| Assay ID | Title | Year | Journal | Article |
|---|
| AID394355 | Inhibition of heat-killed Staphylococcus aureus-induced c-jun mRNA expression in mouse BMDM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID594577 | Induction of quorum sensing activity in lasI/rhlI-deleted Pseudomonas aeruginosa PAO-JP2 expressing plasmid pKD201 containing a LasI reporter coupled to the luxCDABE assessed as relative luminescence units normalized with respect to cell viability at 1 uM | 2011 | Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9
| Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation. |
| AID152943 | Inhibition of human peripheral blood mononuclear cell (PBMC)donor C proliferation | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. |
| AID394351 | Inhibition of heat-killed Staphylococcus aureus-induced IL1-beta mRNA expression in mouse BMDM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394336 | Inhibition of LPS-induced IkappaBalpha mRNA expression in mouse alveolar macrophages after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394310 | Inhibition of LPS-induced p38 phosphorylation in mouse BMDM measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394737 | Inhibition of TNF-induced IkappaBalpha expression in human bronchial epithelial cells up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID595705 | Induction of lasR-mediated quorum sensing in Pseudomonas aeruginosa PAKR02 harboring lasB::luxCDABE gene assessed as lasR-induction ratio at 10'-4 M after 24 hrs by bioluminescence assay relative to control | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone. |
| AID394361 | Inhibition of TNF-induced IkappaBalpha expression in mouse MEF up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394335 | Inhibition of LPS-induced TNF mRNA expression in mouse C57BL/6 mouse alveolar macrophages up to 50 uM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394329 | Inhibition of LPS-induced IP-10 mRNA expression in mouse BMDM up to 3 hrs by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394305 | Effect on human TNF-alpha-stimulated IKK activity in human HeLa cells up to 50 uM using GST-IkappaBalpha (1 to 54) substrate by autoradiography | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID152940 | Inhibition of LPS-induced human TNF-alpha secretion | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. |
| AID1612766 | Antimigratory activity in human DU145 cells by wound healing assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394354 | Inhibition of heat-killed Staphylococcus aureus-induced B7h mRNA expression in mouse BMDM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID395856 | Agonist activity at Agrobacterium tumefaciens WCF47 TraR receptor by beta-galctosidase reporter gene assay | 2008 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
| Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators. |
| AID394749 | Inhibition of IkappaBalpha phosphorylation in human bronchial epithelial cells assessed after 2 hrs by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394324 | Effect on IKK activity in LPS-induced mouse BMDM assessed as induction of phosphorylation of CREB treated 2 hrs after LPS challenge measured up to 120 mins by immunoblot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394320 | Induction of IKK activity in mouse BMDM assessed as GST-IkappaBalpha phosphorylation by immunoprecipitation kinase assay | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612734 | Induction of apoptosis in human DU145 cells assessed as cell rounding at 10 uM after 24 hrs by Hoechst 33258 staining-based fluorescence microscopic analysis | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394741 | Inhibition of TNF-induced p38 phosphorylation in human bronchial epithelial cells up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612727 | Inhibition of colony formation in human DU145 cells after 21 days by crystal violet staining-based assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID1404693 | Agonist activity at Pseudomonas aeruginosa QscR expressed in Escherichia coli JLD271 harboring QscR expression plasmid pJN105Q and pPA1897-lacZ transcriptional fusion reporter pSC11-Q measured after 35 mins by Miller-type beta-galactosidase reporter gene | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19
| A comparative study of non-native N-acyl l-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence. |
| AID394315 | Inhibition of LPS-induced IkappaBalpha phosphorylation in human THP1 cells measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID495889 | Antibacterial activity against Clostridium difficile 3 assessed as inhibition of bacterial viability at 50 uM after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers. |
| AID394345 | Inhibition of LPS-induced IP-10 mRNA expression in MEF after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394334 | Inhibition of LPS-induced IRF-1 mRNA expression in mouse BMDM up to 3 hrs by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612723 | Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394337 | Inhibition of LPS-induced c-jun mRNA expression in mouse alveolar macrophages after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1129187 | Noncompetitive inhibition of AgrC-I in AIP-1-induced Staphylococcus aureus RN6390B at 25 to 100 uM after 55 mins by kinetic study | 2014 | Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6
| Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors. |
| AID263584 | Induction of apoptosis in P388D1 cell line | 2006 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8
| Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages. |
| AID394312 | Inhibition of LPS-induced IkappaBalpha phosphorylation in C57BL/6 mouse alveolar macrophages measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID732063 | Inhibition of Staphylococcus aureus RN6390B Agr-mediated RNA3 promoter activation measured up to 6 hrs by Northern blot analysis | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4
| Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective. |
| AID1612741 | Induction of apoptosis in human DU145 cells assessed as formation of apoptotic bodies at 10 uM after 24 hrs by Hoechst 33258 staining-based fluorescence microscopic analysis | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394348 | Effect on IFN-gamma-induced IRF-1 mRNA expression in mouse BMDM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394308 | Inhibition of LPS-induced IkappaBalpha expression in mouse BMDM measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394347 | Effect on IFN-gamma-induced IP-10 mRNA expression in mouse BMDM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612748 | Induction of apoptosis in human DU145 cells assessed as late apoptotic cells at 10 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 0.2%) | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID393543 | Cytotoxicity against human NCI-H630 cells after 5 days by SRB assay | 2009 | Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6
| Microwave synthesis and evaluation of phenacylhomoserine lactones as anticancer compounds that minimally activate quorum sensing pathways in Pseudomonas aeruginosa. |
| AID394350 | Inhibition of heat-killed Staphylococcus aureus-induced TNF mRNA expression in mouse BMDM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394356 | Effect on TNF-induced IkappaBalpha mRNA expression in MEF by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612725 | Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID1612753 | Induction of apoptosis in human DU145 cells assessed as necrotic cells at 10 uM after 24 hrs in presence of TRAIL by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 1.6%) | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID1604888 | Activation of LasR in Escherichia coli JLD271 harboring pSC11/pJN105L using CPRG as substrate incubated for 4 hrs by Miller assay method | 2020 | Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3
| Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria. |
| AID142576 | Inhibition of murine splenocyte proliferation | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. |
| AID394735 | Inhibition of TNF-induced p38 phosphorylation in mouse MEF up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID612760 | Hydrolytic stability of the compound in Luria-Bertani medium containing Pseudomonas aeruginosa PA01 MW1 (pUM15) assessed as half life by measuring YFP fluorescence | 2011 | Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16
| Thiolactone modulators of quorum sensing revealed through library design and screening. |
| AID1612742 | Induction of apoptosis in human DU145 cells assessed as formation of apoptotic bodies at 10 uM after 24 hrs in presence of TRAIL by Hoechst 33258 staining-based fluorescence microscopic analysis | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID1612751 | Induction of apoptosis in human DU145 cells assessed as early apoptotic cells at 10 uM after 24 hrs in presence of TRAIL by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 0.3%) | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394745 | Induction of apoptosis in TNF-stimulated human bronchial epithelial cells assessed as PARP cleavage after 2 hrs by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1453673 | Inhibition of NF-kappaB (unknown origin) expressed in human L428 cells after 2 hrs by luciferase reporter gene assay | 2017 | Bioorganic & medicinal chemistry letters, 07-01, Volume: 27, Issue:13
| Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-κB signaling. |
| AID394742 | Suppression of LPS-induced TNF expression in C57BL/6 transgenic mouse bearing TNF-reporter after 2 hrs by luciferase reporter gene assay | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394322 | Inhibition of IKK activity in LPS-induced mouse BMDM assessed as reduction in phosphorylation of IkappaBalpha treated 2 hrs after LPS challenge measured up to 120 mins by immunoblot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612752 | Induction of apoptosis in human DU145 cells assessed as late apoptotic cells at 10 uM after 24 hrs in presence of TRAIL by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 0.2%) | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID597146 | Cytotoxicity against human Jurkat E6-1 cells assessed as cell viability after 24 hrs by trypan blue exclusion assay | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone. |
| AID318815 | Agonist activity at Pseudomonas aeruginosa QscR expressed in Escherichia coli assessed as production of beta-galactosidase | 2008 | Bioorganic & medicinal chemistry letters, May-15, Volume: 18, Issue:10
| Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa. |
| AID394360 | Inhibition of TNF-induced IkappaBalpha phosphorylation in mouse MEF up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID594575 | Induction of phosphorylation of eIF2alpha in mouse BMDM cells at 50 uM after 90 mins by Western blot analysis | 2011 | Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9
| Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation. |
| AID1612750 | Induction of apoptosis in human DU145 cells assessed as viable cells at 10 uM after 24 hrs in presence of TRAIL by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 97.9%) | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID597147 | Immunosuppressive activity in mouse concanavalin A-stimulated peripheral blood leukocyte assessed as inhibition of leukocyte proliferation by [3H]thymidine incorporation assay | 2011 | Journal of medicinal chemistry, May-12, Volume: 54, Issue:9
| Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone. |
| AID394753 | Inhibition of LPS-induced TNF production in human whole blood after 3 hrs | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394736 | Inhibition of TNF-induced IkappaBalpha phosphorylation in human bronchial epithelial cells up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394326 | Inhibition of LPS-induced IkappaBalpha mRNA expression in mouse BMDM up to 3 hrs by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID495888 | Antibacterial activity against Clostridium difficile 2 assessed as inhibition of bacterial viability at 50 uM after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers. |
| AID1129179 | Inhibition of AIP-1-induced AgrC-I activation in Staphylococcus aureus RN6390B after 55 mins by beta-lactamase reporter assay | 2014 | Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6
| Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors. |
| AID394307 | Inhibition of LPS-induced IkBbeta protein level in mouse BMDM treated 2 hrs after LPS challenge measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID594521 | Induction of PARP cleavage in mouse BMDM cells at 50 uM after 90 mins by Western blot analysis | 2011 | Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9
| Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation. |
| AID394349 | Inhibition of heat-killed Staphylococcus aureus-induced IkappaBalpha mRNA expression in mouse BMDM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394339 | Inhibition of LPS-induced RANTES mRNA expression in mouse alveolar macrophages after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1604886 | Activation of LasR in Pseudomonas aeruginosa PAO-JP2 harboring plasI-LVAgfp incubated for 6 hrs by fluorescence method | 2020 | Bioorganic & medicinal chemistry, 02-01, Volume: 28, Issue:3
| Impact of the structure-activity relationship of AHL analogues on quorum sensing in Gram-negative bacteria. |
| AID394357 | Effect on TNF-induced MCP1 mRNA expression in MEF by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394733 | Inhibition of TNF-induced RelA phosphorylation in mouse MEF up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612746 | Induction of apoptosis in human DU145 cells assessed as viable cells at 10 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 97.9%) | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394353 | Inhibition of heat-killed Staphylococcus aureus-induced RANTES mRNA expression in mouse BMDM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID318814 | Agonist activity at Pseudomonas aeruginosa QscR expressed in Escherichia coli assessed as production of beta-galactosidase at 5 uM relative to dodecanoyl homoserine lactone | 2008 | Bioorganic & medicinal chemistry letters, May-15, Volume: 18, Issue:10
| Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa. |
| AID1612749 | Induction of apoptosis in human DU145 cells assessed as necrotic cells at 10 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 1.6%) | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394328 | Inhibition of LPS-induced MCP-1 mRNA expression in mouse BMDM up to 3 hrs by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394744 | Induction of apoptosis in TNF-stimulated human WI38 fibroblast assessed as PARP cleavage after 2 hrs by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612733 | Growth inhibition of human DU145 cells at 5 uM after 72 hrs in presence of TRAIL by MTT assay relative to control | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID1200793 | Cytotoxicity against human EC9706 cells after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Discovery of novel AHLs as potent antiproliferative agents. |
| AID495902 | Induction of lipid membranes composition changes in Clostridium difficile by NMR spectroscopy | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers. |
| AID394755 | Inhibition of LPS-induced IkappaBalpha mRNA expression in mouse C57BL/6 mouse alveolar macrophages up to 50 uM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394747 | Inhibition of IkappaBalpha phosphorylation in human WI38 cells assessed after 2 hrs by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID152942 | Inhibition of human peripheral blood mononuclear cell (PBMC)donor B proliferation | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. |
| AID495896 | Antibacterial activity against Clostridium difficile assessed as induction of changes in cell surface structures by electron microscopy | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers. |
| AID394743 | Suppression of LPS-induced TNF expression in C57BL/6 transgenic mouse bearing IkappaBalpha-reporter after 2 hrs by luciferase reporter gene assay | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394359 | Effect on TNF-induced c-jun mRNA expression in MEF by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID613915 | Modulation of Pseudomonas aeruginosa lacZ-fused lasI expressed in Escherichia coli DH5alpha co-expressing pBAD-lasR at 0.002 mM after 3 hrs by beta-galactosidase assay relative to control | 2011 | Bioorganic & medicinal chemistry, Sep-15, Volume: 19, Issue:18
| Substituted lactam and cyclic azahemiacetals modulate Pseudomonas aeruginosa quorum sensing. |
| AID1404698 | Selectivity ratio of EC50 for agonist activity at Pseudomonas aeruginosa QscR to EC50 for agonist activity at Pseudomonas aeruginosa LasR | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19
| A comparative study of non-native N-acyl l-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence. |
| AID1612738 | Induction of apoptosis in human DU145 cells assessed as chromatin shrinkage at 10 uM after 24 hrs by Hoechst 33258 staining-based fluorescence microscopic analysis | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394746 | Inhibition of IkappaBalpha in human WI38 cells assessed after 2 hrs by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1200792 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Discovery of novel AHLs as potent antiproliferative agents. |
| AID393544 | Cytotoxicity against 5FU-resistant human NCI-H630 cells after 5 days by SRB assay | 2009 | Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6
| Microwave synthesis and evaluation of phenacylhomoserine lactones as anticancer compounds that minimally activate quorum sensing pathways in Pseudomonas aeruginosa. |
| AID394327 | Inhibition of LPS-induced c-jun mRNA expression in mouse BMDM up to 3 hrs by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394333 | Inhibition of LPS-induced TNF mRNA expression in mouse BMDM up to 3 hrs by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394748 | Inhibition of IkappaBalpha in human bronchial epithelial cells assessed after 2 hrs by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID495890 | Antibacterial activity against Clostridium difficile 4 assessed as inhibition of bacterial viability at 50 uM after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers. |
| AID152941 | Inhibition of human peripheral blood mononuclear cell (PBMC)donor A proliferation | 2003 | Journal of medicinal chemistry, Jan-02, Volume: 46, Issue:1
| Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. |
| AID393547 | Toxicity assessed as activation of quorum sensing signalling in Pseudomonas aeruginosa MW1 carrying (lasI-,rhlI-) pUM15 containing rsa::gfp fusion gene at 0.3 uM by LasR-dependent green fluorescence protein reporter assay | 2009 | Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6
| Microwave synthesis and evaluation of phenacylhomoserine lactones as anticancer compounds that minimally activate quorum sensing pathways in Pseudomonas aeruginosa. |
| AID1612763 | Induction of apoptosis in human DU145 cells assessed as increase in caspase-3/7 activity at 10 to 50 uM after 24 hrs by Caspase-Glo 3/7 assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394317 | Inhibition of LPS-induced RelA phosphorylation in mouse BMDM treated 2 hrs after LPS challenge measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612747 | Induction of apoptosis in human DU145 cells assessed as early apoptotic cells at 10 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 0.3%) | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394332 | Inhibition of LPS-induced IL-12beta mRNA expression in mouse BMDM up to 3 hrs by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394344 | Inhibition of LPS-induced RANTES mRNA expression in MEF after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394341 | Inhibition of LPS-induced IRF-1 mRNA expression in mouse alveolar macrophages after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394754 | Induction of c-jun mRNA expression in mouse BMDM at 50 uM after 2 hrs by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1129178 | Antimicrobial activity against Staphylococcus aureus RN6390B assessed as growth inhibition after 18 hrs by spectrophotometry | 2014 | Journal of medicinal chemistry, Mar-27, Volume: 57, Issue:6
| Targeting Staphylococcus aureus quorum sensing with nonpeptidic small molecule inhibitors. |
| AID394316 | Inhibition of LPS-induced p38 phosphorylation in human THP1 cells measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394313 | Inhibition of LPS-induced p38 phosphorylation in C57BL/6 mouse alveolar macrophages measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394342 | Inhibition of LPS-induced IkappaBalpha mRNA expression in MEF after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612731 | Growth inhibition of human DU145 cells at 5 uM after 24 to 48 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394358 | Effect on TNF-induced RANTES mRNA expression in MEF by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394740 | Inhibition of TNF-induced RelA expression in human bronchial epithelial cells up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394512 | Inhibition of TNF-induced IkappaBbeta expression in mouse MEF up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394314 | Inhibition of LPS-induced IkappaBalpha expression in human THP1 cells measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612736 | Induction of apoptosis in human DU145 cells assessed as cell rounding at 10 uM after 24 hrs in presence of TRAIL by Hoechst 33258 staining-based fluorescence microscopic analysis | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394346 | Inhibition of LPS-induced c-jun mRNA expression in MEF after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394752 | Inhibition of LPS-induced IL-12beta mRNA expression in mouse alveolar macrophages after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394331 | Inhibition of LPS-induced RANTES mRNA expression in mouse BMDM up to 3 hrs by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394330 | Inhibition of LPS-induced IFNbeta mRNA expression in mouse BMDM up to 3 hrs by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394750 | Inhibition of LPS-induced TNF mRNA expression in human PBMC up to 50 uM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID615273 | Agonist activity at Pseudomonas aeruginosa LasR cognate receptor expressed in Escherichia coli harboring pKDT17 assessed as activation of lasB expression by LacZ reporter gene assay | 2010 | Journal of medicinal chemistry, Nov-11, Volume: 53, Issue:21
| Medicinal chemistry as a conduit for the modulation of quorum sensing. |
| AID394340 | Inhibition of LPS-induced TNF mRNA expression in mouse alveolar macrophages after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID393545 | Cytotoxicity against human PC3 cells after 5 days by SRB assay | 2009 | Journal of medicinal chemistry, Mar-26, Volume: 52, Issue:6
| Microwave synthesis and evaluation of phenacylhomoserine lactones as anticancer compounds that minimally activate quorum sensing pathways in Pseudomonas aeruginosa. |
| AID394738 | Inhibition of TNF-induced IkappaBbeta expression in human bronchial epithelial cells up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612764 | Induction of apoptosis in human DU145 cells assessed as increase in caspase-3/7 activity at 10 uM after 24 hrs in presence of TRAIL by Caspase-Glo 3/7 assay relative to control | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID495887 | Antibacterial activity against Clostridium difficile 1 assessed as inhibition of bacterial viability at 50 uM after 24 hrs | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers. |
| AID1612732 | Growth inhibition of human DU145 cells at 5 uM by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID394739 | Inhibition of TNF-induced RelA phosphorylation in human bronchial epithelial cells up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394323 | Inhibition of IKK activity in LPS-induced mouse BMDM assessed as reduction in phosphorylation of RelA treated 2 hrs after LPS challenge measured up to 120 mins by immunoblot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394306 | Effect on IKK activity in LPS-induced mouse BMDM assessed as induction of phosphorylation of p38 treated 2 hrs after LPS challenge measured up to 120 mins by immunoblot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394343 | Inhibition of LPS-induced MCP-1 mRNA expression in MEF after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1404692 | Agonist activity at Pseudomonas aeruginosa LasR expressed in Escherichia coli JLD271 harboring LasR expression plasmid pJN105L and lasI-lacZ transcriptional fusion reporter pSC11-L measured after 35 mins by Miller-type beta-galactosidase reporter gene ass | 2018 | Bioorganic & medicinal chemistry, 10-15, Volume: 26, Issue:19
| A comparative study of non-native N-acyl l-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence. |
| AID394321 | Inhibition of LPS-induced IKK activity in mouse BMDM assessed as GST-IkappaBalpha phosphorylation after 5 mins by immunoprecipitation kinase assay | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394318 | Inhibition of LPS-induced IkBbeta degradation in mouse BMDM treated 2 hrs after LPS challenge measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612724 | Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID1200794 | Cytotoxicity against human SMMC7721 cells after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Discovery of novel AHLs as potent antiproliferative agents. |
| AID394311 | Inhibition of LPS-induced IkappaBalpha expression in C57BL/6 mouse alveolar macrophages measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612726 | Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID395858 | Agonist activity at Vibrio fischeri ES114 LuxR receptor by luciferase reporter gene assay | 2008 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
| Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators. |
| AID394734 | Inhibition of TNF-induced RelA expression in mouse MEF up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1782639 | Synergistic anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability at 50 uM pretreated for 3 hrs followed by TRAIL stimulation measured after 24 hrs | | | |
| AID394309 | Inhibition of LPS-induced IkappaBalpha phosphorylation in mouse BMDM measured up to 120 mins by Western blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1782638 | Synergistic anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability at 25 uM pretreated for 3 hrs followed by TRAIL stimulation measured after 24 hrs | | | |
| AID394319 | Inhibition of LPS-induced RelA phosphorylation in [32P]orthophosphate metabolically labelled mouse BMDM assessed as phosphorylated IkappaBbeta/RelA binding measured up to 120 mins in absence of IkappaBalpha by SDS-PAGE and autoradiography | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394338 | Inhibition of LPS-induced IP-10 mRNA expression in mouse alveolar macrophages after 90 mins by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1612739 | Induction of apoptosis in human DU145 cells assessed as chromatin shrinkage at 10 uM after 24 hrs in presence of TRAIL by Hoechst 33258 staining-based fluorescence microscopic analysis | 2019 | European journal of medicinal chemistry, Feb-01, Volume: 163 | Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation. |
| AID1200791 | Cytotoxicity against human MGC803 cells after 72 hrs by MTT assay | 2015 | European journal of medicinal chemistry, Mar-26, Volume: 93 | Discovery of novel AHLs as potent antiproliferative agents. |
| AID395857 | Agonist activity at Escherichia coli DH5alpha LasR receptor by beta-galctosidase reporter gene assay | 2008 | Bioorganic & medicinal chemistry letters, Nov-15, Volume: 18, Issue:22
| Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators. |
| AID1329814 | Agonist activity at Pseudomonas aeruginosa GFP-fused LasR expressed in Escherichia coli BL21(DE3) after 4 to 6 hrs by fluorescence assay | 2017 | Bioorganic & medicinal chemistry, 01-01, Volume: 25, Issue:1
| Development of a novel series of non-natural triaryl agonists and antagonists of the Pseudomonas aeruginosa LasR quorum sensing receptor. |
| AID394352 | Inhibition of heat-killed Staphylococcus aureus-induced MCP-1 mRNA expression in mouse BMDM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID594576 | Induction of phosphorylation of p38 in mouse BMDM cells at 50 uM after 90 mins by Western blot analysis | 2011 | Bioorganic & medicinal chemistry letters, May-01, Volume: 21, Issue:9
| Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation. |
| AID394325 | Effect on His-tagged IKK-beta E177/181 mutant activity expressed in Sf9 cells up to 50 uM using GST-IkappaBalpha (1 to 54) substrate by autoradiography | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID394751 | Inhibition of LPS-induced IkappaBalpha mRNA expression in human PBMC up to 50 uM by Northern blot analysis | 2008 | Science (New York, N.Y.), Jul-11, Volume: 321, Issue:5886
| Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule. |
| AID1202949 | Agonist activity at Pseudomonas aeruginosa LasR | 2015 | ACS medicinal chemistry letters, Feb-12, Volume: 6, Issue:2
| Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |