Assay ID | Title | Year | Journal | Article |
AID573109 | Antiviral activity against Hepatitis C virus genotype 1b infected in human Huh-9-13 cells assessed as reduction in replicon RNA after 4days by RT-qPCR analysis | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors. |
AID536905 | Antiviral activity against Hepatitis C virus subtype 1b with adaptive mutations of E1202G, T1280I, K1846T in NS5B polymerase infected in human HuH7 cells assessed as inhibition of viral replication after 3 days by luciferase assay | 2010 | Journal of medicinal chemistry, Nov-25, Volume: 53, Issue:22
| 2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase. |
AID475235 | Therapeutic index, ratio of CC50 for human HuH7 cells to EC50 for HCV 1b | 2010 | Journal of medicinal chemistry, Apr-22, Volume: 53, Issue:8
| Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication. |
AID348494 | Cytotoxicity against human HuH7 cells by XTT assay | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection. |
AID555947 | Antiviral activity against HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication selected after 5 passages at 4 uM by quantitative RT-PCR relative to wild type virus | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID573111 | Antiviral activity against Hepatitis C virus genotype 1b infected in human Huh-Mono cells assessed as reduction in replicon RNA after 4 days by RT-qPCR analysis | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors. |
AID1200154 | Antiviral activity against Respiratory syncytial virus subgenomic replicon system in 395 HeLa cells assessed as reduction in viral replication after 7 days by renilla luciferase assay | 2015 | Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
| Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. |
AID555953 | Antiviral activity against R479-resistant HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication after 3 days by quantitative RT-PCR | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID547287 | Selectivity ratio of EC90 for Hepatitis C virus harboring NS5B polymerase S96T mutant gene to EC90 for HCV harboring wild type NS5B polymerase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. |
AID514138 | Antiviral activity against HCV Con 1 by subgenomic replicon assay | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Studies on the anti-hepatitis C virus activity of newly synthesized tropolone derivatives: identification of NS3 helicase inhibitors that specifically inhibit subgenomic HCV replication. |
AID353350 | Cytotoxicity against human 2209-23 cells assessed as cell viability by WST-1 assay | 2009 | Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
| The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine. |
AID475233 | Antiviral activity against HCV 1b infected in human HuH7 cells assessed as inhibition of viral RNA replication after 4 days by replicon assay | 2010 | Journal of medicinal chemistry, Apr-22, Volume: 53, Issue:8
| Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication. |
AID547286 | Antiviral activity against Hepatitis C virus harboring NS5B polymerase S96T mutant gene infected in human lunet cells by luciferase-based replicon assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. |
AID520336 | Cytotoxicity against human HuH7 cells | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors. |
AID411722 | Cytotoxicity against human 2209-23 cells by WST1 cell ciability assay | 2009 | Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
| The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine. |
AID573112 | Cytotoxicity against human Huh5-2 cells after 3 days by MTT assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors. |
AID348493 | Antiviral activity against HCV subtype 1a in Huh7 cells assessed as reduction of viral RNA replication | 2008 | Bioorganic & medicinal chemistry, Oct-01, Volume: 16, Issue:19
| New acridone-4-carboxylic acid derivatives as potential inhibitors of hepatitis C virus infection. |
AID573106 | Cytotoxicity against human Huh-9-13 cells after 3 days by MTT assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors. |
AID306693 | Cytotoxicity against human 2209-23 cells at 20 uM | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. |
AID555946 | Antiviral activity against HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication selected after 7 passages at 15 uM by quantitative RT-PCR relative to wild type virus | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID555948 | Antiviral activity against HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication selected at 0.5 uM by quantitative RT-PCR | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID125167 | In vitro Cytotoxic concentration in mock-infected A3.01 cells. | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides. |
AID353351 | Antiproliferative activity against human 2209-23 cells assessed as [3H]thymidine incorporation by scintillation proximity assay | 2009 | Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
| The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine. |
AID547285 | Antiviral activity against Hepatitis C virus harboring wild-type NS5B infected in human lunet cells by luciferase-based replicon assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. |
AID306696 | Cytotoxicity against human 2209-23 cells | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. |
AID306697 | Cytostatic activity against human 2209-23 cells | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. |
AID547283 | Antiviral activity against Hepatitis C virus harboring NS5B polymerase S282T mutant gene infected in human HuH7 cells by luciferase-based replicon assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. |
AID555955 | Antiviral activity against VX 950-resistant HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication after 3 days by quantitative RT-PCR | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID573107 | Cytotoxicity against human Huh-Mono cells after 3 days by MTT assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors. |
AID536906 | Cytotoxicity against human HuH7 cells expressing CMV-Luc after 3 days by luciferase assay | 2010 | Journal of medicinal chemistry, Nov-25, Volume: 53, Issue:22
| 2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase. |
AID555945 | Antiviral activity against HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication selected after 5 passages at 4 uM by quantitative RT-PCR | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID306698 | Inhibition of HCV 1b BK NS5B570 RNA polymerase | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. |
AID573110 | Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH6 cells assessed as reduction in replicon RNA after 4days by RT-qPCR analysis | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors. |
AID547090 | Antiviral activity against Hepatitis C virus harboring NS5B polymerase S96T/N142T mutant gene infected in human HuH7 cells by luciferase-based replicon assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. |
AID7700 | Compound was tested in vitro for inhibition of cytopathogenicity of LAV(IIIB) in CD4+ T-cells (A3.01); Not active | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides. |
AID1497242 | Antiviral activity against Dengue virus 2 infected in human PBMC after 24 hrs post infection by plaque assay | 2018 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 28, Issue:13
| Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase. |
AID514139 | Cytotoxicity against human HuH7 cells | 2010 | Bioorganic & medicinal chemistry, Jul-15, Volume: 18, Issue:14
| Studies on the anti-hepatitis C virus activity of newly synthesized tropolone derivatives: identification of NS3 helicase inhibitors that specifically inhibit subgenomic HCV replication. |
AID555954 | Antiviral activity against BILN 2061-resistant HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication after 3 days by quantitative RT-PCR | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID411723 | Antiproliferative activity against human 2209-23 cells by [3H]thymidine incorporation scintillation proximity assay | 2009 | Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
| The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine. |
AID306695 | Antiviral activity against HCV 1b replicon in human 2209-23 cells | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. |
AID658633 | Competitive inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase | 2012 | Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10
| Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations. |
AID428151 | Antiviral activity against HCV Con1 GT1b by replicon assay | 2009 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 19, Issue:15
| The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479). |
AID353349 | Antiviral activity against HCV 1b infected in human 2209-23 cells by replicon assay | 2009 | Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
| The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine. |
AID573105 | Cytotoxicity against human HuH6 cells after 3 days by MTT assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors. |
AID573108 | Antiviral activity against Hepatitis C virus genotype 1b infected in human Huh5-2 cells assessed as reduction in replicon RNA after 4 days by luciferase assay | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors. |
AID555949 | Antiviral activity against HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication selected at 0.1 uM by quantitative RT-PCR | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID555944 | Antiviral activity against HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication selected after 7 passages at 15 uM by quantitative RT-PCR | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID547284 | Selectivity ratio of EC90 for Hepatitis C virus harboring NS5B polymerase S282T mutant gene to EC90 for Hepatitis C virus harboring wild-type NS5B polymerase | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. |
AID555950 | Antiviral activity against compound-resistant HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication after 3 days by quantitative RT-PCR | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID1200155 | Cytotoxicity against human HeLa cells assessed as cell viability by CellTiter-Glo luminescent assay | 2015 | Journal of medicinal chemistry, Feb-26, Volume: 58, Issue:4
| Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. |
AID411721 | Antiviral activity against Hepatitis C virus infected human 2209-23 cells by genotype 1b replicon assay | 2009 | Journal of medicinal chemistry, Jan-08, Volume: 52, Issue:1
| The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine. |
AID475234 | Cytotoxicity against human HuH7 cells after3 days by MTT assay | 2010 | Journal of medicinal chemistry, Apr-22, Volume: 53, Issue:8
| Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication. |
AID555951 | Antiviral activity against cyclosporine-resistant HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication after 3 days by quantitative RT-PCR | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID1497244 | Inhibition of human full length POLRMT using 32P-RNA primer/DNA template assessed as single nucleotide incorporation rate at 500 uM by SDS-PAGE analysis relative to CTP | 2018 | Bioorganic & medicinal chemistry letters, 07-15, Volume: 28, Issue:13
| Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase. |
AID520335 | Antiviral activity against Hepatitis C virus subtype 1b Con1 infected in human HuH7 cells after 3 days by luciferase reporter gene assay | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors. |
AID571733 | Antiviral activity against Hepatitis C virus infected in cells assessed as log reduction in viral RNA level from baseline at 4500 mg administered BID for 14 days by Replicon Assays | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors. |
AID555952 | Antiviral activity against 2'-C-methyl-2'-fluoro-cytidine-resistant HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication after 3 days by quantitative RT-PCR | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. |
AID125169 | In vitro Cytotoxic concentration in mock-infected A3.01 cells - 100% toxicity. | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Synthesis and anti-HIV activity of 4'-azido- and 4'-methoxynucleosides. |
AID547282 | Antiviral activity against Hepatitis C virus harboring wild-type NS5B infected in human HuH7 cells by luciferase-based replicon assay | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. |
AID306691 | Antiviral activity against HCV 1b replicon in human 2209-23 cells assessed as inhibition of viral replication at 20 uM | 2007 | Bioorganic & medicinal chemistry letters, May-01, Volume: 17, Issue:9
| Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. |
AID353348 | Inhibition of HCV NS5B polymerase-mediated RNA synthesis | 2009 | Journal of medicinal chemistry, May-14, Volume: 52, Issue:9
| The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine. |
AID536907 | Cytotoxicity against human MT4 cells expressing LTR-Luc after 3 days by luciferase assay | 2010 | Journal of medicinal chemistry, Nov-25, Volume: 53, Issue:22
| 2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |