Compounds > 7-deoxy-trans-dihydronarciclasine
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7-deoxy-trans-dihydronarciclasine

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Description

7-deoxy-trans-dihydronarciclasine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID454239
CHEMBL ID251056
SCHEMBL ID13271858
MeSH IDM0495531

Synonyms (5)

Synonym
7-deoxy-trans-dihydronarciclasine
(2s,3r,4s,4ar,11br)-2,3,4-trihydroxy-2,3,4,4a,5,11b-hexahydro-1h-[1,3]dioxolo[4,5-j]phenanthridin-6-one
[1,3]dioxolo[4,5-j]phenanthridin-6(2h)-one, 1,3,4,4a,5,11b-hexahydro-2,3,4-trihydroxy-, (2s,3r,4s,4ar,11br)-
CHEMBL251056
SCHEMBL13271858
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (113)

Assay IDTitleYearJournalArticle
AID335467Growth inhibition of human RPMI8226 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335739Growth inhibition of human M14 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335468Growth inhibition of human SR cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335474Growth inhibition of human NCI-H226 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335755Growth inhibition of human Caki1 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335465Growth inhibition of human K562 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335717Growth inhibition of human LXFL529 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335469Growth inhibition of human A549 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335720Growth inhibition of human COLO205 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID1283363Cytotoxicity against human ARPE19 cells assessed as cell viability at 0.1 to 50 uM after 24 to 48 hrs by live/dead fixable viability dye-based flow cytometric analysis2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID335472Growth inhibition of human HOP62 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335750Growth inhibition of human OVCAR8 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335727Growth inhibition of human KM20L2 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335752Growth inhibition of human 786-O cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID1283366Induction of sodium butyrate-induced reactivation of HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as decrease in EGFP MFI at 10 uM measured after 5 days of withdrawal relative to 5BVdU/IFN-alpha-treated cells2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID335742Growth inhibition of human SK-MEL-28 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID311339Inhibition of AChE by Ellman method2007Journal of natural products, Sep, Volume: 70, Issue:9
Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.
AID1283347Antiviral activity against HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as reduction in EGFP-positive cells at 10 uM treated at 2 hrs post infection measured 24 hrs post infection by flow cytometric analysis relative to control2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID335756Growth inhibition of human RXF393 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID1283354Antiviral activity against HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as reduction in expression of ICP4 gene at 10 uM measured 24 hrs post infection by RT-qPCR analysis2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID335743Growth inhibition of human SK-MEL-5 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID311338Antiviral activity against Tobacco mosaic virus U1 after 72 hrs by half leaf method2007Journal of natural products, Sep, Volume: 70, Issue:9
Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.
AID335732Growth inhibition of human SNB19 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID377105Cytotoxicity against human KM20L2 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID335738Growth inhibition of human MALME-3M cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335747Growth inhibition of human OVCAR-3 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335740Growth inhibition of human M19-MEL cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335748Growth inhibition of human OVCAR4 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335745Growth inhibition of human UACC62 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335730Growth inhibition of human SF295 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335758Growth inhibition of human TK10 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335759Growth inhibition of human UO31 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID378662Growth inhibition of human BXPC3 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID335715Growth inhibition of human NCI-H460 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335714Growth inhibition of human NCI-H322M cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335728Growth inhibition of human SW620 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335754Growth inhibition of human ACHN cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID377104Cytotoxicity against human NCI-H460 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID335737Growth inhibition of human LOXIMVI cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID377106Cytotoxicity against human DU145 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID1283360Antiviral activity against VZV infected in human ARPE19 cells at 10 uM treated at 2 hrs post infection measured 48 hrs post infection by luciferase assay relative to control2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID335729Growth inhibition of human SF268 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID1283343Antiviral activity against HSV1 KOS ATCC VR1493 infected in African green monkey Vero cells assessed as reduction in EGFP-positive cells at 10 uM treated at 2 hrs post infection measured 24 hrs post infection by flow cytometric analysis relative to contro2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID335723Growth inhibition of human HCT116 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335735Growth inhibition of human U251 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID1283372Antiviral activity against HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as reduction in expression of ICP4 at 10 uM measured 24 hrs post infection by western blot analysis2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID1283368Induction of sodium butyrate-induced reactivation of HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as reduction in EGFP/RFP-positive cells at 10 uM measured after 5 days of withdrawal by flow cytometric analysis relative to 5BVdU/IFN-gamma-tr2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID744400Selectivity index, ratio of CC50 for human Huh7.5 cells to EC50 for Hepatitis C virus2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Evaluation of anti-HCV activity and SAR study of (+)-lycoricidine through targeting of host heat-stress cognate 70 (Hsc70).
AID335473Growth inhibition of human HOP92 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID378661Growth inhibition of mouse P388 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID335751Growth inhibition of human SKOV3 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335741Growth inhibition of human SK-MEL-2 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID1283350Antiviral activity against HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as viral DNA replication at 10 uM measured 24 hrs post infection by FISH analysis2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID336621Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335722Growth inhibition of human HCC2998 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335470Growth inhibition of human EKVX cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335464Growth inhibition of human HL-60(TB) cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID377099Aqueous solubility at 25 degC2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID335734Growth inhibition of human SNB78 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335466Growth inhibition of human MOLT4 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID336617Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Dengue type 4 virus1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335744Growth inhibition of human UACC257 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335463Growth inhibition of human CCRF-CEM cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335733Growth inhibition of human SNB75 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID1283352Antiviral activity against HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as reduction in viral DNA copy at 10 uM measured 24 hrs post infection by RT-qPCR analysis relative to control2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID377100Cytotoxicity against mouse P388 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID335471Growth inhibition of human HOP18 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335736Growth inhibition of human XF498 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335757Growth inhibition of human SN12C cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335753Growth inhibition of human A498 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335716Growth inhibition of human NCI-H522 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID377101Cytotoxicity against human sBxPC-3 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID335718Growth inhibition of human DMS114 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335724Growth inhibition of human HCT15 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID377103Cytotoxicity against human SF-268 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID378667Growth inhibition of human DU145 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID1283364Induction of sodium butyrate-induced reactivation of HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as increase in EGFP-positive cells at 10 uM measured after 5 days of withdrawal by flow cytometric analysis relative to 5BVdU/IFN-alpha-treated2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID378663Growth inhibition of human MCF7 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID335731Growth inhibition of human SF539 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335475Growth inhibition of human NCI-H23 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335746Growth inhibition of human IGROV1 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID744401Antiviral activity against Hepatitis C virus infected in human Huh7.5 cells after 96 hrs by fluorescence microscopic analysis2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Evaluation of anti-HCV activity and SAR study of (+)-lycoricidine through targeting of host heat-stress cognate 70 (Hsc70).
AID1283365Induction of sodium butyrate-induced reactivation of HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as increase in EGFP-positive cells at 10 uM measured after 5 days of withdrawal in presence of IFN-alpha by flow cytometric analysis relative t2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID336623Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID1283349Antiviral activity against HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as reduction in virus yield at 10 uM treated at 2 hrs post infection measured 48 hrs post infection by flow cytometric analysis relative to control2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID336614Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335726Growth inhibition of human KM12 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID1283371Induction of sodium butyrate-induced reactivation of HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as decrease in EGFP/RFP MFI at 10 uM measured after 5 days of withdrawal in presence of IFN-alpha relative to 5BVdU/IFN-alpha-treated cells2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID1283361Antiviral activity against VZV infected in human ARPE19 cells treated at 2 hrs post infection measured 48 hrs post infection by luciferase assay2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID377102Cytotoxicity against human MCF7 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID378665Growth inhibition of human NCI-H460 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID336616Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335725Growth inhibition of human HT-29 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID1283359Cytotoxicity against human iPSC cells assessed as cell viability at 0.1 to 50 uM after 24 to 48 hrs by live/dead fixable viability dye-based flow cytometric analysis2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID335749Growth inhibition of human OVCAR5 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335721Growth inhibition of human DLD1 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID335719Growth inhibition of human DMS273 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID336615Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Yellow fever virus Ashibi1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID1283370Induction of sodium butyrate-induced reactivation of HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as decrease in EGFP/RFP MFI at 10 uM measured after 5 days of withdrawal relative to 5BVdU/IFN-alpha-treated cells2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID1283369Induction of sodium butyrate-induced reactivation of HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as reduction in EGFP/RFP-positive cells at 10 uM measured after 5 days of withdrawal in presence of IFN-alpha by flow cytometric analysis relat2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID1283367Induction of sodium butyrate-induced reactivation of HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as decrease in EGFP MFI at 10 uM measured after 5 days of withdrawal in presence of IFN-alpha relative to 5BVdU/IFN-alpha-treated cells2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID336612Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336624Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Rift valley fever virus1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID744412Cytotoxicity against human Huh7.5 cells treated after 96 hrs by MTT assay2013Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9
Evaluation of anti-HCV activity and SAR study of (+)-lycoricidine through targeting of host heat-stress cognate 70 (Hsc70).
AID1283345Antiviral activity against HSV1 KOS ATCC VR1493 infected in African green monkey Vero cells assessed as reduction in virus yield at 10 uM treated at 2 hrs post infection measured 48 hrs post infection by flow cytometric analysis relative to control2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID378666Growth inhibition of human KM20L2 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID335760Growth inhibition of mouse P388 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID1283358Antiviral activity against HSV1 KOS ATCC VR1493 infected in African green monkey Vero cells assessed as reduction in EGFP-positive cells treated at 2 hrs post infection measured 24 hrs post infection by flow cytometric analysis2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID1283356Antiviral activity against HSV1 KOS ATCC VR1493 infected in human iPSC cells assessed as reduction in expression of DNA polymerase gene at 10 uM measured 24 hrs post infection by RT-qPCR analysis2016ACS medicinal chemistry letters, Jan-14, Volume: 7, Issue:1
iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections.
AID336613Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Japanese encephalitis virus Nakayama1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID378664Growth inhibition of human SF269 cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine.
AID336625Antiviral activity against Sandfly fever sicilian virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336622Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Punta toro virus Adames1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (18.18)18.2507
2000's4 (36.36)29.6817
2010's4 (36.36)24.3611
2020's1 (9.09)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
tacrine
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.. tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease.		2.0310acridines;
aromatic amine		EC 3.1.1.7 (acetylcholinesterase) inhibitor
galantamine
Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.		2.0310benzazepine alkaloid fundamental parent;
benzazepine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound		antidote to curare poisoning;
cholinergic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.0510metal allergen;
nickel group element atom;
platinum group metal atom
ribavirin
Rebetron: Rebetron is tradename		2.03101-ribosyltriazole;
aromatic amide;
monocarboxylic acid amide;
primary carboxamide		anticoronaviral agent;
antiinfective agent;
antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
narciclasine
narciclasine: antitumor alkaloid from bulbs of Narcissus species		2.9440phenanthridinesmetabolite
lycorine
lycorine: from bulbs of LYCORIS & other plants; RN given refers to (1 alpha,2 beta)-isomer; structure in Merck Index, 9th ed, #5444. lycorine : An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.		2.420indolizidine alkaloidanticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor
lycoricidine
lycoricidine: antineoplastic from daffodil (Narcissus) bulbs; structure in first source		2.9340phenanthridines
trans-dihydronarciclasine
[no description available]		2.6830
dihydronarciclasine
dihydronarciclasine: isolated from Zephyranthes candida; structure given in first source; RN given refers to (2S-(2alpha,3beta,4beta,4abeta,11balpha))-isomer		7.0510
hemanthamine
[no description available]		2.0310alkaloid
pancratistatin
pancratistatin: an isocarbostyril from Amaryllidaceae		2.9240citraconoyl group
1-O-Acetyllycorine
1-acetyllycorine: has antiviral activity; structure in first source		2.0310alkaloid
pseudolycorine
pseudolycorine: alkaloid isolated from Narcissus tazetta var. chinensis Roem, N. papyraceus or Lycoris radiata Herb; structure in first source		1.9810phenanthridines
sanguinine
sanguinine: from Amaryllidaceae; structure in first source		2.0310benzazepine
7-deoxypancratistatin
7-deoxypancratistatin: a phytogenic antineoplastic agent; structure in first source		1.9810phenanthridines
antofine
antofine: structure in first source. (-)-antofine : An organic heteropentacyclic compound that is (13aR)-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline substituted at positions 2, 3 and 6 by methoxy groups. It is an alkaloid produced by relatives of the milkweed family and exhibits antiviral, anti-inflammatory, antiadipogenic and antitumorigenic activities.		2.0310alkaloid antibiotic;
alkaloid;
aromatic ether;
organic heteropentacyclic compound		angiogenesis inhibitor;
anti-inflammatory agent;
antimicrobial agent;
antineoplastic agent;
antiviral agent;
phytotoxin;
plant metabolite
ungeremine
[no description available]		2.0310organic molecular entitymetabolite
7-deoxynarciclasine
7-deoxynarciclasine: structure in first source		7.0310
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.13102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Japanese B
[description not available]		01.9810
Encephalitis, Japanese
A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)		01.9810
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		02.0310
Acute Confusional Senile Dementia
[description not available]		02.5920
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.5920
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.5920
Age-Related Memory Disorders
[description not available]		02.1710
Memory Disorders
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.		02.1710