Page last updated: 2024-12-05

2-hydroxy benzimidazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-Hydroxy benzimidazole is a heterocyclic compound with potential biological activity. It is a white solid with a melting point of 201-203°C. The compound can be synthesized via various methods, including the reaction of o-phenylenediamine with formic acid or the condensation of o-aminophenol with formamide. 2-Hydroxy benzimidazole exhibits a range of biological activities, including antibacterial, antifungal, and anti-inflammatory properties. It is being investigated for its potential therapeutic applications in the treatment of infectious diseases and inflammatory conditions. Furthermore, it serves as a building block for the synthesis of various other bioactive compounds. The compound is also studied for its potential applications in materials science, as it can form complexes with metal ions and act as a ligand in coordination chemistry.'

2-hydroxy benzimidazole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11985
CHEMBL ID2152713
SCHEMBL ID37951
MeSH IDM0509868

Synonyms (95)

Synonym
HMS1783E17
ec 210-412-4
cv8118uzew ,
unii-cv8118uzew
BB 0242764
nsc178108
nsc-178108
2h-benzimidazol-2-one, 1,3-dihydro-
1,3-dihydro-2h-benzimidazol-2-one
AF-834/25000580
nsc 10383
urea, n,n'-(1,2-phenylene)-
2h-benzimidazol
nsc 178108
2(3h)-oxobenzimidazole
n,n'-(1,2-phenyleneurea)
ai3-60092
einecs 210-412-4
2-benzimidazolol
2-hydroxybenzimidazole
urea,n'-(1,2-phenylene)-
wln: t56 bnvnj
615-16-7
2-oxobenzimidazole
benzamidazole-2(3h)-one
2-benzimidazolone
2-.alpha.-hydroxybenzimidazole
nsc10383
n,2-phenyleneurea)
o-phenyleneurea
nsc-10383
2-benzimidazolinone
1,3-dihydrobenzimidazol-2-one
2(3h)-benzimidazolone
2-hydroxybenzimidazole, 97%
STK056075
AKOS000269651
silnnfmwimzveq-uhfffaoysa-
H0739
1,3-dihydro-benzoimidazol-2-one
AKOS015920049
1h-1,3-benzodiazol-2-ol
CHEMBL2152713 ,
bdbm50393071
2,3-dihydro-2-oxo-1h-benzimidazole
2-hydroxy-benzimidazol
2(1h)-benzimidazolone
102976-62-5
FT-0612581
2,3-dihydro-1h-1,3-benzodiazol-2-one
PS-5766
GF-0113
1,3-dihydro-2h-benzo[d]imidazol-2-one
F0728-0008
1h-benzo(d)imidazol-2-ol
lansoprazole impurity d
benzimidazolol [usp impurity]
lansoprazole impurity d [ep impurity]
rabeprazole sodium impurity k [ep impurity]
1,3-dihydro-2h-benzimidazole-2-one
STL360330
1h-benzimidazol-2-ol
SCHEMBL37951
1h-benzimidazol-2-one
benzimidazolinone
1h-benzo[d]imidazol-2(3h)-one
benzimidazol-2(3h)-one
2-hydroxybenzoimidazole
(3h)-benzimidazolone
2-hydroxy-1h-benzimidazole
2-hydroxy benzimidazole
1,3-dihydrobenzoimidazol-2-one
2,3-dihydrobenzimidazol-2-one
2,3-dihydro-1h-benzimidazole-2-one
benzimidazolin-2-one
azaoxindole
DTXSID0060642
lansoprazole ep impurity d
Q-101098
mfcd00127894
CS-W008003
Z56924489
1h-benzimidazol-2-ol(9ci)
SY033248
hydroxybenzimidazole
FT-0717793
BCP18291
o-phenylene urea
1h-benzo[d]imidazol-2-ol
Q818479
EN300-17387
F12393
STARBLD0016990
HY-W008003
PD065534
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
D-amino-acid oxidaseHomo sapiens (human)IC50 (µMol)100.00000.00401.119910.0000AID692851
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (8)

Processvia Protein(s)Taxonomy
proline catabolic processD-amino-acid oxidaseHomo sapiens (human)
digestionD-amino-acid oxidaseHomo sapiens (human)
D-amino acid catabolic processD-amino-acid oxidaseHomo sapiens (human)
D-serine catabolic processD-amino-acid oxidaseHomo sapiens (human)
dopamine biosynthetic processD-amino-acid oxidaseHomo sapiens (human)
D-alanine catabolic processD-amino-acid oxidaseHomo sapiens (human)
D-serine metabolic processD-amino-acid oxidaseHomo sapiens (human)
neutrophil-mediated killing of gram-negative bacteriumD-amino-acid oxidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (4)

Processvia Protein(s)Taxonomy
D-amino-acid oxidase activityD-amino-acid oxidaseHomo sapiens (human)
protein bindingD-amino-acid oxidaseHomo sapiens (human)
identical protein bindingD-amino-acid oxidaseHomo sapiens (human)
FAD bindingD-amino-acid oxidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (7)

Processvia Protein(s)Taxonomy
mitochondrial outer membraneD-amino-acid oxidaseHomo sapiens (human)
extracellular regionD-amino-acid oxidaseHomo sapiens (human)
cytoplasmD-amino-acid oxidaseHomo sapiens (human)
peroxisomal matrixD-amino-acid oxidaseHomo sapiens (human)
cytosolD-amino-acid oxidaseHomo sapiens (human)
cell projectionD-amino-acid oxidaseHomo sapiens (human)
presynaptic active zoneD-amino-acid oxidaseHomo sapiens (human)
cytoplasmD-amino-acid oxidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1893771Inhibition of recombinant human QC using H-Gln-AMC hydrobromide as fluorogenic substrate incubated for 6 hrs by fluorometric microplate reader analysis2022ACS medicinal chemistry letters, Sep-08, Volume: 13, Issue:9
2-Amino-1,3,4-thiadiazoles as Glutaminyl Cyclases Inhibitors Increase Phagocytosis through Modification of CD47-SIRPα Checkpoint.
AID1389532Inhibition of DAAO (unknown origin) at 20 uM2018Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors.
AID692851Inhibition of human recombinant DAAO expressed in HEK293 cells using D-serine as substrate after 20 mins by horseradish peroxidase-coupled assay2012ACS medicinal chemistry letters, Oct-11, Volume: 3, Issue:10
Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.96

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.96 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.72 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.96)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]