Compounds > trans-dihydronarciclasine
Page last updated: 2024-12-07

trans-dihydronarciclasine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Cross-References

ID SourceID
PubMed CID101204
CHEMBL ID464432
SCHEMBL ID14732745
MeSH IDM0177239

Synonyms (9)

Synonym
nsc381837
40042-05-5
trans-dihydronarciclasine
[1,3]dioxolo[4,5-j]phenanthridin-6(2h)-one, 1,3,4,4a,5,11b-hexahydro-2,3,4,7-tetrahydroxy-, (2s,3r,4s,4ar,11br)-
(2s,3r,4s,4ar,11br)-2,3,4,7-tetrahydroxy-2,3,4,4a,5,11b-hexahydro-1h-[1,3]dioxolo[4,5-j]phenanthridin-6-one
CHEMBL464432
(1,3)dioxolo(4,5-j)phenanthridin-6(2h)-one, 1,3,4,4a,5,11b-hexahydro-2,3,4,7-tetrahydroxy-, (2s-(2alpha,3beta,4beta,4abeta, 11balpha))-
nsc 381837
SCHEMBL14732745
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID336623Antiviral activity against Rift Valley fever virus infected in african green monkey Vero cells after 6 days by plaque reduction assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336621Antiviral activity against Punta Toro virus Adames infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID335273Cytotoxicity against mouse P388 cells
AID377106Cytotoxicity against human DU145 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID336615Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Yellow fever virus Ashibi1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID568740Inhibition of human CYP1A1 at 10 uM2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Human cytochrome P450 liability studies of trans-dihydronarciclasine: a readily available, potent, and selective cancer cell growth inhibitor.
AID568741Inhibition of human CYP19 at 10 uM2011Journal of natural products, Jan-28, Volume: 74, Issue:1
Human cytochrome P450 liability studies of trans-dihydronarciclasine: a readily available, potent, and selective cancer cell growth inhibitor.
AID377100Cytotoxicity against mouse P388 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID1366140Antibacterial activity against Escherichia coli after 24 hrs by broth microdilution method2017Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
Antibacterial constituents of the plant family Amaryllidaceae.
AID377102Cytotoxicity against human MCF7 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID335760Growth inhibition of mouse P388 cells1993Journal of natural products, Oct, Volume: 56, Issue:10
Antineoplastic agents, 256. Cell growth inhibitory isocarbostyrils from Hymenocallis.
AID336617Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Dengue type 4 virus1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID1366141Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by broth microdilution method2017Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
Antibacterial constituents of the plant family Amaryllidaceae.
AID377099Aqueous solubility at 25 degC2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID336612Antiviral activity against Japanese encephalitis virus Nakayama infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID377104Cytotoxicity against human NCI-H460 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID377105Cytotoxicity against human KM20L2 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID377101Cytotoxicity against human sBxPC-3 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID336625Antiviral activity against Sandfly fever sicilian virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336622Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Punta toro virus Adames1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID377103Cytotoxicity against human SF-268 cells2005Journal of natural products, Feb, Volume: 68, Issue:2
Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1).
AID1366142Antibacterial activity against Shigella flexneri after 24 hrs by broth microdilution method2017Bioorganic & medicinal chemistry letters, 11-15, Volume: 27, Issue:22
Antibacterial constituents of the plant family Amaryllidaceae.
AID336613Therapeutic index, ratio of TC50 for african green monkey Vero cells to IC50 for Japanese encephalitis virus Nakayama1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336614Antiviral activity against Yellow fever virus Ashibi infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect by MTT assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
AID336616Antiviral activity against Dengue virus type 4 infected in african green monkey Vero cells after 6 days by plaque reduction assay1992Journal of natural products, Nov, Volume: 55, Issue:11
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (16.67%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
penicillin g
Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.. benzylpenicillin : A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.		3.2510penicillin allergen;
penicillin		antibacterial drug;
drug allergen;
epitope
galantamine
Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils.		3.2510benzazepine alkaloid fundamental parent;
benzazepine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound		antidote to curare poisoning;
cholinergic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite
narciclasine
narciclasine: antitumor alkaloid from bulbs of Narcissus species		8.8230phenanthridinesmetabolite
lycorine
lycorine: from bulbs of LYCORIS & other plants; RN given refers to (1 alpha,2 beta)-isomer; structure in Merck Index, 9th ed, #5444. lycorine : An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.		3.5220indolizidine alkaloidanticoronaviral agent;
antimalarial;
plant metabolite;
protein synthesis inhibitor
lycoricidine
lycoricidine: antineoplastic from daffodil (Narcissus) bulbs; structure in first source		3.8130phenanthridines
hippadine
hippadine: isolated from Crinum bulbs		3.2510
lycorenine
lycorenine: from Lycoris radiata Herb. (Liliaceae); has vasodepressor effect; RN from 9th CI; RN given refers to (7alpha)-isomer		3.2510alkaloid
sitosterol, (3beta)-isomer
Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.		3.25103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
C29-steroid;
phytosterols;
stigmastane sterol		anticholesteremic drug;
antioxidant;
mouse metabolite;
plant metabolite;
sterol methyltransferase inhibitor
anhydrolycorinone
anhydrolycorinone: structure in first source		3.2510phenanthridines
pancratistatin
pancratistatin: an isocarbostyril from Amaryllidaceae		2.3820citraconoyl group
farrerol
farrerol: expectorant principle isolated from leaves of Rhododendron dauricum L; structure		3.2510organic molecular entitymetabolite
1-O-Acetyllycorine
1-acetyllycorine: has antiviral activity; structure in first source		3.2510alkaloid
pancracine
pancracine: structure in first source		3.2510isoquinoline alkaloid fundamental parent;
isoquinoline alkaloid
pseudolycorine
pseudolycorine: alkaloid isolated from Narcissus tazetta var. chinensis Roem, N. papyraceus or Lycoris radiata Herb; structure in first source		1.9810phenanthridines
7-deoxypancratistatin
7-deoxypancratistatin: a phytogenic antineoplastic agent; structure in first source		1.9810phenanthridines
7-deoxy-trans-dihydronarciclasine
7-deoxy-trans-dihydronarciclasine: structure in first source		2.6830
sideroxylin
sideroxylin: from Hydrastis canadensis; structure in first source. sideroxylin : A monomethoxyflavone that is flavone substituted by a methoxy group at position 7, hydroxy groups at positions 5 and 4' and methyl groups at positions 6 and 8. It has been isolated from Hydrastis canadensis and Eucalyptus species.		3.2510dihydroxyflavone;
monomethoxyflavone		plant metabolite
ungeremine
[no description available]		3.2510organic molecular entitymetabolite
lyoniside
daucosterol : A steroid saponin that is sitosterol attached to a beta-D-glucopyranosyl residue at position 3 via a glycosidic linkage. It has bee isolated from Panax japonicus var. major and Breynia fruticosa.		3.2510beta-D-glucoside;
monosaccharide derivative;
steroid saponin		plant metabolite
amarbellisine
amarbellisine: structure in first source		3.2510
montanine
montanine: has anxiolytic, antidepressant, and anticonvulsant activities		3.2510
tetracycline
Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.. tetracycline : A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria.		3.2510
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalitis, Japanese B
[description not available]		01.9810
Encephalitis, Japanese
A mosquito-borne encephalitis caused by the Japanese B encephalitis virus (ENCEPHALITIS VIRUS, JAPANESE) occurring throughout Eastern Asia and Australia. The majority of infections occur in children and are subclinical or have features limited to transient fever and gastrointestinal symptoms. Inflammation of the brain, spinal cord, and meninges may occur and lead to transient or permanent neurologic deficits (including a POLIOMYELITIS-like presentation); SEIZURES; COMA; and death. (From Adams et al., Principles of Neurology, 6th ed, p751; Lancet 1998 Apr 11;351(9109):1094-7)		01.9810