tectoridin has been researched along with Hyperglycemia* in 1 studies
1 other study(ies) available for tectoridin and Hyperglycemia
| Article | Year |
|---|---|
Metabolism of 6"-O-xylosyltectoridin and tectoridin by human intestinal bacteria and their hypoglycemic and in vitro cytotoxic activities.
6"-O-Xylosyltectoridin and tectoridin isolated from the flowers of Pueraria thunbergiana (Leguminosae), are metabolized to tectorigenin by human intestinal bacteria. Although tectoridin is metabolized to tectorigenin by most intestinal bacteria, 6"-O-xylosyltectoridin is metabolized to tectorigenin via tectoridin by only a few intestinal bacteria, such as Bifidobacterium breve K-110 and Eubacterium A-44. The metabolite, tectorigenin, had more potent hypoglycemic activity as well as in vitro cytotoxic activity against tumor cell lines than 6"-O-xylosyltectoridin and tectoridin. These results suggest that 6"-O-xylosyltectoridin and tectoridin are prodrugs which can be transformed to the active agents by human intestinal bacteria. Topics: Animals; Antineoplastic Agents, Phytogenic; Bifidobacterium; Drug Screening Assays, Antitumor; Eubacterium; Fabaceae; Humans; Hyperglycemia; Hypoglycemic Agents; Intestines; Isoflavones; Male; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Streptozocin; Time Factors; Tumor Cells, Cultured | 1999 |