davunetide has been researched along with dodecylphosphocholine* in 1 studies
1 other study(ies) available for davunetide and dodecylphosphocholine
Article | Year |
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Short neuroprotective peptides, ADNF9 and NAP, are structurally disordered and monomeric in PBS.
Activity-dependent neurotrophic factor 9 (ADNF9) and NAP are nine and eight amino acid peptides, which exhibit neuroprotective activity at femtomolar concentrations against cell toxic agents. We have here characterized their structures and interactions with dodecylphosphocholine (DPC) in phosphate-buffered saline (PBS). Circular dichroism analysis showed that ADNF9 and NAP are structurally disordered in PBS independent of peptide concentration and temperature, but appear to assume different secondary structure at increasing temperature. Sedimentation equilibrium analysis showed that both ADNF9 and NAP are monomeric at 37 degrees C, suggesting no self-association under physiological conditions. No secondary structure changes were observed in the presence of DPC, suggesting that ADNF9 and NAP do not interact with lipids. Topics: Circular Dichroism; Molecular Weight; Nerve Growth Factors; Neuroprotective Agents; Oligopeptides; Phosphorylcholine; Temperature; Ultracentrifugation | 2009 |