid | |
carboplatin
[no description available] | 2.21 | 1 | 0 | | |
pancratistatin
pancratistatin: an isocarbostyril from Amaryllidaceae | 2.07 | 1 | 0 | citraconoyl group | |
1-O-Acetyllycorine
1-acetyllycorine: has antiviral activity; structure in first source | 2.05 | 1 | 0 | alkaloid | |
pseudolycorine
pseudolycorine: alkaloid isolated from Narcissus tazetta var. chinensis Roem, N. papyraceus or Lycoris radiata Herb; structure in first source | 2.05 | 1 | 0 | phenanthridines | |
hemanthidine
hemanthidine: crinine-like alkaloid from AMARYLLIDACEAE | 2.02 | 1 | 0 | | |
crinane
crinane: structure in first source | 2.05 | 1 | 0 | | |
tazettine
tazettine: from Amaryllidaceae | 2.05 | 1 | 0 | indole alkaloid fundamental parent;
indole alkaloid | |
montanine
montanine: has anxiolytic, antidepressant, and anticonvulsant activities | 2.05 | 1 | 0 | | |
fit-039
FIT-039: CDK9 inhibitor; structure in first source | 2.21 | 1 | 0 | | |
nifedipine
hemanthamine: crinine-like alkaloid from AMARYLLIDACEAE; RN given for (3beta,5alpha,11R,13beta,19alpha)-isomer; structure in first source | 2.05 | 1 | 0 | | |