Page last updated: 2024-09-28

Dependent Personality Disorder

A personality disorder characterized by a pervasive and excessive need to be taken care of that leads to submissive and clinging behavior and fears of separation, beginning by early adulthood and present in a variety of contexts. (From DSM-IV, 1994)

Synonyms(3)

Synonym
Passive-Dependent Personality
Personality Disorder, Dependent
Dependent Personality Disorder

Research

Studies (19)

TimeframeStudies, This Condition (%)All Conditions %
pre-199013 (68.42)23.3326
1990's4 (21.05)12.5806
2000's0 (0.00)18.1394
2010's2 (10.53)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
nitrous oxide0low10
3,4-methylenedioxyamphetamine0low20
amitriptyline0low10
diazepam0medium11
furosemide0low10
lorazepam0low10
methadone0low10
zopiclone0low10
dextroamphetamine0low10
s,n,n'-tripropylthiocarbamate0low10
4-methoxyamphetamine0low30
cocaine0low10
cyproterone0low10
sodium ethylxanthate0low10
ego0low30

Protein Targets (293)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
5-hydroxytryptamine receptor 2C0538
5-hydroxytryptamine receptor 2A0538
5-hydroxytryptamine receptor 1A06410
Sodium-dependent noradrenaline transporter 0819
Sodium-dependent dopamine transporter0224
5-hydroxytryptamine receptor 1B0437
5-hydroxytryptamine receptor 1D0336
5-hydroxytryptamine receptor 1F0336
5-hydroxytryptamine receptor 2B0538
5-hydroxytryptamine receptor 60235
Sodium-dependent serotonin transporter08311
Sodium-dependent serotonin transporter0427
5-hydroxytryptamine receptor 7 0235
5-hydroxytryptamine receptor 5A0235
5-hydroxytryptamine receptor 5B0235
5-hydroxytryptamine receptor 3A0235
Sodium-dependent dopamine transporter 0819
5-hydroxytryptamine receptor 4 0235
5-hydroxytryptamine receptor 3B0235
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
thioredoxin reductase1001
USP1 protein, partial1001
NFKB1 protein, partial1001
GLS protein1001
cytochrome P450 family 3 subfamily A polypeptide 44004
cytochrome P450 2D61001
arylsulfatase A1001
cytochrome P450 2D6 isoform 11001
D(1A) dopamine receptor1001
chromobox protein homolog 11001
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 13003
muscarinic acetylcholine receptor M11001
Solute carrier family 22 member 1 0101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Voltage-dependent L-type calcium channel subunit alpha-1F0303
5-hydroxytryptamine receptor 40202
Bile salt export pump0404
Albumin0022
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40101
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0202
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10202
Angiotensin-converting enzyme0202
D(2) dopamine receptor0303
Alpha-2B adrenergic receptor0202
Alpha-2C adrenergic receptor0202
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0202
D(1B) dopamine receptor0101
UDP-glucuronosyltransferase 1A40001
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Histamine H1 receptor0101
Histamine H1 receptor0202
D(3) dopamine receptor0303
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0101
Histamine H2 receptor1103
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
5-hydroxytryptamine receptor 70101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Potassium voltage-gated channel subfamily H member 20404
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0101
Sigma non-opioid intracellular receptor 10011
Nuclear receptor subfamily 3 group C member 3 0202
Canalicular multispecific organic anion transporter 10303
Sodium channel protein type 2 subunit alpha0101
Ataxin-22002
Sigma non-opioid intracellular receptor 10404
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0101
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0303
Gamma-aminobutyric acid receptor subunit delta0303
Amyloid-beta precursor protein0101
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Tryptophan 5-hydroxylase 10101
Gamma-aminobutyric acid receptor subunit alpha-10325
Gamma-aminobutyric acid receptor subunit beta-10303
Gamma-aminobutyric acid receptor subunit gamma-20314
D0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Liver carboxylesterase 10001
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30314
Gamma-aminobutyric acid receptor subunit alpha-50325
Gamma-aminobutyric acid receptor subunit alpha-30314
Glutamate receptor ionotropic, NMDA 1 0101
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit beta-20314
Gamma-aminobutyric acid receptor subunit alpha-40303
D(2) dopamine receptor0101
Gamma-aminobutyric acid receptor subunit epsilon0303
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60303
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0101
Gamma-aminobutyric acid receptor subunit gamma-10303
Glutamate receptor ionotropic, NMDA 3B0101
Gamma-aminobutyric acid receptor subunit gamma-30303
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0101
Gamma-aminobutyric acid receptor subunit theta0303
Transporter0202
TDP1 protein3003
AR protein5005
glucocorticoid receptor [Homo sapiens]3003
estrogen nuclear receptor alpha5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a3003
nuclear receptor subfamily 1, group I, member 21001
peripheral myelin protein 221001
Phenylethanolamine N-methyltransferase0101
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] A0101
Amine oxidase [flavin-containing] B0101
Amine oxidase [flavin-containing] B0101
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Sigma non-opioid intracellular receptor 10011
Gamma-aminobutyric acid 0101
glp-1 receptor, partial1001
GLI family zinc finger 32002
estrogen receptor 2 (ER beta)3003
nuclear receptor subfamily 1, group I, member 32002
progesterone receptor2002
estrogen-related nuclear receptor alpha3003
pregnane X nuclear receptor2002
G1001
peroxisome proliferator activated receptor gamma2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
thyroid hormone receptor beta isoform 23003
Gamma-aminobutyric acid receptor subunit pi0314
Voltage-dependent calcium channel gamma-2 subunit1001
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Fatty acid-binding protein, liver0202
Alpha-1-acid glycoprotein 10001
Albumin0113
Cellular tumor antigen p531001
ATP-dependent translocase ABCB10102
Gamma-aminobutyric acid receptor subunit alpha-10202
Gamma-aminobutyric acid receptor subunit beta-10202
Neuronal acetylcholine receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit alpha-20202
Gamma-aminobutyric acid receptor subunit alpha-30202
Neuronal acetylcholine receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit beta-10314
Translocator protein0113
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit delta0314
Gamma-aminobutyric acid receptor subunit gamma-20314
Glutamate receptor 21001
Gamma-aminobutyric acid receptor subunit alpha-50314
Gamma-aminobutyric acid receptor subunit alpha-30314
Gamma-aminobutyric acid receptor subunit alpha-40202
Gamma-aminobutyric acid receptor subunit gamma-20202
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid receptor subunit gamma-10314
Gamma-aminobutyric acid receptor subunit alpha-20314
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40314
Gamma-aminobutyric acid receptor subunit gamma-30314
Gamma-aminobutyric acid receptor subunit alpha-60314
Translocator protein0101
Translocator protein0202
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit alpha-10314
Gamma-aminobutyric acid receptor subunit beta-30314
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit beta-20314
Neuronal acetylcholine receptor subunit alpha-70101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit pi0101
Sphingosine-1-phosphate lyase 10101
GABA theta subunit0314
Inositol hexakisphosphate kinase 11001
ATPase family AAA domain-containing protein 51001
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit epsilon0314
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid receptor subunit gamma-10101
cytochrome P450 2C9, partial1001
RAR-related orphan receptor gamma2002
aldehyde dehydrogenase 1 family, member A11001
EWS/FLI fusion protein1001
retinoic acid nuclear receptor alpha variant 12002
farnesoid X nuclear receptor2002
aryl hydrocarbon receptor1001
thyrotropin-releasing hormone receptor1001
geminin1001
Solute carrier family 22 member 60101
Carbonic anhydrase 120102
Bile salt export pump0101
Carbonic anhydrase 10102
Carbonic anhydrase 20102
Carbonic anhydrase 30101
Glucose-6-phosphate 1-dehydrogenase0101
Cytochrome P450 2C9 0101
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Serum paraoxonase/arylesterase 10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 70102
Adenosine receptor A10101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Cytochrome P450 2J20101
6-phosphogluconate dehydrogenase, decarboxylating0101
Spike glycoprotein1001
Holo-[acyl-carrier-protein] synthase0101
Solute carrier organic anion transporter family member 2A10101
Sodium/bile acid cotransporter0101
Carbonic anhydrase 90102
Multidrug and toxin extrusion protein 10101
Carbonic anhydrase 130102
G-protein coupled receptor 350112
CDGSH iron-sulfur domain-containing protein 10202
Carbonic anhydrase 140102
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Carbonic anhydrase 5B, mitochondrial0102
potassium voltage-gated channel subfamily H member 2 isoform d1001
lamin isoform A-delta101001
Cytochrome P450 2B60101
D(4) dopamine receptor0101
Mu-type opioid receptor0202
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
Mas-related G-protein coupled receptor member X20011
Aldehyde oxidase 1 0101
thyroid hormone receptor beta isoform a1001
Luciferase1001
hypoxia-inducible factor 1 alpha subunit1001
retinoid X nuclear receptor alpha1001
peroxisome proliferator-activated receptor delta1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
Histone H2A.x1001
Caspase-71001
caspase-31001
heat shock protein beta-11001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Microtubule-associated protein tau1001
67.9K protein1001
euchromatic histone-lysine N-methyltransferase 21001
muscleblind-like protein 1 isoform 11001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]