Page last updated: 2024-09-27

Cone-Rod Degenerations

Genetically heterogeneous and sometimes syndromic (e.g., BARDET BIEDL SYNDROME; and SPINOCEREBELLAR ATAXIA TYPE 7) retinopathies with initial RETINAL CONE involvement. They are characterized by decreased VISUAL ACUITY; COLOR VISION DEFECTS; progressive loss of peripheral vision and night blindness.

Synonyms(8)

Synonym
Rod-Cone Dystrophy
Retinal Cone-Rod Dystrophy
Rod Cone Dystrophies
Cone-Rod Dystrophy 2
Cone-Rod Dystrophy
Cone-Rod Dystrophies
Cone-Rod Retinal Dystrophy
Cone-Rod Degenerations

Research

Studies (19)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's8 (42.11)28.8240
2020's11 (57.89)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
vorinostat0low10
glutamic acid0low20
fomesafen0low10
trichostatin a0low10
11-cis-retinal0low10
glycolipids0low10
cyclic gmp0low20
guanosine triphosphate0low20
eye0low10

Protein Targets (313)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Retinaldehyde-binding protein 10011
Chain A, Retinaldehyde-binding protein 10011
Chain A, CARBONIC ANHYDRASE IV0101
Carbonic anhydrase 0001
Carbonic anhydrase 0101
RAR-related orphan receptor gamma3003
TDP1 protein4004
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 70002
cytochrome P450 family 3 subfamily A polypeptide 42002
cytochrome P450 2D63003
Carbonic anhydrase 0101
Carbonic anhydrase 0101
bromodomain adjacent to zinc finger domain 2B1001
Carbonic anhydrase0101
chromobox protein homolog 11001
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
ATP-binding cassette sub-family C member 30202
Multidrug resistance-associated protein 40203
Carbonic anhydrase0101
Carbonic anhydrase 120102
Bile salt export pump0202
Carbonic anhydrase 10103
Carbonic anhydrase 20215
Carbonic anhydrase 30101
5-hydroxytryptamine receptor 2C0101
5-hydroxytryptamine receptor 2A0101
Carbonic anhydrase 40203
Carbonic anhydrase 60102
Carbonic anhydrase 5A, mitochondrial0101
5-hydroxytryptamine receptor 2B0101
Delta-type opioid receptor0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase 70102
Carbonic anhydrase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Carbonic anhydrase 90102
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Delta carbonic anhydrase0101
Carbonic anhydrase 0101
Carbonic anhydrase 130101
Canalicular multispecific organic anion transporter 10202
Carbonic anhydrase 40101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
Carbonic anhydrase 140102
Carbonic anhydrase 5B, mitochondrial0102
Phosphodiesterase 0101
Multidrug resistance-associated protein 50001
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Luciferase1001
hypoxia-inducible factor 1 alpha subunit1001
progesterone receptor2002
estrogen-related nuclear receptor alpha3003
pregnane X nuclear receptor2002
estrogen nuclear receptor alpha4004
peroxisome proliferator activated receptor gamma1001
vitamin D (1,25- dihydroxyvitamin D3) receptor1001
Histone H2A.x1001
nuclear factor erythroid 2-related factor 2 isoform 12002
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
glp-1 receptor, partial1001
thioredoxin reductase1001
phosphopantetheinyl transferase2002
GLS protein1001
AR protein3003
regulator of G-protein signaling 42002
euchromatic histone-lysine N-methyltransferase 22002
beta-2 adrenergic receptor1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Glutamate receptor ionotropic, NMDA 2D0101
Excitatory amino acid transporter 40101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
Integrin beta-31113
Integrin alpha-IIb1113
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 21214
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, NMDA 1 0213
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, NMDA 2A 0213
Glutamate receptor ionotropic, NMDA 2B0314
Glutamate receptor ionotropic, NMDA 2C0213
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0001
Glutamate receptor ionotropic, NMDA 2D0213
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0213
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutamate receptor ionotropic, NMDA 3A0213
Chain A, Uracil Phosphoribosyltransferase0011
Chain B, Uracil Phosphoribosyltransferase0011
Chain C, Uracil Phosphoribosyltransferase0011
67.9K protein1001
2-dehydropantoate 2-reductase0011
Ras-related protein Rab-7a0011
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 90202
acetylcholinesterase1001
estrogen receptor 2 (ER beta)2002
retinoic acid nuclear receptor alpha variant 12002
thyroid stimulating hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
cellular tumor antigen p53 isoform a1001
Chain A, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)0101
Chain B, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)0101
Chain A, Histone deacetylase 7a0101
Chain A, Histone deacetylase 7a0101
Chain A, Ferritin light chain1001
Histone deacetylase 80202
ATAD5 protein, partial1001
PPM1D protein2002
Microtubule-associated protein tau1001
aldehyde dehydrogenase 1 family, member A11001
Histone deacetylase 0202
Lysine-specific demethylase 4E0202
glucocerebrosidase1001
unnamed protein product0001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
vitamin D3 receptor isoform VDRA1001
survival motor neuron protein isoform d1001
Histone deacetylase 10404
Histone deacetylase 304110
5-hydroxytryptamine receptor 3A0101
Histone deacetylase 30101
Interferon beta2002
Plasma kallikrein0101
Cytochrome P450 1A20101
Coagulation factor VII0101
Leukotriene A-4 hydrolase0202
Cytochrome P450 2D60202
Vitamin D3 receptor0101
Cytochrome P450 2C9 0202
Tissue factor0101
Adenosine receptor A10101
Cytochrome P450 2C190202
Delta-type opioid receptor0202
Histamine H2 receptor0202
Histone deacetylase 404212
Histone deacetylase 20101
Histone deacetylase 104413
Splicing factor 3B subunit 30101
Histone deacetylase 10202
Adenosine receptor A10101
Histone deacetylase 0202
Histone deacetylase 40101
Polyamine deacetylase HDAC100101
Histone deacetylase 30202
Histone deacetylase-like amidohydrolase0415
Histone deacetylase 70101
NAD-dependent protein deacetylase sirtuin-60112
Histone deacetylase 80101
Histone deacetylase 704211
Histone deacetylase 110101
Histone deacetylase 204312
HD2 type histone deacetylase HDA106 0404
Polyamine deacetylase HDAC1004110
Histone deacetylase 11 04110
Histone deacetylase 90101
Histone deacetylase 70202
Histone deacetylase 6 0202
Histone deacetylase 40202
Histone deacetylase 804211
Histone deacetylase 604312
Histone deacetylase 904110
Histone deacetylase 504110
Histone deacetylase 0202
Nuclear receptor corepressor 20404
Histone deacetylase 60202
Histone deacetylase 50101
Histone deacetylase 0202
Chain A, Histone deacetylase-like amidohydrolase0101
Chain A, Histone deacetylase-like amidohydrolase0101
Nrf21001
PAX80001
GLI family zinc finger 31001
Smad31001
caspase 7, apoptosis-related cysteine protease1001
nuclear receptor subfamily 1, group I, member 31001
EWS/FLI fusion protein1001
glucocorticoid receptor [Homo sapiens]1001
farnesoid X nuclear receptor1001
Gli10101
caspase-31001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
Caspase-71001
nuclear receptor subfamily 0 group B member 10101
cystic fibrosis transmembrane conductance regulator0101
caspase-31001
thyroid hormone receptor beta isoform 21001
histone deacetylase 9 isoform 31001
steroidogenic factor 10101
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
protein Wnt-3a precursor0101
urokinase plasminogen activator surface receptor precursor1001
geminin1001
peripheral myelin protein 221001
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Transient receptor potential cation channel subfamily V member 10101
Lysine-specific histone demethylase 1A0101
Tyrosine-protein kinase JAK20101
Bromodomain-containing protein 40101
Nuclear receptor corepressor 10202
Nuclear receptor subfamily 1 group I member 20011
Voltage-dependent calcium channel gamma-2 subunit1001
Tyrosine-protein kinase ABL10101
Epidermal growth factor receptor0101
Tubulin alpha-1A chain0101
Tubulin beta chain0101
Albumin0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Protein Tat0011
Cellular tumor antigen p531001
Amyloid-beta precursor protein0101
Heat shock protein HSP 90-alpha0101
Cytochrome P450 3A40102
Polyunsaturated fatty acid 5-lipoxygenase0001
Cytochrome P450 2C80101
Aminopeptidase N0101
Androgen receptor0101
Alpha-1B adrenergic receptor0101
Polyunsaturated fatty acid lipoxygenase ALOX150001
Polyunsaturated fatty acid lipoxygenase ALOX120001
5-hydroxytryptamine receptor 1A0101
Cannabinoid receptor 10101
Amine oxidase [flavin-containing] A0101
Alpha-1D adrenergic receptor0101
Leukotriene A-4 hydrolase0101
DNA (cytosine-5)-methyltransferase 10101
Amine oxidase [flavin-containing] B0101
Phosphatidylinositol 3-kinase regulatory subunit alpha0101
Proteasome subunit beta type-50101
Prostaglandin G/H synthase 20101
Vascular endothelial growth factor receptor 20101
Receptor-type tyrosine-protein kinase FLT30101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0101
Alpha-1A adrenergic receptor0101
Spike glycoprotein1001
E3 ubiquitin-protein ligase Mdm20101
Apoptosis regulator BAX 0011
Potassium voltage-gated channel subfamily H member 20101
Platelet-activating factor acetylhydrolase0101
Sigma non-opioid intracellular receptor 10101
Renin0101
Histone deacetylase 0101
Carboxypeptidase B20101
Histone-lysine N-methyltransferase EHMT20101
ATPase family AAA domain-containing protein 51001
Ataxin-21001
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
REST corepressor 30101
Nuclear receptor subfamily 1 group I member 20011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]