m 8218 has been researched along with mocetinostat in 7 studies
| Studies (m 8218) | Trials (m 8218) | Recent Studies (post-2010) (m 8218) | Studies (mocetinostat) | Trials (mocetinostat) | Recent Studies (post-2010) (mocetinostat) |
|---|---|---|---|---|---|
| 118 | 24 | 80 | 21,735 | 390 | 8,606 |
| Protein | Taxonomy | m 8218 (IC50) | mocetinostat (IC50) |
|---|---|---|---|
| Histone deacetylase 3 | Homo sapiens (human) | 0.7851 | |
| Nuclear receptor corepressor 1 | Homo sapiens (human) | 0.022 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.57 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.102 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.102 | |
| Histone deacetylase 4 | Homo sapiens (human) | 0.5717 | |
| Histone deacetylase 1 | Homo sapiens (human) | 0.3433 | |
| Histone deacetylase 7 | Homo sapiens (human) | 0.6725 | |
| Histone deacetylase 2 | Homo sapiens (human) | 0.3537 | |
| Histone deacetylase 11 | Homo sapiens (human) | 0.6386 | |
| Histone deacetylase 8 | Homo sapiens (human) | 0.6725 | |
| Histone deacetylase 6 | Homo sapiens (human) | 0.5717 | |
| Histone deacetylase 5 | Homo sapiens (human) | 0.6725 | |
| Nuclear receptor corepressor 2 | Homo sapiens (human) | 0.045 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, KZ; Huang, Y; Li, J; Pan, JH; Zhang, L | 1 |
| Gan, J; Jiang, G; Shen, W; Wu, H; Xu, S | 1 |
| Chen, C; Chen, K; Liu, Y; Wang, Y; Zhan, J; Zhang, Z | 1 |
| Luo, T; Meng, QT; Song, XM; Wang, LL; Wu, XJ; Xia, ZY; Zhan, LY | 1 |
| Chen, Y; Liu, L; Mo, LQ; Mou, M; Ren, CH; Wu, GM; Zhou, J | 1 |
| Duan, W; Kong, Q; Song, X; Wu, X; Xia, Z; Zhan, L | 1 |
| Chen, Q; Ma, Y; Wang, Q; Yang, X; Ye, S | 1 |
7 other study(ies) available for m 8218 and mocetinostat
| Article | Year |
|---|---|
Penehyclidine prevents nuclear factor-kappaB activation in acute lung injury induced by lipopolysaccharide.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; DNA; Gene Expression Regulation; Interleukin-1beta; L-Lactate Dehydrogenase; Lipopolysaccharides; Lung; Male; Neutrophils; NF-kappa B; Peroxidase; Quinuclidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha | 2008 |
Penehyclidine hydrochloride attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway.
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Cholinergic Antagonists; Extracellular Signal-Regulated MAP Kinases; L-Lactate Dehydrogenase; Lipopolysaccharides; Lung; Male; Malondialdehyde; MAP Kinase Signaling System; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Peroxidase; Quinuclidines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2009 |
Effect of penehyclidine hydrochloride on expressions of MAPK in mice with CLP-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Capillary Permeability; Cecum; Extracellular Signal-Regulated MAP Kinases; Female; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Ligation; Lung; Mice; Microvessels; Mitogen-Activated Protein Kinases; Oxygen; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phosphorylation; Punctures; Quinuclidines | 2011 |
Effects of penehyclidine hydrochloride on pulmonary contusion from blunt chest trauma in rats.
Topics: Animals; Anti-Inflammatory Agents; Contusions; Enzyme-Linked Immunosorbent Assay; Immunity, Innate; Immunohistochemistry; Interleukin-6; Lung Injury; Male; Peroxidase; Protective Agents; Quinuclidines; Random Allocation; Rats; Rats, Sprague-Dawley; Thoracic Injuries; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Wounds, Nonpenetrating | 2012 |
Penehyclidine hydrochloride postconditioning on lipopolysaccharide-induced acute lung injury by inhibition of inflammatory factors in a rodent model.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Interleukin-6; Lipopolysaccharides; Lung; Male; NF-kappa B; Peroxidase; Pulmonary Gas Exchange; Quinuclidines; Rats, Sprague-Dawley; Sepsis; Tumor Necrosis Factor-alpha | 2015 |
Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute lung injury in rats: Potential role of caveolin‑1 expression upregulation.
Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Capillary Permeability; Caveolin 1; Cell Line; Cytokines; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Mice; Peroxidase; Pneumonia; Quinuclidines; Rats, Sprague-Dawley; Up-Regulation | 2019 |
Penehyclidine Hydrochloride Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Ameliorating Apoptosis and Endoplasmic Reticulum Stress.
Topics: Acute Lung Injury; Animals; Apoptosis; Drug Evaluation, Preclinical; Endoplasmic Reticulum Stress; Glutathione Peroxidase; Lipopolysaccharides; Lung; Male; Malondialdehyde; Peroxidase; Quinuclidines; Random Allocation; Rats, Sprague-Dawley; Superoxide Dismutase | 2020 |