| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
methanol
Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group. | 2.25 | 1 | 0 | alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound | amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite |
tacrine
Tacrine: A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.. tacrine : A member of the class of acridines that is 1,2,3,4-tetrahydroacridine substituted by an amino group at position 9. It is used in the treatment of Alzheimer's disease. | 2.03 | 1 | 0 | acridines;
aromatic amine | EC 3.1.1.7 (acetylcholinesterase) inhibitor |
berberine
[no description available] | 2.04 | 1 | 0 | alkaloid antibiotic;
berberine alkaloid;
botanical anti-fungal agent;
organic heteropentacyclic compound | antilipemic drug;
antineoplastic agent;
antioxidant;
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor;
EC 1.21.3.3 (reticuline oxidase) inhibitor;
EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
hypoglycemic agent;
metabolite;
potassium channel blocker |
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. | 1.98 | 1 | 0 | aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug |
mefloquine hydrochloride
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4. | 1.98 | 1 | 0 | organofluorine compound;
piperidines;
quinolines;
secondary alcohol | |
catechin
Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite. | 2.15 | 1 | 0 | catechin | antioxidant;
plant metabolite |
galantamine
Galantamine: A benzazepine derived from norbelladine. It is found in GALANTHUS and other AMARYLLIDACEAE. It is a cholinesterase inhibitor that has been used to reverse the muscular effects of GALLAMINE TRIETHIODIDE and TUBOCURARINE and has been studied as a treatment for ALZHEIMER DISEASE and other central nervous system disorders.. galanthamine : A benzazepine alkaloid isolated from certain species of daffodils. | 2.03 | 1 | 0 | benzazepine alkaloid fundamental parent;
benzazepine alkaloid;
organic heterotetracyclic compound;
tertiary amino compound | antidote to curare poisoning;
cholinergic drug;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant metabolite |
isocorydine
isocorydine: from root tubers of Stephania Kwangsiensis H.S. Lo; RN given refers to (+-)-isomer; structure in Merck Index, 9th ed, #5017 | 2.15 | 1 | 0 | aporphine alkaloid | |
corydine
corydine: structure given in first source; RN given refers to (S)-isomer | 1.98 | 1 | 0 | | |
palmatine
burasaine: structure in first source | 2.15 | 1 | 0 | berberine alkaloid;
organic heterotetracyclic compound | plant metabolite |
lirinidine
lirinidine: from Nelumbro nucifera; RN given refers to (S)-isomer | 2.25 | 1 | 0 | | |
tetrahydropalmatine
[no description available] | 1.98 | 1 | 0 | an (S)-7,8,13,14-tetrahydroprotoberberine;
berberine alkaloid;
organic heterotetracyclic compound | adrenergic agent;
dopaminergic antagonist;
non-narcotic analgesic |
magnoflorine
magnoflorine: opium alkaloid having the aporphine configuration; RN given refers to parent cpd(S)-isomer; structure. (S)-magnoflorine : An aporphine alkaloid that is (S)-corytuberine in which the nitrogen has been quaternised by an additional methyl group. | 1.98 | 1 | 0 | aporphine alkaloid;
quaternary ammonium ion | plant metabolite |
stepharine
stepharine: RN given refers to (R)-isomer. stepharine : An isoquinoline alkaloid with formula C18H19NO3 that is isolated from several species of Stephania. | 2.15 | 1 | 0 | | |
aporphine
aporphine: RN given refers to parent cpd without isomeric designation. aporphine : An isoquinoline alkaloid that is the N-methyl derivative of 5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline. | 2.15 | 1 | 0 | aporphine alkaloid;
isoquinoline alkaloid fundamental parent;
tertiary amino compound | |
roemerine
roemerine: from root tubers of Stephania kwangsiensis H.S. Lo; RN given refers to (R)-isomer; synonym aporeine refers to (S)-isomer; structure in Merck Index, 9th ed, #779 | 2.15 | 1 | 0 | isoquinoline alkaloid | |
xylopine
xylopine: RN given refers to (R)-isomer; RN for cpd without isomeric designation not available 3/90; structure given in first source | 1.98 | 1 | 0 | aporphine alkaloid | |
anonaine
anonaine: smooth muscle relaxant; aporphine alkaloid isolated from roots of Annona cherimolia; structure in first source. (-)-annonaine : An aporphine alkaloid that exhibits anti-cancer, trypanocidal and antiplasmodial activites. | 2.43 | 2 | 0 | aporphine alkaloid;
organic heteropentacyclic compound;
oxacycle | antineoplastic agent;
antiplasmodial drug;
trypanocidal drug |
corydalmine
corydalmine: antagonizes dopamine receptors; structure given in first source; RN given refers to (S)-isomer | 1.98 | 1 | 0 | | |
nantenine
nantenine: from Nandina domestica Thundberg; RN given refers to (S)-isomer; structure given in first source | 2.15 | 1 | 0 | oxoaporphine alkaloid | metabolite |
pronuciferine
pronuciferine: alkaloid; structure in first source. (+)-pronuciferine : An isoquinoline alkaloid isolated from Berberis coletioides. | 2.25 | 1 | 0 | aromatic ether;
cyclic ketone;
isoquinoline alkaloid;
isoquinolines;
organic heterotetracyclic compound | plant metabolite |
taspine
taspine: RN given refers to parent cpd; structure | 2.03 | 1 | 0 | | |
norcoralydine
norcoralydine: neuromuscular blocking agent; RN given refers to (S)-isomer; structure | 1.98 | 1 | 0 | alkaloid | |
dicentrine
[no description available] | 1.98 | 1 | 0 | | |
reticuline
reticuline: opium alkaloid; dopamine receptor blocker; RN given refers to (S)-isomer; structure. (S)-reticuline : The (S)-enantiomer of reticuline. | 2.41 | 2 | 0 | reticuline | EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor |
n-methylactinodaphnine
N-methylactinodaphnine: isolated from Illigera luzonensis; structure given in first source | 1.98 | 1 | 0 | aporphine alkaloid | |
tetrahydropalmatine
[no description available] | 2.15 | 1 | 0 | | |
quinine
[no description available] | 1.98 | 1 | 0 | cinchona alkaloid | antimalarial;
muscle relaxant;
non-narcotic analgesic |
stepholidine
stepholidine: protoberberine alkaloid isolated from opium; dual D1 receptor agonist and D2 receptor antagonist | 2.04 | 1 | 0 | | |
acutumine
acutumine: dechloroacutumine is the dechloro derivative of acutumine | 2.04 | 1 | 0 | alkaloid | |