cyclic diadenosine phosphate profile

cyclic di-AMP : A cyclic purine dinucleotide that is the 3',5'-cyclic dimer of AMP. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	11158091
CHEMBL ID	1229884
CHEBI ID	71578
SCHEMBL ID	18700333
MeSH ID	M0521566

Synonyms (37)

Synonym
chebi:71578 ,
CHEMBL1229884 ,
(2r,3r,3as,5r,7ar,9r,10r,10as,12r,14ar)-2,9-bis(6-amino-9h-purin-9-yl)octahydro-2h,7h-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide
2ba ,
(2r,3r,3as,5r,7ar,9r,10r,10as,12r,14ar)-2,9-bis(6-amino-9h-purin-9-yl)octahydro-2h,7h-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide
C20565
cyclic di-amp
cyclic di-3',5'-adenylic acid
3',5'-cyclic di-amp
(2r,3r,3as,7ar,9r,10r,10as,14ar)-2,9-bis(6-amino-9h-purin-9-yl)octahydro-2h,7h-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide
bis-(3'-5')-cyclic dimeric adenosine monophosphate
bis(3',5')-cyclic diadenylic acid
c-di-amp
HY-12326
CS-3325
54447-84-6
AKOS030526840
SCHEMBL18700333
cyclic diadenylate
3',5'-cyclic diadenylic acid
3'-adenylic acid, adenylyl-(3'->5')-, cyclic nucleotide
cyclic-di-amp
unii-wh9b66eix2
wh9b66eix2 ,
acetic acid, 4-(2,6-dihydro-2,6-dioxo-7-phenylbenzo1,2-b:4,5-bdifuran-3-yl)phenoxy-, 2-ethoxyethyl e
126877-05-2
bis-(3',5')-cyclic-dimeric-adenosine-monophosphate
(2r,3r,3as,5r,7ar,9r,10r,10as,12r,14ar)-2,9-bis(6-amino-9h-purin-9-yl)octahydro-2h,7h-difuro[3,2-d:3',2'-j][1,3,7,9,2,8
]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide
Q27139726
(1s,6r,8r,9r,10s,15r,17r,18r)-8,17-bis(6-aminopurin-9-yl)-3,12-dihydroxy-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3lambda5,12lambda5-diphosphatricyclo[13.3.0.06,10]octadecane-9,18-diol
EX-A3317
c-di-amp(cyclic-di-amp)
bdbm50509429
DTXSID201317771
(2r,3r,3as,7ar,9r,10r,10as,14ar)-2,9-bis(6-amino-9h-purin-9-yl)-3,5,10,12-tetrahydroxyoctahydro-2h,7h-difuro[3,2-d:3',2'-j][1,3,7,9]tetraoxa[2,8]diphosphacyclododecine 5,12-dioxide
(1s,6r,8r,9r,10s,15r,17r,18r)-8,17-bis(6-amino-9h-purin-9-yl)-3,9,12,18-tetrahydroxy-2,4,7,11,13,16-hexaoxa-3,12-diphosphatricyclo[13.3.0.0,octadecane-3,12-dione

Role	Description
Mycoplasma genitalium metabolite	Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
cyclic purine dinucleotide
adenyl ribonucleotide	A purine riboncleotide where adenine is the purine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Stimulator of interferon genes protein	Homo sapiens (human)	EC50 (µMol)	3.2873	0.0058	1.3611	7.2000	AID1541395; AID1541396; AID1541397; AID1541399; AID1541400; AID1814337; AID1861453
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
protein complex oligomerization	Stimulator of interferon genes protein	Homo sapiens (human)
autophagosome assembly	Stimulator of interferon genes protein	Homo sapiens (human)
activation of innate immune response	Stimulator of interferon genes protein	Homo sapiens (human)
pattern recognition receptor signaling pathway	Stimulator of interferon genes protein	Homo sapiens (human)
positive regulation of defense response to virus by host	Stimulator of interferon genes protein	Homo sapiens (human)
cytoplasmic pattern recognition receptor signaling pathway	Stimulator of interferon genes protein	Homo sapiens (human)
positive regulation of macroautophagy	Stimulator of interferon genes protein	Homo sapiens (human)
positive regulation of protein binding	Stimulator of interferon genes protein	Homo sapiens (human)
positive regulation of type I interferon production	Stimulator of interferon genes protein	Homo sapiens (human)
positive regulation of interferon-beta production	Stimulator of interferon genes protein	Homo sapiens (human)
cellular response to interferon-beta	Stimulator of interferon genes protein	Homo sapiens (human)
innate immune response	Stimulator of interferon genes protein	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Stimulator of interferon genes protein	Homo sapiens (human)
regulation of inflammatory response	Stimulator of interferon genes protein	Homo sapiens (human)
positive regulation of DNA-binding transcription factor activity	Stimulator of interferon genes protein	Homo sapiens (human)
protein complex oligomerization	Stimulator of interferon genes protein	Homo sapiens (human)
defense response to virus	Stimulator of interferon genes protein	Homo sapiens (human)
positive regulation of type I interferon-mediated signaling pathway	Stimulator of interferon genes protein	Homo sapiens (human)
reticulophagy	Stimulator of interferon genes protein	Homo sapiens (human)
protein localization to endoplasmic reticulum	Stimulator of interferon genes protein	Homo sapiens (human)
cellular response to exogenous dsRNA	Stimulator of interferon genes protein	Homo sapiens (human)
cellular response to organic cyclic compound	Stimulator of interferon genes protein	Homo sapiens (human)
antiviral innate immune response	Stimulator of interferon genes protein	Homo sapiens (human)
cGAS/STING signaling pathway	Stimulator of interferon genes protein	Homo sapiens (human)
proton transmembrane transport	Stimulator of interferon genes protein	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
protein binding	Stimulator of interferon genes protein	Homo sapiens (human)
proton channel activity	Stimulator of interferon genes protein	Homo sapiens (human)
protein kinase binding	Stimulator of interferon genes protein	Homo sapiens (human)
ubiquitin protein ligase binding	Stimulator of interferon genes protein	Homo sapiens (human)
cyclic-di-GMP binding	Stimulator of interferon genes protein	Homo sapiens (human)
signaling adaptor activity	Stimulator of interferon genes protein	Homo sapiens (human)
identical protein binding	Stimulator of interferon genes protein	Homo sapiens (human)
protein homodimerization activity	Stimulator of interferon genes protein	Homo sapiens (human)
2',3'-cyclic GMP-AMP binding	Stimulator of interferon genes protein	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Stimulator of interferon genes protein	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
Golgi membrane	Stimulator of interferon genes protein	Homo sapiens (human)
endoplasmic reticulum membrane	Stimulator of interferon genes protein	Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment membrane	Stimulator of interferon genes protein	Homo sapiens (human)
Golgi membrane	Stimulator of interferon genes protein	Homo sapiens (human)
autophagosome membrane	Stimulator of interferon genes protein	Homo sapiens (human)
nucleoplasm	Stimulator of interferon genes protein	Homo sapiens (human)
mitochondrial outer membrane	Stimulator of interferon genes protein	Homo sapiens (human)
endosome	Stimulator of interferon genes protein	Homo sapiens (human)
autophagosome	Stimulator of interferon genes protein	Homo sapiens (human)
peroxisome	Stimulator of interferon genes protein	Homo sapiens (human)
endoplasmic reticulum membrane	Stimulator of interferon genes protein	Homo sapiens (human)
cytosol	Stimulator of interferon genes protein	Homo sapiens (human)
plasma membrane	Stimulator of interferon genes protein	Homo sapiens (human)
cytoplasmic vesicle membrane	Stimulator of interferon genes protein	Homo sapiens (human)
secretory granule membrane	Stimulator of interferon genes protein	Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment membrane	Stimulator of interferon genes protein	Homo sapiens (human)
perinuclear region of cytoplasm	Stimulator of interferon genes protein	Homo sapiens (human)
serine/threonine protein kinase complex	Stimulator of interferon genes protein	Homo sapiens (human)
STING complex	Stimulator of interferon genes protein	Homo sapiens (human)
autophagosome	Stimulator of interferon genes protein	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (23)

Assay ID	Title	Year	Journal	Article
AID1541398	Activation of recombinant human STING haplotype R232H mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1541400	Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1541397	Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1541409	Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay relative to 2'3'cGAMP	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1861453	Agonist activity at STING (unknown origin)	2022	European journal of medicinal chemistry, Aug-05, Volume: 238	Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration.
AID1814340	Activation of human STING QA mutant expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation by luciferase reporter gene assay	2021	Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11	Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
AID1541399	Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1814338	Activation of human STING HAQ mutant expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation by luciferase reporter gene assay	2021	Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11	Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
AID1541405	Ratio of EC50 for recombinant human wild-type STING expressed in 293T cells in absence of digitonin A to EC50 for recombinant human wild-type STING expressed in 293T cells in presence of digitonin A	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1541407	Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay relative to 2'3'cGAMP	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1541408	Activation of recombinant human STING haplotype R232H mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay relative to 2'3'cGAMP	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1541395	Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase reporter gene assay	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1824688	Non-competitive inhibition of pyruvate carboxylase (unknown origin)	2022	Journal of medicinal chemistry, 01-13, Volume: 65, Issue:1	Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
AID1485942	Drug metabolism assessed as recombinant Bacillus subtilis YybT-mediated compound hydrolysis by measuring half life at 100 uM by reversed-phase HPLC method	2017	Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14	Synthesis and evaluation of c-di-4'-thioAMP as an artificial ligand for c-di-AMP riboswitch.
AID1814339	Activation of human STING REF mutant expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation by luciferase reporter gene assay	2021	Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11	Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
AID1575506	Binding affinity to anemone STING	2019	MedChemComm, Dec-01, Volume: 10, Issue:12	Interrupting cyclic dinucleotide-cGAS-STING axis with small molecules.
AID1814337	Activation of wild-type human STING expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation by luciferase reporter gene assay	2021	Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11	Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
AID1541406	Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay relative to 2'3'cGAMP	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1485938	Binding affinity to Bacillus substilis 5'-32p-labelled 165 nucleotide RNA assessed as reduction in RNA cleavage measured within 40 hrs by PAGE analysis	2017	Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14	Synthesis and evaluation of c-di-4'-thioAMP as an artificial ligand for c-di-AMP riboswitch.
AID1541410	Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay relative to 2'3'cGAMP	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1541394	Binding affinity to recombinant human wild-type STING assessed as change in melting temperature at 150 uM by SYPRO orange dye based differential scanning fluorimetric method	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1541396	Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase reporter gene assay	2019	Journal of medicinal chemistry, 12-12, Volume: 62, Issue:23	Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
AID1814341	Activation of human STING Q mutant expressed in digitonin treated HEK293T cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation by luciferase reporter gene assay	2021	Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11	Synthesis and Biological Evaluation of Phosphoester and Phosphorothioate Prodrugs of STING Agonist 3',3'-c-Di(2'F,2'dAMP).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (50.00)	24.3611
2020's	3 (50.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (16.67%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (83.33%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
oxaloacetic acid Oxaloacetic Acid: A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.. oxaloacetic acid : An oxodicarboxylic acid that is succinic acid bearing a single oxo group.	2.41	1	C4-dicarboxylic acid; oxo dicarboxylic acid	geroprotector; metabolite
aspartic acid Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.	2.41	1	aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; mouse metabolite; neurotransmitter
10-carboxymethyl-9-acridanone 10-carboxymethyl-9-acridanone: RN given refers to parent cpd	3.78	2	acridines
octyl gallate [no description available]	2.41	1	gallate ester	food antioxidant; hypoglycemic agent; plant metabolite
ribavirin 5'-triphosphate ribavirin 5'-triphosphate: structure given in first source. ribavirin 5'-triphosphate : A 1-ribosyltriazole that is ribavirin in which the hydroxy group at the 5'-position is replaced by a triphosphate group. It is the active metabolite of the antiviral agent ribavirin.	2.21	1	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide; ribose triphosphate	antiviral agent; drug metabolite; EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor; eukaryotic initiation factor 4F inhibitor; human blood serum metabolite
vadimezan vadimezan : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a 5,6-dimethyl-9-oxoxanthen-4-yl group.	3.78	2	monocarboxylic acid; xanthones	antineoplastic agent
5-aminoimidazole-4-carboxamide-1-ribofuranosyl triphosphate [no description available]	2.21	1
8-hydroxyadenosine 5'-triphosphate [no description available]	2.21	1	purine ribonucleoside 5'-triphosphate
2-chloro-atp 2-chloro-ATP: new ATP analog; relaxes mammalian gut preparations; structure	2.21	1
dendrophenol dendrophenol: isolated from Dendrobium loddigesii	2.41	1
erianin Erianin: from Dendrobium chrysotoxum; structure in first source	2.41	1
xanthosine 5'-triphosphate xanthosine 5'-triphosphate: RN given refers to parent cpd	2.21	1	purine ribonucleoside 5'-triphosphate; xanthosine 5'-phosphate	Escherichia coli metabolite; mouse metabolite
Hircinol [no description available]	2.41	1	phenanthrenes
rhapontin rhapontin: constituent of rhubarb rhizome	2.41	1	rhaponticin	angiogenesis inhibitor; anti-allergic agent; anti-inflammatory agent; antilipemic drug; antineoplastic agent; apoptosis inducer; EC 2.3.1.85 (fatty acid synthase) inhibitor; hypoglycemic agent; neuroprotective agent; plant metabolite
8-azidoadenosine 5'-triphosphate [no description available]	2.21	1
6-thioinosine-5'-triphosphate [no description available]	2.21	1	organic molecule
gigantol gigantol: structure in first source	2.41	1
mangostin mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.	3.31	1	aromatic ether; phenols; xanthones	antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite
vx680 [no description available]	3.31	1	N-arylpiperazine
bx795 BX795: structure in first source	3.31	1	ureas
6-thioguanosine 5'-triphosphate [no description available]	2.21	1
2-fluoro-araatp [no description available]	2.21	1
mrt67307 MRT67307: IKK (IκB(inhibitor of NF-κB (nuclear factor κB)) kinase) family inhibitor; structure in first source	3.31	1	aromatic amine
inosine triphosphate Inosine Triphosphate: Inosine 5'-(tetrahydrogen triphosphate). An inosine nucleotide containing three phosphate groups esterified to the sugar moiety. Synonym: IRPPP.	2.21	1	inosine phosphate; purine ribonucleoside 5'-triphosphate	Escherichia coli metabolite; human metabolite; mouse metabolite
bis(3',5')-cyclic diguanylic acid [no description available]	4.28	4	cyclic purine dinucleotide; guanyl ribonucleotide	immunomodulator; signalling molecule
cyclic guanosine monophosphate-adenosine monophosphate c-GMP-AMP : A cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages.	4.28	4	adenyl ribonucleotide; cyclic purine dinucleotide; guanyl ribonucleotide
8-hydroxyguanosine triphosphate [no description available]	2.21	1
guanosine 5'-o-(1-thiotriphosphate) [no description available]	2.21	1
cyclic guanosine monophosphate-adenosine monophosphate 2'-3'-cGAMP : A cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'- and 2',5'-linkages respectively.	4.04	3	adenyl ribonucleotide; cyclic purine dinucleotide; guanyl ribonucleotide

Condition	Relationship Strength	Studies
Hepatocellular Carcinoma [description not available]	2.41	1
Cancer of Liver [description not available]	2.41	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.41	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.41	1
Benign Neoplasms [description not available]	2.41	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.41	1

cyclic diadenosine phosphate

Description

Cross-References

Synonyms (37)

Roles (1)

Drug Classes (2)

Protein Targets (1)

Activation Measurements

Biological Processes (24)

Molecular Functions (10)

Ceullar Components (16)

Bioassays (23)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.85

Study Types

cyclic diadenosine phosphate

Description

Cross-References

Synonyms (37)

Roles (1)

Drug Classes (2)

Protein Targets (1)

Activation Measurements

Biological Processes (24)

Molecular Functions (10)

Ceullar Components (16)

Bioassays (23)

Research

Studies (6)

Market Indicators

Research Demand Index: 12.85

Study Types

Related Drugs (29)

Related Conditions (6)