m 8218 has been researched along with Acute Lung Injury in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 5 (26.32) | 2.80 |
| Authors | Studies |
|---|---|
| Jing, G; Kong, Q; Ming, T; Song, X; Wu, X; Yuan, M | 1 |
| Chen, H; He, M; Li, S; Luo, A; Zhao, Y | 1 |
| Fang, D; Liu, H; Qi, Y; Sun, Y; Wei, G; Yang, F; Zhang, B | 1 |
| Chen, Q; Ma, Y; Wang, Q; Yang, X; Ye, S | 1 |
| Chen, J; Chen, M; Fang, D; Lin, Q; Wang, S; Weng, J | 1 |
| Chang, Y; Li, Y; Liu, Z; Yu, J; Yu, L | 1 |
| Leng, Y; Liu, HM; Meng, QT; Song, XM; Wang, EY; Wu, XJ; Xia, ZY; Zhan, LY; Zhao, B | 1 |
| Bai, T; Li, X; Sun, Y; Wang, S; Wang, W; Zhao, Y; Zhu, R | 1 |
| Duan, W; Kong, Q; Song, X; Wu, X; Xia, Z; Zhan, L | 1 |
| Cui, J; He, XH; Li, CS; Song, YG | 1 |
| Chen, K; Li, JJ; Wang, YL; Wang, YP; Xiao, F; Zhan, J; Zhang, ZZ | 1 |
| Chen, Y; Liu, L; Mo, LQ; Mou, M; Ren, CH; Wu, GM; Zhou, J | 1 |
| Chen, KZ; Huang, Y; Li, J; Pan, JH; Zhang, L | 1 |
| Gan, J; Jiang, G; Shen, W; Wu, H; Xu, S | 1 |
| Huang, Y; Li, Z; Liu, J; Luo, N; Wang, S | 1 |
| Wang, LL; Wu, XJ; Xia, ZY; Zhan, LY | 1 |
| Chen, C; Chen, K; Liu, Y; Wang, Y; Zhan, J; Zhang, Z | 1 |
| Li, BQ; Liu, HM; Nie, SN; Qian, XM; Shao, DB; Sun, HC | 1 |
| Jian, XD; Lin, DW; Liu, F; Liu, J; Ning, Q; Zhang, ZC; Zhao, B | 1 |
1 trial(s) available for m 8218 and Acute Lung Injury
| Article | Year |
|---|---|
Effect of penehyclidine hydrochloride on patients with acute lung injury and its mechanisms.
Topics: Acute Lung Injury; Cytokines; Heart Rate; Humans; Oxygen; Prognosis; Quinuclidines; Toll-Like Receptor 4 | 2010 |
18 other study(ies) available for m 8218 and Acute Lung Injury
| Article | Year |
|---|---|
Tumor necrosis factor α‑induced protein 8‑like 2 contributes to penehyclidine hydrochloride pretreatment against lipopolysaccharide‑induced acute lung injury in a mouse model.
Topics: Acute Lung Injury; Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Lung; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-kappa B; Quinuclidines; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2021 |
Effect of penehyclidine hydrochloride on inflammatory response and oxidative stress in rats with cardiopulmonary bypass related-lung injury.
Topics: Acute Lung Injury; Animals; Cardiopulmonary Bypass; Lung; Oxidative Stress; Quinuclidines; Rats; Rats, Sprague-Dawley; Water | 2022 |
[Penehyclidine hydrochloride regulates angiopoietin 2/vascular endothelial cadherin (Ang2/VE-cadherin) pathway to alleviate LPS induced lung injury in rats].
Topics: Acute Lung Injury; Angiopoietin-2; Animals; Interleukin-6; Lipopolysaccharides; Lung; Male; Mice; Rats; Rats, Sprague-Dawley; Sepsis; Tumor Necrosis Factor-alpha | 2023 |
Penehyclidine Hydrochloride Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Ameliorating Apoptosis and Endoplasmic Reticulum Stress.
Topics: Acute Lung Injury; Animals; Apoptosis; Drug Evaluation, Preclinical; Endoplasmic Reticulum Stress; Glutathione Peroxidase; Lipopolysaccharides; Lung; Male; Malondialdehyde; Peroxidase; Quinuclidines; Random Allocation; Rats, Sprague-Dawley; Superoxide Dismutase | 2020 |
Penehyclidine hydrochloride defends against LPS-induced ALI in rats by mitigating endoplasmic reticulum stress and promoting the Hes1/Notch1 pathway.
Topics: Acute Lung Injury; Animals; Apoptosis; Dose-Response Relationship, Drug; Down-Regulation; Endoplasmic Reticulum Stress; Hyaluronan Synthases; Lipopolysaccharides; Macrophages, Alveolar; Male; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Notch1; Signal Transduction | 2019 |
Penehyclidine hydrochloride inhibits renal ischemia/reperfusion-induced acute lung injury by activating the Nrf2 pathway.
Topics: Acute Lung Injury; Animals; Apoptosis; Disease Models, Animal; Gene Knockout Techniques; Humans; Kidney; Kidney Diseases; Lung; Macrophages, Alveolar; Male; NF-E2-Related Factor 2; Oxidative Stress; Quassins; Quinuclidines; Rats; Rats, Transgenic; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; tert-Butylhydroperoxide | 2020 |
Penehyclidine hydrochloride inhibits TLR4 signaling and inflammation, and attenuates blunt chest trauma and hemorrhagic shock-induced acute lung injury in rats.
Topics: Acute Lung Injury; Animals; Inflammation; Male; MAP Kinase Signaling System; Quinuclidines; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Thorax; Toll-Like Receptor 4; Wounds, Nonpenetrating | 2018 |
Effects of penehyclidine hydrochloride on severe acute pancreatitis-associated acute lung injury in rats.
Topics: Acute Disease; Acute Lung Injury; Animals; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-1beta; Interleukin-6; Lung; Male; Pancreas; Pancreatitis; Quinuclidines; Rats, Sprague-Dawley; Toll-Like Receptor 4; Transcription Factor RelA | 2018 |
Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute lung injury in rats: Potential role of caveolin‑1 expression upregulation.
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Capillary Permeability; Caveolin 1; Cell Line; Cytokines; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Mice; Peroxidase; Pneumonia; Quinuclidines; Rats, Sprague-Dawley; Up-Regulation | 2019 |
Protective effects of penehyclidine hydrochloride on acute lung injury caused by severe dichlorvos poisoning in swine.
Topics: Acute Lung Injury; Animals; Dichlorvos; Female; Quinuclidines; Swine | 2013 |
Penehyclidine hydrochloride decreases pulmonary microvascular permeability by upregulating beta arrestins in a murine cecal ligation and puncture model.
Topics: Acute Lung Injury; Animals; Arrestins; beta-Arrestins; Capillary Permeability; Cecum; Cholinergic Antagonists; Disease Models, Animal; Female; Ligation; Lung; Mice, Inbred Strains; Microcirculation; NF-kappa B; Pulmonary Circulation; Quinuclidines; Random Allocation; Up-Regulation; Wounds, Stab | 2015 |
Penehyclidine hydrochloride postconditioning on lipopolysaccharide-induced acute lung injury by inhibition of inflammatory factors in a rodent model.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Interleukin-6; Lipopolysaccharides; Lung; Male; NF-kappa B; Peroxidase; Pulmonary Gas Exchange; Quinuclidines; Rats, Sprague-Dawley; Sepsis; Tumor Necrosis Factor-alpha | 2015 |
Penehyclidine prevents nuclear factor-kappaB activation in acute lung injury induced by lipopolysaccharide.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; DNA; Gene Expression Regulation; Interleukin-1beta; L-Lactate Dehydrogenase; Lipopolysaccharides; Lung; Male; Neutrophils; NF-kappa B; Peroxidase; Quinuclidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha | 2008 |
Penehyclidine hydrochloride attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway.
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Cholinergic Antagonists; Extracellular Signal-Regulated MAP Kinases; L-Lactate Dehydrogenase; Lipopolysaccharides; Lung; Male; Malondialdehyde; MAP Kinase Signaling System; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Peroxidase; Quinuclidines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2009 |
[Effect of penehyclidine hydrochloride on oleic acid-acute lung injury in canine during ventilation].
Topics: Acute Lung Injury; Animals; Dogs; Male; Oleic Acid; Quinuclidines; Respiration, Artificial; Respiratory Distress Syndrome | 2009 |
Effects of penehyclidine hydrochloride on apoptosis of lung tissues in rats with traumatic acute lung injury.
Topics: Acute Lung Injury; Animals; Apoptosis; bcl-2-Associated X Protein; Lung; Male; Proto-Oncogene Proteins c-bcl-2; Quinuclidines; Rats; Rats, Sprague-Dawley; Thoracic Injuries; Wounds, Nonpenetrating | 2010 |
Effect of penehyclidine hydrochloride on expressions of MAPK in mice with CLP-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Capillary Permeability; Cecum; Extracellular Signal-Regulated MAP Kinases; Female; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Ligation; Lung; Mice; Microvessels; Mitogen-Activated Protein Kinases; Oxygen; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phosphorylation; Punctures; Quinuclidines | 2011 |
[Experimental therapy of penehyclidine hydrochloride on paraquat-induced acute lung injury].
Topics: Acute Lung Injury; Animals; Caveolin 1; Endothelins; Hydroxyproline; Male; Matrix Metalloproteinase 2; Paraquat; Quinuclidines; Rats; Rats, Wistar | 2010 |