biie-0246 and Cognitive-Dysfunction

Though patients with diabetes mellitus are reported to show deficits in social interaction, the mechanisms of these impairments are unclear. The present study investigated the role of AMPA and neuropeptide Y (NPY) receptors in the ventral hippocampus (vHC) and basolateral amygdala (BLA) in the social behavior of diabetic mice. In the three-chamber test, streptozotocin (STZ)-induced diabetic mice showed impairment in social novelty preference, but not in sociability. Injection of the AMPA receptor antagonist NBQX into vHC or BLA each restored social novelty preference in STZ-induced diabetic mice. NPY content in amygdala, but not in vHC, of STZ-induced diabetic mice was increased relative to non-diabetic mice. In STZ-induced diabetic mice, injection of the NPY Y

Topics: Animals; Arginine; Basolateral Nuclear Complex; Behavior, Animal; Benzazepines; Cognitive Dysfunction; Diabetes Complications; Diabetes Mellitus, Experimental; Excitatory Amino Acid Antagonists; Hippocampus; Male; Mice; Mice, Inbred ICR; Neuropeptide Y; Receptors, AMPA; Receptors, Neuropeptide Y; Social Behavior