| Assay ID | Title | Year | Journal | Article |
|---|
| AID746111 | Biodistribution in CD1 mouse adrenal at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746120 | Biodistribution in CD1 mouse small intestine at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID580948 | Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as evoked ACh-induced current by voltage clamp method | 2010 | ACS medicinal chemistry letters, Nov-11, Volume: 1, Issue:8
| Exploring α7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB. |
| AID746115 | Biodistribution in CD1 mouse bladder at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746080 | Biodistribution in CD1 mouse liver at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746081 | Biodistribution in CD1 mouse small intestine at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746113 | Biodistribution in CD1 mouse thymus at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746100 | Biodistribution in CD1 mouse large intestine at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746122 | Biodistribution in CD1 mouse lung at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746156 | Biodistribution in CD1 mouse liver at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746162 | Biodistribution in CD1 mouse heart at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746088 | Plasma concentration in CD1 mouse at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746091 | Biodistribution in CD1 mouse skin at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746089 | Biodistribution in CD1 mouse muscle at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746116 | Biodistribution in CD1 mouse urine at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746135 | Biodistribution in CD1 mouse kidney at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746123 | Biodistribution in CD1 mouse heart at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431142 | Displacement of L-[3H]Nicotine from alpha4beta2 nAChR in rat brain homogenate by rapid filtration method | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID431141 | Agonist activity at rat alpha7 nAChR expressed in Xenopus oocytes at 32 uM by two-electrode voltage clamp technique relative to nicotine | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID746138 | Biodistribution in CD1 mouse large intestine at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746073 | Biodistribution in CD1 mouse thymus at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID690414 | Binding affinity to human alpha7 nAchR | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID746097 | Biodistribution in CD1 mouse urine at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746074 | Biodistribution in CD1 mouse pancreas at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746104 | Biodistribution in CD1 mouse heart at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746119 | Biodistribution in CD1 mouse large intestine at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID1460122 | In vivo agonist activity at alpha7 nAChR in Wistar rat assessed as induction of c-fos gene expression in medial prefrontal cortex at 10 mg/kg, sc after 2 hrs by qPCR method relative to control | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3
| Development of spiroguanidine-derived α7 neuronal nicotinic receptor partial agonists. |
| AID746147 | Biodistribution in CD1 mouse femur at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746076 | Biodistribution in CD1 mouse bladder at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746114 | Biodistribution in CD1 mouse spleen at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746127 | Biodistribution in CD1 mouse femur at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746132 | Biodistribution in CD1 mouse thymus at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746105 | Biodistribution in CD1 mouse brain at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431153 | Drug concentration in Sprague-Dawley rat CSF at 5 mg/kg, sc after 1 hr | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID1336491 | Reversal of MK-801 induced cognitive deficits in Sprague-Dawley rat assessed as reduction in number of trials to reach set shift at 10 mg/kg, po administered immediately prior to MK-801 | | | |
| AID690429 | Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocytes relative to acetylcholine | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID746077 | Biodistribution in CD1 mouse urine at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746106 | Plasma concentration in CD1 mouse at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746163 | Plasma concentration in CD1 mouse at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431140 | Displacement of [125I]BTX from rat alpha7 nAChR expressed in rat GH4C1 cells | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID746072 | Biodistribution in CD1 mouse adrenal at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746144 | Plasma concentration in CD1 mouse at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746131 | Biodistribution in CD1 mouse pancreas at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746164 | Biodistribution in CD1 mouse blood at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746099 | Biodistribution in CD1 mouse liver at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746140 | Biodistribution in CD1 mouse stomach at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746107 | Biodistribution in CD1 mouse blood at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID1460128 | Effect on beta2-microglobulin gene expression in Wistar rat medial prefrontal cortex at 10 mg/kg, sc after 2 hrs by qPCR method | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3
| Development of spiroguanidine-derived α7 neuronal nicotinic receptor partial agonists. |
| AID746130 | Biodistribution in CD1 mouse adrenal at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID675874 | Partial agonist activity at human alpha7 nAChR expressed in Xenopus oocyte assessed as stimulation of ACh-induced current after 30 secs by electrophysiological assay | 2012 | Journal of medicinal chemistry, May-24, Volume: 55, Issue:10
| Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711). |
| AID746041 | Displacement of [3H]alpha-BTX from human alpha7 nAChR expressed in rat GH4C1 cells after 60 mins | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746141 | Biodistribution in CD1 mouse lung at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746133 | Biodistribution in CD1 mouse spleen at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746137 | Biodistribution in CD1 mouse liver at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746134 | Biodistribution in CD1 mouse bladder at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746136 | Biodistribution in CD1 mouse urine at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746158 | Biodistribution in CD1 mouse stomach at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746148 | Biodistribution in CD1 mouse skin at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746090 | Biodistribution in CD1 mouse femur at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431147 | Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells at 10 uM | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID746117 | Biodistribution in CD1 mouse kidney at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID580944 | Binding affinity to human alpha7 nAChR | 2010 | ACS medicinal chemistry letters, Nov-11, Volume: 1, Issue:8
| Exploring α7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB. |
| AID690426 | Binding affinity to rat alpha7 nAchR | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID746151 | Biodistribution in CD1 mouse spleen at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746071 | Biodistribution in CD1 mouse skin at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746161 | Biodistribution in CD1 mouse brain at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746149 | Biodistribution in CD1 mouse adrenal at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746160 | Biodistribution in CD1 mouse lung at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746109 | Biodistribution in CD1 mouse skin at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746126 | Plasma concentration in CD1 mouse at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746129 | Biodistribution in CD1 mouse skin at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746159 | Biodistribution in CD1 mouse small intestine at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746082 | Biodistribution in CD1 mouse stomach at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID690430 | Partial agonist activity at human alpha7 nAChR expressed in GH4C1 cells relative to acetylcholine | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID746152 | Biodistribution in CD1 mouse thymus at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746095 | Biodistribution in CD1 mouse bladder at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746153 | Biodistribution in CD1 mouse bladder at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID690427 | Intrinsic activity at human alpha7 nAChR expressed in Xenopus oocytes relative to acetylcholine | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID746142 | Biodistribution in CD1 mouse heart at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431151 | Plasma concentration in Sprague-Dawley rat at 5 mg/kg, sc after 1 hr | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID1460126 | In vivo agonist activity at alpha7 nAChR in Wistar rat assessed as induction of Arc gene expression in medial prefrontal cortex at 10 mg/kg, sc after 2 hrs by qPCR method relative to control | 2017 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 27, Issue:3
| Development of spiroguanidine-derived α7 neuronal nicotinic receptor partial agonists. |
| AID690428 | Intrinsic activity at human alpha7 nAChR expressed in GH4C1 cells relative to acetylcholine | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID746154 | Biodistribution in CD1 mouse kidney at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431148 | Displacement of [3H]LY278584 from human 5HT3 receptor expressed in HEK293 cells | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID746143 | Biodistribution in CD1 mouse brain at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431144 | Displacement of [3H]epibatidine from alpha3 nAChR in human IMR32 cells | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID746085 | Biodistribution in CD1 mouse brain at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431146 | Aqueous solubility of the compound | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID746118 | Biodistribution in CD1 mouse liver at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746096 | Biodistribution in CD1 mouse spleen at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746108 | Biodistribution in CD1 mouse femur at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID1278549 | Displacement of [3H]methyllycaconitine from Sprague-Dawley rat brain alpha7* nAChR incubated for 2.5 hrs by liquid scintillation counting analysis | 2016 | European journal of medicinal chemistry, Mar-03, Volume: 110 | New quinoline derivatives as nicotinic receptor modulators. |
| AID746121 | Biodistribution in CD1 mouse stomach at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746157 | Biodistribution in CD1 mouse large intestine at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746079 | Biodistribution in CD1 mouse large intestine at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746083 | Biodistribution in CD1 mouse lung at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746070 | Biodistribution in CD1 mouse femur at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746124 | Biodistribution in CD1 mouse brain at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746103 | Biodistribution in CD1 mouse lung at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746139 | Biodistribution in CD1 mouse small intestine at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746110 | Biodistribution in CD1 mouse muscle at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746075 | Biodistribution in CD1 mouse spleen at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746146 | Biodistribution in CD1 mouse muscle at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746093 | Biodistribution in CD1 mouse adrenal at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746128 | Biodistribution in CD1 mouse muscle at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746101 | Biodistribution in CD1 mouse stomach at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746094 | Biodistribution in CD1 mouse thymus at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746112 | Biodistribution in CD1 mouse pancreas at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746069 | Biodistribution in CD1 mouse muscle at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431149 | Intrinsic clearance in human liver microsomes at 1 uM at pH 7.4 after 30 mins | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID746098 | Biodistribution in CD1 mouse kidney at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746155 | Biodistribution in CD1 mouse urine at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746150 | Biodistribution in CD1 mouse pancreas at 200 to 300 kBq, iv measured at 5 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431150 | Drug concentration in Sprague-Dawley rat brain at 5 mg/kg, sc after 1 hr | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID746087 | Biodistribution in CD1 mouse blood at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431145 | Octanol-aqueous buffer partition coefficient, log D at pH 7.4 | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID746092 | Biodistribution in CD1 mouse pancreas at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746078 | Biodistribution in CD1 mouse kidney at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431143 | Selectivity ratio of IC50 for alpha4beta2 nAChR in rat brain homogenate to Ki for rat alpha7 nAChR | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID746084 | Biodistribution in CD1 mouse heart at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis in presence of SSR180711 | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID431152 | Ratio of drug level in brain to plasma in Sprague-Dawley rat at 5 mg/kg, sc after 1 hr | 2009 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
| Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. |
| AID746102 | Biodistribution in CD1 mouse small intestine at 200 to 300 kBq, iv measured at 60 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID746145 | Biodistribution in CD1 mouse blood at 200 to 300 kBq, iv measured at 15 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| AID690279 | Binding affinity to human 5HT3 receptor at 10 uM by radioligand binding assay | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID746125 | Biodistribution in CD1 mouse blood at 200 to 300 kBq, iv measured at 30 mins by gamma counting analysis | 2013 | Bioorganic & medicinal chemistry, May-01, Volume: 21, Issue:9
| Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging of α7 nicotinic acetylcholine receptors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |