Compounds > 2,4-diamino-6-nitrotoluene
Page last updated: 2024-12-07

2,4-diamino-6-nitrotoluene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2,4-diamino-6-nitrotoluene: urinary metabolite of 2,4,6-TNT; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2,4-diamino-6-nitrotoluene : A member of the class of amino-nitrotoluenes that is 2,4-diaminotoluene bearing a nitro substituent at position 6. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID96177
CHEBI ID19342
SCHEMBL ID629679
MeSH IDM0134365

Synonyms (33)

Synonym
toluene-2,4-diamine, 6-nitro-
4-methyl-5-nitro-benzene-1,3-diamine
2,4-diamino-1-methyl-6-nitrobenzene
2,4-diamino-6-nitrotoluene
nsc58161
nsc58082
2-nitro-4,6-diaminotoluene
6629-29-4
nsc-58082
nsc-58161
1, 4-methyl-5-nitro-
1,3-benzenediamine, 4-methyl-5-nitro-
ai3-23209
ccris 5189
nsc 58082
nsc 58161
AC-10513
4-methyl-5-nitrobenzene-1,3-diamine
AKOS004121742
dqj5ex5kmd ,
unii-dqj5ex5kmd
FT-0609971
SCHEMBL629679
4-methyl-5-nitro-1,3-benzenediamine #
DFZSBQYOXAUYCB-UHFFFAOYSA-N
CHEBI:19342
DS-2960
DTXSID10216498
Q27109172
4-methyl-5-nitro-1,3-benzenediamine
A867495
4-methyl-5-nitro-1,3-benzenediamine; 2,4-diamino-6-nitrotoluene; 2-nitro-4,6-diaminotoluene; nsc 58082; nsc 58161
CS-0153544

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" alterations in this endpoint may result in adverse effects on the organism and could be used as an early indicator of toxicity."( Toxicity of sediment-associated nitroaromatic and cyclonitramine compounds to benthic invertebrates.
Bridges, TS; Farrar, JD; Inouye, LS; Lotufo, GR; Ringelberg, DB, 2001)		0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
xenobiotic metaboliteAny metabolite produced by metabolism of a xenobiotic compound.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
amino-nitrotolueneA nitrotoluene carrying at least one amino group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's4 (44.44)18.2507
2000's4 (44.44)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.26

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.26 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.82 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.26)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
sym-trinitrobenzene
Trinitrobenzenes: Benzene derivatives which are substituted with three nitro groups in any position.. 1,3,5-trinitrobenzene : A trinitrobenzene in which each of the nitro groups is meta- to the other two.		210trinitrobenzeneexplosive
trinitrotoluene
Trinitrotoluene: A 2,4,6-trinitrotoluene, which is an explosive chemical that can cause skin irritation and other toxic consequences.. 2,4,6-trinitrotoluene : A trinitrotoluene having the nitro groups at positions 2, 4 and 6.		8.3870trinitrotolueneexplosive
cyclonite
cyclonite: explosive & convulsant; structure. 1,3,5-trinitro-1,3,5-triazinane : An N-nitro compound that is 1,3,5-triazinane in which all three of the hydrogens attached to the nitrogens have been replaced by nitro groups. It is widely used in both industrial and military explosives.		2101,3,5-triazinanes;
N-nitro compound		explosive
octogen
octogen: an explosive compound, contaminant in waste water; structure given in third source. octogen : A tetrazocane that is 1,3,5,7-tetrazocane in which the hydrogen atom attached to each of the nitrogens is replaced by a nitro group.		210N-nitro compound;
tetrazocane		explosive
4-amino-2,6-dinitrotoluene
4-amino-2,6-dinitrotoluene : An amino-nitrotoluene that is 2,6-dinitrotoluene substituted at position 4 by an amino group.		2.6930amino-nitrotolueneexplosive;
fungal xenobiotic metabolite;
marine metabolite
2-amino-4,6-dinitrotoluene
2-amino-4,6-dinitrotoluene : An amino-nitrotoluene that is 4,6-dinitrotoluene substituted at position 2 by an amino group.		2.9240amino-nitrotolueneexplosive;
fungal xenobiotic metabolite
dinitrobenzenes
Dinitrobenzenes: Benzene derivatives which are substituted with two nitro groups in the ortho, meta or para positions.		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9810