Compounds > michellamine c
Page last updated: 2024-12-08

michellamine c

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Description

michellamine A: atropisomeric naphthylisoquinoline anti-HIV cytopathic alkaloid dimers; from tropical plant Ancistrocladus abbreviatus; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

michellamine A : A dimeric isoquinoline alkaloid isolated from Ancistrocladus abbreviatus and has been shown to exhibit anti-HIV activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID454909
CHEMBL ID295292
SCHEMBL ID2041331
MeSH IDM0195770

Synonyms (15)

Synonym
143168-23-4
(1r,3r)-5-[3-[4-[(1r,3r)-6,8-dihydroxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-5-yl]-1-hydroxy-8-methoxy-6-methyl-2-naphthyl]-4-hydroxy-5-methoxy-7-methyl-1-naphthyl]-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol
5,5-(1,1'-dihydroxy-8-8'-dimethoxy-6,6'-dimethyl[2,2'-binaphthalene-4,4'-diyl)bis[1,2,3,4-tetrahydro-1,3-dimethyl-6,8-isoquinolinediol], (1r,3r,5r,1'r,3'r,5'r)
michellamine c
NSC649324 ,
michellamine a
NSC650898 ,
(1r,3r)-5-[3-[4-[(1r,3r)-6,8-dihydroxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-5-yl]-1-hydroxy-8-methoxy-6-methylnaphthalen-2-yl]-4-hydroxy-5-methoxy-7-methylnaphthalen-1-yl]-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-6,8-diol
CHEMBL295292
5,5-(1,1'-dihydroxy-8-8'-dimethoxy-6,6'-dimethyl(2,2'-binaphthalene-4,4'-diyl)bis(1,2,3,4-tetrahydro-1,3-dimethyl-6,8-isoquinolinediol), (1r,3r,5r,1'r,3'r,5'r)
michellamine
SCHEMBL2041331
DTXSID50162329
bdbm50058296
Q6836897
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (60)

Assay IDTitleYearJournalArticle
AID156043Cytotoxicity was measured against PMCs/HIV-1(Ba-L)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID9465Anti -HIV activity was measured against AA5/HIV-1(IIIB)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID44604Anti -HIV activity was measured against C-344/HIV-1(RF)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45358Anti-HIV activity was measured against HIV-1 Lymphotropic MCK clinical isolates in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID46005Anti -HIV activity was measured against 174*CEM/HIV-1(IIIB)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45354Anti -HIV activity was measured against CEM-SS/HIV-1 (NIH-DZ)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45372Anticytopathic activity was measured against HIV-2(CBL-20 strain) in CEM-SS human lymphoblastoid target cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID403974Antiviral activity against HIV1 G9106 infected in human MT2 cells1997Journal of natural products, Jul, Volume: 60, Issue:7
Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
AID1187987Antimicrobial activity against Escherichia coli DH5[alpha] at 1.95 to 125 ug/ml by liquid culture microtitre plate assay2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID45371Anticytopathic activity was measured against HIV-1(RF strain) in CEM-SS human lymphoblastoid target cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID397756Therapeutic index, ratio of cytotoxicity against human CEM-SS cells to EC50 for HIV12001Journal of natural products, Feb, Volume: 64, Issue:2
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
AID45364Anti-HIV activity was measured against HIV-1,IIIB laboratory strains in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID106894Anti-HIV activity was measured against drug resistant HIV-1 A17 in MT-2 cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID46450Cytotoxicity was measured against CEM-SS/HIV-1 (RF)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID106926Cytotoxicity was measured against MT-2/HIV-1(RF).1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID1187983Inhibition of MraY in Staphylococcus aureus membranes at 500 uM by continuous fluorescence assay2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID44665Anti -HIV activity was measured against C8166/HIV-1(RF)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45367Anti-HIV activity was measured against HIV-2 CBL-20 laboratory strains in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45363Anti-HIV activity was measured against HIV-1 Promonocytropic TPI clinical isolates in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45361Anti-HIV activity was measured against HIV-1 Promonocytropic MN clinical isolates in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID106888Anti -HIV activity was measured against MT-2/HIV-1(RF)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID100083Cytotoxicity was measured against LDV-7/HIV-1(RF)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45362Anti-HIV activity was measured against HIV-1 Promonocytropic SKI clinical isolates in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID106895Anti-HIV activity was measured against drug resistant HIV-1 G9106 in MT-2 cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID403973Antiviral activity against HIV1 A17 infected in human MT2 cells1997Journal of natural products, Jul, Volume: 60, Issue:7
Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
AID44805Cytotoxicity was measured against C8166/HIV-1(RF)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID1187984Inhibition of MraY in Micrococcus flavus membranes at 500 uM by continuous fluorescence assay2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID45359Anti-HIV activity was measured against HIV-1 Lymphotropic PM16 clinical isolates in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID154761Cytotoxicity was measured against PBLs/HIV-1 (WEJO)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID155914Anti -HIV activity was measured against PMCs/HIV-1(Ba-L)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID403971Cytotoxicity against human CEM-SS cells1997Journal of natural products, Jul, Volume: 60, Issue:7
Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
AID403970Antiviral activity against HIV1 RF infected in human CEM-SS cells1997Journal of natural products, Jul, Volume: 60, Issue:7
Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
AID45370Anti-HIV activity was measured against HIV-2 ROD strain laboratory strains in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID1187989Inhibition of recombinant MraY overexpressed in Escherichia coli membranes at 500 uM after 30 mins by radiochemical assay in presence of [14C-D-Ala]-UDPMurNAc-pentapeptide2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID1187986Antimicrobial activity against Bacillus subtilis W23 by liquid culture microtitre plate assay2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID1187993Inhibition of recombinant Escherichia coli MurG at 500 ug/ml after 30 mins by radiochemical assay in presence of [3H]-UDPGlcNAc2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID1187988Inhibition of recombinant MraY overexpressed in Escherichia coli membranes at 100 uM after 30 mins by radiochemical assay in presence of [14C-D-Ala]-UDPMurNAc-pentapeptide2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID9466Cytotoxicity was measured against AA5/HIV-1(IIIB)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45369Anti-HIV activity was measured against HIV-2 NIH-DZ strain laboratory strains in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID106927Cytotoxicity was measured against MT-2/HIV-2(NIH-DZ)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID100082Anti -HIV activity was measured against LDV-7/HIV-1(RF)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID397755Antiviral activity against HIV1 in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect2001Journal of natural products, Feb, Volume: 64, Issue:2
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
AID1187982Inhibition of MraY in Pseudomonas aeruginosa membranes at 500 uM by continuous fluorescence assay2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID45355Anti -HIV activity was measured against CEM-SS/HIV-1 (RF)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID46564Cytotoxicity was measured against 174*CEM/HIV-1(IIIB)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45357Anti-HIV activity was measured against HIV-1 Lymphotropic G clinical isolates in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID1187991Antimicrobial activity against Micrococcus flavus at 1.95 to 125 ug/ml by liquid culture microtitre plate assay2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID46449Cytotoxicity was measured against CEM-SS/HIV-1 (NIH-DZ)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID44605Cytotoxicity was measured against C-344/HIV-1(RF)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID154636Anti -HIV activity was measured against PBLs/HIV-1 (WEJO)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID1187977Inhibition of recombinant MraY overexpressed in Escherichia coli membranes by continuous fluorescence assay2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID45360Anti-HIV activity was measured against HIV-1 Promonocytropic 214 clinical isolates in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID106889Anti -HIV activity was measured against MT-2/HIV-2(NIH-DZ)1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID1187978Inhibition of MraY in Bacillus subtilis membranes by continuous fluorescence assay2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID1187990Antimicrobial activity against Pseudomonas putida ATCC 33015 at 1.95 to 125 ug/ml by liquid culture microtitre plate assay2014Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17
Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B.
AID403972Antiviral activity against HIV1 OC100 infected in human CEM-SS cells1997Journal of natural products, Jul, Volume: 60, Issue:7
Michellamines D-F, new HIV-inhibitory dimeric naphthylisoquinoline alkaloids, and korupensamine E, a new antimalarial monomer, from Ancistrocladus korupensis.
AID45365Anti-HIV activity was measured against HIV-1,LAV laboratory strains in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45368Anti-HIV activity was measured against HIV-2 MS laboratory strains in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45356Anti-HIV activity was measured against HIV-1 Lymphotropic 205 clinical isolates in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
AID45366Anti-HIV activity was measured against HIV-1,RF laboratory strains in CEM-SS cells1994Journal of medicinal chemistry, Jun-10, Volume: 37, Issue:12
Anti-HIV michellamines from Ancistrocladus korupensis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's10 (58.82)18.2507
2000's2 (11.76)29.6817
2010's5 (29.41)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.78 (24.57)
Research Supply Index2.94 (2.92)
Research Growth Index4.73 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.56%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (94.44%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
quinoline
[no description available]		2.1710azaarene;
mancude organic heterobicyclic parent;
ortho-fused heteroarene;
quinolines
stavudine
Stavudine: A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.. stavudine : A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase		3.110dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.0210copper group element atom;
elemental silver		Escherichia coli metabolite
zalcitabine
Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.		3.110pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
nitidine chloride
[no description available]		3.110
nigericin
Nigericin: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed). nigericin : A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.		3.110polycyclic etherantibacterial agent;
antimicrobial agent;
bacterial metabolite;
potassium ionophore
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		3.520azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
lamivudine
[no description available]		3.110monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
kynostatin 272
kynostatin 272: structure given in first source; contains allophenylnorstatine as a transition-state mimic		3.110peptide
calanolide a
calanolide A: NSC 661122 and costatolide are isomers; a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum (Clusiaceae); structure in first source. (+)-calanolide A : An organic heterotetracyclic compound that is 11,12-dihydro-2H,6H,10H-dipyrano[2,3-f:2',3'-h]chromen-2-one substituted by a hydroxy group at position 12, methyl groups at positions 6, 6, 10 and 11 and a propyl group at position 4 (the 10R,11S,12S stereoisomer). Isolated from Calophyllum lanigerum var austrocoriaceum and Calophyllum brasiliense, it exhibits potent activity against HIV-1 reverse transcriptase.		3.110cyclic ether;
delta-lactone;
organic heterotetracyclic compound;
secondary alcohol		HIV-1 reverse transcriptase inhibitor;
plant metabolite
kynostatin 227
kynostatin 227: structure given in first source; contains allophenylnorstatine as a transition-state mimic		3.110
lodenosine
lodenosine: anti-HIV nucleoside analog, the flourine atom on lodenosine is located at 2-arabinoside location, while 2'-fluoro-2',3'-dideoxyadenosine has the flourine residue at the 2-ribose sugar location		3.110
korupensamine-b
korupensamine A: from Ancistrocladus and triphyophyllum; structure in first source		2.4320isoquinolines;
naphthalenes
12-deoxyphorbol 13-acetate
[no description available]		3.110phorbol estermetabolite
costatolide
(-)-calanolide B : An organic heterotetracyclic compound that is 11,12-dihydro-2H,6H,10H-dipyrano[2,3-f:2',3'-h]chromen-2-one substituted by a hydroxy group at position 12, methyl groups at positions 6, 6, 10 and 11 and a propyl group at position 4 (the 10S,11R,12S stereoisomer). Isolated from Calophyllum lanigerum var austrocoriaceum and Calophyllum brasiliense, it exhibits potent activity against HIV-1 reverse transcriptase.		3.110cyclic ether;
delta-lactone;
organic heterotetracyclic compound;
secondary alcohol		HIV-1 reverse transcriptase inhibitor;
plant metabolite
fumarprotocetraric acid
fumarprotocetraric acid: RN given refers to (E)-isomer; structure given in first source		3.110carbonyl compound
guttiferone a
guttiferone A: antibacterial from Clusiaceae family; structure in first source		3.110
pepstatin
pepstatin: inhibits the aspartic protease endothiapepsin		3.110pentapeptide;
secondary carboxamide		bacterial metabolite;
EC 3.4.23.* (aspartic endopeptidase) inhibitor
indigo carmine
3,5-di-O-(E)-caffeoylquinic acid: from roots of Lychnophora ericoides; structure in first source. 3,5-di-O-caffeoyl quinic acid : A carboxylic ester that is the diester obtained by the condensation of the hydroxy groups at positions 3 and 5 of (-)-quinic acid with the carboxy group of trans-caffeic acid. Isolated from Brazilian propolis and Suaeda glauca, it exhibits hepatoprotective and cytotoxic activities.		3.110
eosine i bluish
Eosine I Bluish: A red fluorescein dye used as a histologic stain. It may be cytotoxic, mutagenic, and inhibit certain mitochondrial functions.		2.110organic sodium saltfluorescent dye;
histological dye
didanosine
Didanosine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.. didanosine : A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.		3.110purine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor;
geroprotector;
HIV-1 reverse transcriptase inhibitor
conocurvone
conocurvone: a trimeric naphthoquinone derivative; extracted from Conospermum incurvum; structure given in first source		3.110organic heterotricyclic compound;
organooxygen compound
ConditionIndicatedRelationship StrengthStudiesTrials
HIV
Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.		02.3920