Compounds > methyl carbazole-3-carboxylate
Page last updated: 2024-11-08

methyl carbazole-3-carboxylate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

methyl carbazole-3-carboxylate: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID504069
CHEMBL ID446253
CHEBI ID178582
SCHEMBL ID71508
MeSH IDM0537840

Synonyms (23)

Synonym
97931-41-4
CHEBI:178582
methyl 3-carbazolecarboxylate
methyl 9h-carbazole-3-carboxylate
bdbm50259669
CHEMBL446253 ,
methyl carbazole-3-carboxylate
SCHEMBL71508
AKOS022184723
9h-carbazole-3-carboxylic acid methyl ester
carbazole-3-carboxylic acid methyl ester
LZXXHWWSVRIDGR-UHFFFAOYSA-N
3-methoxycarbonylcarbazole
FS-9218
carbazole-3-carboxylic acid, methyl ester (6ci); methyl 9h-carbazole-3-carboxylate
SY254417
mfcd17214817
DTXSID701306696
methyl3-carbazolecarboxylate
Z3241269237
HY-N3288
CS-0023813
EN300-18840943
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
carbazoles
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID1151355Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced superoxide anion generation pretreated for 5 mins by spectrophotometry2014Journal of natural products, May-23, Volume: 77, Issue:5
Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity.
AID378935Cytotoxicity against human Raji cells assessed as cell viability at 0.32 nmol by trypan blue assay2000Journal of natural products, Jan, Volume: 63, Issue:1
New carbazole alkaloids from Clausena anisata with antitumor promoting activity.
AID368570Inhibition of fructose-1,6-bisphosphatase in mouse liver homogenates by colorimetric phosphate assay2009Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3
Novel heteroaromatic organofluorine inhibitors of fructose-1,6-bisphosphatase.
AID664535Antibacterial activity against Escherichia coli TISTR 780 by broth dilution method2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Bioactive carbazole alkaloids from Clausena wallichii roots.
AID664536Antibacterial activity against Salmonella typhimurium TISTR 292 by broth dilution method2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Bioactive carbazole alkaloids from Clausena wallichii roots.
AID491351Inhibition of human C-terminally His6-tagged microtubule-activated KSP motor domain ATPase activity at 20 uM after 30 mins by luciferase-derived luminescence assay2010Journal of medicinal chemistry, Jul-08, Volume: 53, Issue:13
Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds.
AID378929Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 16 nmol relative to 12-O-tetradecanoylphorbol-13-acetate2000Journal of natural products, Jan, Volume: 63, Issue:1
New carbazole alkaloids from Clausena anisata with antitumor promoting activity.
AID378932Cytotoxicity against human Raji cells assessed as cell viability at 32 nmol by trypan blue assay2000Journal of natural products, Jan, Volume: 63, Issue:1
New carbazole alkaloids from Clausena anisata with antitumor promoting activity.
AID378930Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 3.2 nmol relative to 12-O-tetradecanoylphorbol-13-acetate2000Journal of natural products, Jan, Volume: 63, Issue:1
New carbazole alkaloids from Clausena anisata with antitumor promoting activity.
AID1151356Antiinflammatory activity in human neutrophil assessed as inhibition of FMLP/CB-induced elastase release for 5 mins2014Journal of natural products, May-23, Volume: 77, Issue:5
Constituents of the roots of Clausena lansium and their potential anti-inflammatory activity.
AID378933Cytotoxicity against human Raji cells assessed as cell viability at 16 nmol by trypan blue assay2000Journal of natural products, Jan, Volume: 63, Issue:1
New carbazole alkaloids from Clausena anisata with antitumor promoting activity.
AID664534Antibacterial activity against Staphylococcus aureus TISTR 1466 by broth dilution method2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Bioactive carbazole alkaloids from Clausena wallichii roots.
AID634796Growth inhibition of human HepG2 cells after 48 hrs by WST-8 based CCK8 assay2012European journal of medicinal chemistry, Jan, Volume: 47, Issue:1
Induction of cell cycle arrest by the carbazole alkaloid Clauszoline-I from Clausena vestita D. D. Tao via inhibition of the PKCĪ“ phosphorylation.
AID378934Cytotoxicity against human Raji cells assessed as cell viability at 3.2 nmol by trypan blue assay2000Journal of natural products, Jan, Volume: 63, Issue:1
New carbazole alkaloids from Clausena anisata with antitumor promoting activity.
AID664537Cytotoxicity against human KB cells by resazurin reduction assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Bioactive carbazole alkaloids from Clausena wallichii roots.
AID664533Antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 by broth dilution method2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Bioactive carbazole alkaloids from Clausena wallichii roots.
AID664538Cytotoxicity against human MCF7 cells by resazurin reduction assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Bioactive carbazole alkaloids from Clausena wallichii roots.
AID378928Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 32 nmol relative to 12-O-tetradecanoylphorbol-13-acetate2000Journal of natural products, Jan, Volume: 63, Issue:1
New carbazole alkaloids from Clausena anisata with antitumor promoting activity.
AID378931Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as EA activation at 0.32 nmol relative to 12-O-tetradecanoylphorbol-13-acetate2000Journal of natural products, Jan, Volume: 63, Issue:1
New carbazole alkaloids from Clausena anisata with antitumor promoting activity.
AID664539Cytotoxicity against human NCI-H187 cells by resazurin reduction assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Bioactive carbazole alkaloids from Clausena wallichii roots.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.82

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.82 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.77 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.82)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.0710indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source		2.110chromones;
morpholines;
organochlorine compound		autophagy inhibitor;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor;
geroprotector
carbazole
carbazole: structure in first source		2.0510carbazole
imperatorin
imperatorin: tumor necrosis factor antagonist; furanocoumarin from West African medicinal plant Clausena anisata; structure in Negwer, 5th ed, #3005. imperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.		2.110psoralensEC 3.1.1.7 (acetylcholinesterase) inhibitor;
metabolite
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0710glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
isoimperatorin
isoimperatorin: tumor necrosis factor antagonist isolated from Glehniae root. isoimperatorin : A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 5. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.		2.110psoralensEC 3.1.1.7 (acetylcholinesterase) inhibitor;
metabolite
dictamnine
dictamnine: furanoquinoline alkaloid; crosslinks DNA in presence of ultraviolet light		2.0710alkaloid antibiotic;
organic heterotricyclic compound;
organonitrogen heterocyclic compound;
oxacycle
2-hydroxycarbazole
2-hydroxycarbazole: structure given in first source		2.0510
murrayanine
murrayanine: carbazole alkaloid from Murraya koenigii; structure in first source		2.110carbazolesmetabolite
girinimbine
girinimbine: carbazole alkaloid		2.4820carbazolesmetabolite
gamma-fagarine
gamma-fagarine: active alkaloid of Chinese medicines from Dictamni radicis cortex (Rutaceae); structure given in first source		2.0710organic heterotricyclic compound;
organonitrogen heterocyclic compound;
oxacycle
7-methoxyheptaphylline
7-methoxyheptaphylline: cytotoxic carbazole alkaloid from the roots of Clausena harmandiana; structure in first source		2.0710carbazolesmetabolite
1-(benzenesulfonyl)indole
[no description available]		2.0510sulfonamide
3-methoxy-9H-carbazole
[no description available]		2.0510carbazoles
harmine
Harmine: Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic PARKINSON DISEASE in the 1920's.. harmine : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7.		2.0510harmala alkaloidanti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
metabolite
rottlerin
rottlerin: an angiogenesis inhibitor; an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III; RN refers to (E)-isomer; do not confuse this chalcone with an anthraquinone that is also called rottlerin (RN 481-72-1);. rottlerin : A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.		2.0710aromatic ketone;
benzenetriol;
chromenol;
enone;
methyl ketone		anti-allergic agent;
antihypertensive agent;
antineoplastic agent;
apoptosis inducer;
K-ATP channel agonist;
metabolite
clausine e
clausine E: structure in first source		2.4320carbazolesmetabolite
8-geranyloxypsoralen
[no description available]		2.110terpene lactone
heptaphylline
heptaphylline: cytotoxic carbazole alkaloid from the roots of Clausena harmandiana; structure in first source		2.0710carbazolesmetabolite
osthenol
osthenol: structure in first source. osthenol : A hydroxycoumarin that is umbelliferone in which the hydrogen at position 8 has been replaced by a prenyl group.		2.110hydroxycoumarinantifungal agent;
plant metabolite
gentamicin sulfate
[no description available]		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials