homolycorine: irritant isolated from daffodils (Narcissus pseudonarcissus L., Amaryllidaceae); structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 160473 |
| CHEMBL ID | 1221973 |
| SCHEMBL ID | 4373999 |
| MeSH ID | M0161044 |
| Synonym |
|---|
| 9,10-dimethoxy-1-methyllycorenan-7-one |
| CHEMBL1221973 |
| [2]benzopyrano[3,4-g]indol-7(1h)-one, 2,3,5,5a,11b,11c-hexahydro-9,10-dimethoxy-1-methyl-, (5ar,11bs,11cs)- |
| homolycorine |
| (5ar,11bs,11cs)-9,10-dimethoxy-1-methyl-2,3,5,5a,11b,11c-hexahydroisochromeno[3,4-g]indol-7-one |
| 477-20-3 |
| lycorenan-7-one, 9,10-dimethoxy-1-methyl- |
| t95j9auu63 , |
| unii-t95j9auu63 |
| SCHEMBL4373999 |
| (+)-homolycorine |
| Q18349931 |
| DTXSID80963902 |
| (1s,10r,17s)-4,5-dimethoxy-16-methyl-9-oxa-16-azatetracyclo[8.7.0.0{2,7}.0{13,17}]heptadeca-2,4,6,12-tetraen-8-one |
| narcipoetine |
| (2)benzopyrano(3,4-g)indol-7(1h)-one, 2,3,5,5a,11b,11c-hexahydro-9,10-dimethoxy-1-methyl-, (5ar-(5a.alpha.,11b.alpha.,11c.beta.))- |
| (5ar,11bs,11cs)-2,3,5,5a,11b,11c-hexahydro-9,10-dimethoxy-1-methyl(2)benzopyrano(3,4-g)indol-7(1h)-one |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID688349 | Cytotoxicity against human HeLa cells after 72 hrs by Calcein AM assay | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae. |
| AID501441 | Inhibition of AChE at 10 uM by Ellman's assay | 2010 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 20, Issue:17 | Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids. |
| AID688347 | Cytotoxicity against human K562 cells after 72 hrs by Calcein AM assay | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae. |
| AID688348 | Cytotoxicity against human MCF7 cells after 72 hrs by Calcein AM assay | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae. |
| AID688351 | Cytotoxicity against human BJ cells after 72 hrs by Calcein AM assay | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae. |
| AID688344 | Cytotoxicity against human CEM cells after 72 hrs by Calcein AM assay | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae. |
| AID688350 | Cytotoxicity against human G361 cells after 72 hrs by Calcein AM assay | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19 | Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.79) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||