| Assay ID | Title | Year | Journal | Article |
|---|
| AID346860 | Antimalarial activity as reduced parasitaemia against Plasmodium berghei ANKA infected CD1 mice (Mus musculus) after 4 days | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346852 | Inhibition of human recombinant CYP2C8 | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346875 | Clearance in iv and orally dosed mouse blood | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346856 | Inhibition of human recombinant CYP3A4 using N-N,diethyl-formamide as substrate | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346865 | Protein binding in mouse | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346858 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346848 | Elimination half life in orally dosed mouse | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346879 | Elimination half life in orally dosed monkey | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346859 | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346878 | Oral bioavailability in monkey | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID347270 | Ratio of drug level in blood to plasma in dog | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID1558342 | Cytotoxicity against BHK21 cells after 24 to 48 hrs by CCK8 assay | 2020 | Journal of medicinal chemistry, 01-23, Volume: 63, Issue:2
| Drugs for the Treatment of Zika Virus Infection. |
| AID346849 | Inhibition of human cloned ERG | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346851 | Inhibition of human recombinant CYP2C19 | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346845 | Oral bioavailability in mouse | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346847 | Clearance in iv and orally dosed rat blood | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID152136 | In vitro antimalarial activity against Plasmodium falciparum HB | 2003 | Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
| Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials. |
| AID346863 | Antimalarial activity as ED100 in peripheral blood at day 23 against Plasmodium yoelii 17X infected CD1 mice (Mus musculus) | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346855 | Inhibition of human recombinant CYP3A4 using phenyl-piperazinyl-methyl-benzyl-resofurin as substrate | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID347271 | Toxicity in monkey assessed as increase in QTc interval | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346850 | Inhibition of human recombinant CYP2D6 | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346880 | Protein binding in human | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346876 | Oral bioavailability in rat | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346861 | Antimalarial activity as reduced parasitaemia against Plasmodium yoelii 17X infected CD1 mice (Mus musculus) after 4 days | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346877 | Oral bioavailability in dog | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346866 | Clearance in iv and orally dosed monkey blood | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346846 | Clearance in iv and orally dosed dog blood | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID347037 | Ratio of drug level in blood to plasma in human | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID1558341 | Antiviral activity against Zika virus MR766 infected in African green monkey Vero cells by plaque assay | 2020 | Journal of medicinal chemistry, 01-23, Volume: 63, Issue:2
| Drugs for the Treatment of Zika Virus Infection. |
| AID152139 | In vitro antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 | 2003 | Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
| Isoquine and related amodiaquine analogues: a new generation of improved 4-aminoquinoline antimalarials. |
| AID346854 | Inhibition of human recombinant CYP1A2 | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346853 | Inhibition of human recombinant CYP2C9 | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346864 | Binding affinity to heme in DMSO assessed as equilibrium constant by UV-visible spectrophotometry | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| AID346857 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake | 2009 | Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
| Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |