| Assay ID | Title | Year | Journal | Article |
|---|
| AID1609179 | Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of channel current at -90 mV holding potential by two-electrode voltage clamp method | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of fused heterocyclic carboxamide derivatives as novel α7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. |
| AID709627 | Displacement of [3H]epibatidine form human alpha7 nAchR expressed in HEK293 cells | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. |
| AID709449 | Inhibition of human 5HT3R at 10 nM | 2012 | Journal of medicinal chemistry, Nov-26, Volume: 55, Issue:22
| Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. |
| AID1292022 | Binding affinity to human alpha7 nAChR expressed in xenopus oocytes preincubated for 10 mins followed by acetylcholine addition by patch clamp electrophysiological assay relative to acetylcholine | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists. |
| AID1584935 | Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes by voltage clamp electrophysiological method | 2018 | European journal of medicinal chemistry, Dec-05, Volume: 160 | Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities. |
| AID1609178 | Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of channel current at 10 uM at -90 mV holding potential by two-electrode voltage clamp method relative to acetylcholine | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of fused heterocyclic carboxamide derivatives as novel α7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. |
| AID690408 | Binding affinity to 5HT3 receptor | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID1609177 | Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of channel current at 100 uM at -90 mV holding potential by two-electrode voltage clamp method relative to acetylcholine | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of fused heterocyclic carboxamide derivatives as novel α7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. |
| AID1292021 | Agonist activity at human alpha7 nAChR expressed in xenopus oocytes preincubated for 10 mins followed by acetylcholine addition by patch clamp electrophysiological assay | 2016 | European journal of medicinal chemistry, Jun-10, Volume: 115 | Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists. |
| AID690414 | Binding affinity to human alpha7 nAchR | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID1609180 | Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as peak current amplitude at -90 mV holding potential by two-electrode voltage clamp method relative to acetylcholine | 2019 | European journal of medicinal chemistry, Nov-15, Volume: 182 | Discovery of fused heterocyclic carboxamide derivatives as novel α7-nAChR agonists: Synthesis, preliminary SAR and biological evaluation. |
| AID1278549 | Displacement of [3H]methyllycaconitine from Sprague-Dawley rat brain alpha7* nAChR incubated for 2.5 hrs by liquid scintillation counting analysis | 2016 | European journal of medicinal chemistry, Mar-03, Volume: 110 | New quinoline derivatives as nicotinic receptor modulators. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346583 | Human nicotinic acetylcholine receptor alpha7 subunit (Nicotinic acetylcholine receptors) | 2011 | Journal of medicinal chemistry, Dec-08, Volume: 54, Issue:23
| Discovery and development of α7 nicotinic acetylcholine receptor modulators. |
| AID1346583 | Human nicotinic acetylcholine receptor alpha7 subunit (Nicotinic acetylcholine receptors) | 2004 | Drugs in R&D, , Volume: 5, Issue:2
| Natalizumab: AN 100226, anti-4alpha integrin monoclonal antibody. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |