4-methoxyhonokiol has been researched along with lignans in 32 studies
| Studies (4-methoxyhonokiol) | Trials (4-methoxyhonokiol) | Recent Studies (post-2010) (4-methoxyhonokiol) | Studies (lignans) | Trials (lignans) | Recent Studies (post-2010) (lignans) |
|---|---|---|---|---|---|
| 49 | 0 | 37 | 7,024 | 95 | 4,172 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (12.50) | 29.6817 |
| 2010's | 27 (84.38) | 24.3611 |
| 2020's | 1 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Bae, BK; Choi, GJ; Choi, JE; Choi, NH; Choi, YH; Jang, KS; Kang, MS; Kim, JC; Min, BS; Park, MS | 1 |
| Hong, JT; Kim, KH; Kim, KT; Kim, TI; Kim, YH; Lee, BJ; Lee, YK; Nam, SY; Yuk, DY | 1 |
| Ban, JO; Han, SB; Hong, JT; Kang, LL; Kim, KH; Kim, YH; Oh, JH | 1 |
| Choi, IS; Hong, JT; Kim, KH; Kim, YH; Lee, MS; Lee, YK; Nam, SY; Oh, KW; Yun, YW | 1 |
| Hong, JT; Kim, KH; Kim, YH; Lee, BJ; Lee, JW; Lee, SI; Lee, YK; Nam, SY; Oh, KW | 1 |
| Ban, JO; Choi, IS; Han, SB; Hong, JT; Jung, JK; Kim, KH; Kim, YH; Lee, HJ; Lee, US; Lee, YK; Oh, KW | 1 |
| Choi, IS; Han, SB; Hong, JT; Hwang, DY; Jeong, JH; Jung, JK; Kim, KH; Kim, YH; Lee, YJ; Lee, YM; Oh, KW; Park, MH; Song, JK; Yun, YP | 1 |
| Choi, DY; Choi, IS; Han, SB; Hong, JT; Hwang, DY; Jeon, YH; Jung, JK; Kim, EH; Kim, KH; Kim, YH; Lee, YH; Lee, YJ; Lee, YK; Oh, KW; Yun, YP | 1 |
| Ahn, B; Ban, JO; Cho, MC; Han, SB; Hong, JT; Jo, M; Jung, JK; Oh, JH; Yoon, DY | 1 |
| Altmann, KH; Anavi-Goffer, S; Gertsch, J; Huefner, A; Kleyer, J; Paredes, JM; Raduner, S; Schuehly, W | 1 |
| Choi, DY; Han, SB; Hong, JT; Kang, JK; Kim, KH; Kim, YH; Lee, BJ; Lee, YJ; Lee, YK; Lee, YM; Nam, SY; Oh, KW; Yun, YW | 1 |
| Cho, WG; Choi, DY; Choi, IS; Han, JY; Han, SB; Hong, JT; Jeong, JH; Jung, JK; Kim, HM; Kim, KH; Kim, YH; Lee, K; Lee, YJ; Nam, SY; Oh, KW; Yun, YW | 1 |
| Han, SB; Hong, JT; Huang, SW; Jang, JY; Jung, JK; Kim, HS; Kwak, JH; Kwak, YS; Lee, B; Lee, H; Lee, K; Lim, S; Seo, SY; Song, S | 1 |
| Ahn, BW; Ban, JO; Ham, YW; Han, SB; Hong, JT; Jung, JK; Lee, HP; Lee, NJ; Oh, JH; Shim, JH; Yoon, DY | 1 |
| Han, HK; Van Anh, LT | 1 |
| Han, SB; Hong, JT; Jung, JK; Kang, JS; Kim, HM; Kim, YH; Lee, K; Oh, SJ; Park, SK; Ryu, JK; Seo, SY; Yu, HE | 1 |
| Baek, IJ; Hong, JT; Jeong, J; Lee, BJ; Lee, JK; Lin, C; Nam, SY; Yon, JM; Yun, YW | 1 |
| Baur, R; Schuehly, W; Sigel, E | 1 |
| Cai, L; Chen, J; Conklin, DJ; Jiang, X; Kim, KH; Kim, KS; Kim, YH; Tan, Y; Wang, J; Yan, X; Zhang, Z; Zheng, Y | 1 |
| Han, SB; Hong, JT; Jung, JK; Kang, JS; Kim, HS; Kim, JS; Kim, Y; Kim, YG; Kwak, YS; Lee, HK; Lee, K; Ryu, HS; Seo, SY; Yun, J | 1 |
| Bak, Y; Ham, SY; Hong, J; Hyun, S; Kim, MS; Lee, DH; Song, YS; Yoon, DY | 1 |
| Ahn, SY; Han, JY; Hong, JT; Nam, SY; Oh, KW; Yoo, JH | 1 |
| Bae, EJ; Fei, X; Jung, JK; Ka, SO; Kim, S; Lee, Y; Park, BH; Seo, SY | 1 |
| Charles, RP; Chicca, A; Gachet, MS; Gertsch, J; Petrucci, V; Schuehly, W | 1 |
| Chae, JI; Chen, H; Cho, JH; Cho, JJ; Cho, SS; Cho, YS; Choi, NJ; Dong, Z; Hong, JT; Jeon, YJ; Jung, S; Kim, DH; Kim, KH; Lee, RH; Lee, TH; Park, HJ; Park, SM; Seo, JM; Seo, KS; Shim, JH; Shin, JC; Yoon, G | 1 |
| Cai, L; Cai, X; Chen, J; Conklin, DJ; Kim, KH; Kim, KS; Kim, YH; Tan, Y; Wang, S; Zhang, Z; Zheng, Y; Zhou, S | 1 |
| Chicca, A; de Gottardi, A; Gertsch, J; Hampe, J; Moghadamrad, S; Patsenker, E; Petrucci, V; Semmo, N; Stickel, F | 1 |
| Hong, JT; Kim, EC; Kim, JY; Park, KR; Yun, HM | 1 |
| Ashpole, NM; Ibrahim, MA; Muhammad, I; Shariat-Madar, Z; Singha, SK; Wang, M | 1 |
| Bi, L; Cai, L; Guo, H; Kim, KS; Kim, KT; Lian, X; Ma, T; Rane, MJ; Zhang, Z; Zheng, Z | 1 |
| Bi, L; Cai, L; Guo, H; Kim, KS; Kim, KT; Ma, T; Zhang, Z; Zheng, Z | 1 |
| Bennett, B; Bui, D; Cheng, G; Feng, L; Hu, M; Kalyanaraman, B; Kim, YH; Myers, CR; Pan, J; Schmainda, K; Shin, SS; Wang, Y; Xiong, D; You, M; Zhang, Q; Zielonka, J | 1 |
32 other study(ies) available for 4-methoxyhonokiol and lignans
| Article | Year |
|---|---|
Effects of neolignans from the stem bark of Magnolia obovata on plant pathogenic fungi.
Topics: Allyl Compounds; Antifungal Agents; Biphenyl Compounds; Chromatography, Thin Layer; Fungi; Lignans; Magnolia; Microbial Sensitivity Tests; Mycelium; Phenyl Ethers; Plant Bark; Plant Diseases; Plant Extracts | 2009 |
Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity.
Topics: Acetylcholinesterase; Animals; Biphenyl Compounds; Cerebral Cortex; Enzyme Activation; Ethanol; Hippocampus; Lignans; Magnolia; Male; Maze Learning; Memory; Mice; Mice, Inbred ICR; Molecular Structure; Plant Extracts | 2009 |
Anti-inflammatory effect of 4-O-methylhonokiol, compound isolated from Magnolia officinalis through inhibition of NF-kappaB [corrected].
Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Cell Line, Tumor; Cyclooxygenase 2; Ear Diseases; Edema; Lignans; Lipopolysaccharides; Magnolia; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Tetradecanoylphorbol Acetate; Transcription, Genetic | 2009 |
Neurite outgrowth effect of 4-O-methylhonokiol by induction of neurotrophic factors through ERK activation.
Topics: Animals; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Extracellular Signal-Regulated MAP Kinases; Lignans; Magnolia; Nerve Growth Factor; Neurites; Rats; Rats, Sprague-Dawley | 2009 |
Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid.
Topics: Animals; Biphenyl Compounds; Blotting, Western; Ethanol; Fluorescence; Lignans; Magnolia; Male; Memory; Mice; Mice, Inbred ICR; Neurons; PC12 Cells; Plant Extracts; Rats; Reactive Oxygen Species | 2010 |
4-O-methylhonokiol attenuated β-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Apoptosis; Astrocytes; Biphenyl Compounds; Cell Survival; Cells, Cultured; Disease Models, Animal; Hippocampus; Lignans; Lipid Peroxidation; Magnolia; Male; Memory Disorders; Mice; Mice, Inbred ICR; Neurons; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Protein Carbonylation; Reactive Oxygen Species | 2011 |
4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice through reduction of oxidative damage and inactivation of astrocytes and the ERK pathway.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Astrocytes; Biphenyl Compounds; Down-Regulation; Drug Evaluation, Preclinical; Extracellular Signal-Regulated MAP Kinases; Lignans; MAP Kinase Signaling System; Memory Disorders; Mice; Mice, Mutant Strains; Mice, Transgenic; Models, Biological; Oxidative Stress; Presenilin-2 | 2011 |
4-O-methylhonokiol attenuated memory impairment through modulation of oxidative damage of enzymes involving amyloid-β generation and accumulation in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Avoidance Learning; Biphenyl Compounds; Brain; Circular Dichroism; Disease Models, Animal; Exploratory Behavior; Humans; Lignans; Lipid Peroxidation; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Neprilysin; Presenilin-2; Protein Carbonylation; Reaction Time | 2011 |
4-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-κB activity.
Topics: Animals; Apoptosis; Biphenyl Compounds; Cell Cycle Checkpoints; Cell Proliferation; Colon; Colonic Neoplasms; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Gene Knockdown Techniques; HCT116 Cells; Humans; Lignans; Magnolia; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Plant Extracts; RNA, Small Interfering | 2012 |
Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists.
Topics: Animals; Biphenyl Compounds; Calcium; Cannabinoid Receptor Modulators; Cell Line; Cell Migration Inhibition; Cells, Cultured; Cyclic AMP; Humans; Lignans; Macrophages; Mice; Monocytes; Osteoclasts; Osteogenesis; Plant Extracts; Plants; Receptor, Cannabinoid, CB2; Tumor Necrosis Factor-alpha | 2011 |
4-O-methylhonokiol prevents memory impairment in the Tg2576 transgenic mice model of Alzheimer's disease via regulation of β-secretase activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Anti-Inflammatory Agents; Avoidance Learning; Biphenyl Compounds; Brain; Disease Models, Animal; Exploratory Behavior; Gene Expression Regulation; Glutathione; Humans; Lignans; Lipid Peroxidation; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Mutation; Oxidative Stress; Peptide Fragments; Protein Carbonylation; Time Factors | 2012 |
Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Anti-Inflammatory Agents; Aspartic Acid Endopeptidases; Astrocytes; Avoidance Learning; Biphenyl Compounds; Brain; Cell Line, Transformed; Cyclooxygenase 2; Cytokines; Dinoprostone; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Glial Fibrillary Acidic Protein; In Situ Nick-End Labeling; Inflammation; Lignans; Lipopolysaccharides; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Microglia; NF-kappa B; Nitric Oxide; Peptide Fragments | 2012 |
Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production.
Topics: Animals; Biphenyl Compounds; Cell Line; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Design; Enzyme Activation; Lignans; Macrophages; Mice; Nitric Oxide; Prostaglandins F; Structure-Activity Relationship | 2012 |
4-O-methylhonokiol, a PPARγ agonist, inhibits prostate tumour growth: p21-mediated suppression of NF-κB activity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Humans; Lignans; Male; Mice; Mice, Nude; NF-kappa B; PPAR gamma; Prostatic Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
Modulation of P-glycoprotein expression by honokiol, magnolol and 4-O-methylhonokiol, the bioactive components of Magnolia officinalis.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biphenyl Compounds; Cell Line, Tumor; Daunorubicin; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Lignans; Magnolia; Plant Extracts | 2012 |
Pharmacokinetics and metabolism of 4-O-methylhonokiol in rats.
Topics: Absorption; Animals; Biological Availability; Biphenyl Compounds; Caco-2 Cells; Cell Membrane Permeability; Cytochrome P-450 Enzyme System; Humans; Lignans; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 2014 |
4-O-methylhonokiol inhibits serious embryo anomalies caused by nicotine via modulations of oxidative stress, apoptosis, and inflammation.
Topics: Animals; Apoptosis; Biphenyl Compounds; Caspase 3; Embryo Culture Techniques; Female; Glutathione Peroxidase; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Interleukin-1beta; Lignans; Lipid Peroxidation; Lymphoma, B-Cell; Male; Mice; Mice, Inbred ICR; Nicotine; Organogenesis; Oxidative Stress; Phospholipid Hydroperoxide Glutathione Peroxidase; Pregnancy; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2014 |
Moderate concentrations of 4-O-methylhonokiol potentiate GABAA receptor currents stronger than honokiol.
Topics: Animals; Biphenyl Compounds; GABA-A Receptor Agonists; Gastrointestinal Agents; Humans; Lignans; Magnolia; Membrane Potentials; Plant Bark; Receptors, GABA-A; Xenopus laevis | 2014 |
The magnolia bioactive constituent 4-O-methylhonokiol protects against high-fat diet-induced obesity and systemic insulin resistance in mice.
Topics: Adipose Tissue; Adiposity; Animals; Biphenyl Compounds; Blood Glucose; Body Weight; Cholesterol; Diet, High-Fat; Fatty Liver; Feeding Behavior; Glucose Tolerance Test; Inflammation; Insulin; Insulin Resistance; Lignans; Lipid Metabolism; Magnolia; Male; Mice, Inbred C57BL; Obesity; Protective Agents; Triglycerides | 2014 |
Validation of cyclooxygenase-2 as a direct anti-inflammatory target of 4-O-methylhonokiol in zymosan-induced animal models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Inflammation; Lignans; Macrophages; Mice; Mice, Inbred C57BL; Zymosan | 2015 |
Peroxisome proliferator-activated receptor-gamma agonist 4-O-methylhonokiol induces apoptosis by triggering the intrinsic apoptosis pathway and inhibiting the PI3K/Akt survival pathway in SiHa human cervical cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Caspase 3; Caspase 9; Cell Line, Tumor; Female; Humans; Lignans; Mitochondria; Phosphatidylinositol 3-Kinases; PPAR gamma; Proto-Oncogene Proteins c-akt; Signal Transduction; Uterine Cervical Neoplasms | 2015 |
Alleviation of kainic acid-induced brain barrier dysfunction by 4-o-methylhonokiol in in vitro and in vivo models.
Topics: Animals; Antioxidants; Biphenyl Compounds; Blood-Brain Barrier; Brain Diseases; Capillary Permeability; Kainic Acid; Lignans; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2015 |
The new 4-O-methylhonokiol analog GS12021 inhibits inflammation and macrophage chemotaxis: role of AMP-activated protein kinase α activation.
Topics: Adenylate Kinase; Animals; Biphenyl Compounds; Cell Line; Chemotaxis; Cyclooxygenase 2; Enzyme Activation; Inflammation; Lignans; Lipopolysaccharides; Macrophages; Mice; Morpholines; Nitric Oxide Synthase Type II | 2015 |
4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Arrestins; beta-Arrestins; Biphenyl Compounds; Brain; Cell Line, Transformed; CHO Cells; Cricetulus; Cyclic AMP; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endocannabinoids; Female; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Lignans; Macrophages; Mice; Silicone Elastomers; Sulfur Isotopes; Tritium | 2015 |
Role of transcription factor Sp1 in the 4-O-methylhonokiol-mediated apoptotic effect on oral squamous cancer cells and xenograft.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Survival; Female; Gene Expression; Humans; Inhibitory Concentration 50; Lignans; Male; Mice, Nude; Middle Aged; Mouth Neoplasms; Neoplasm Transplantation; Sp1 Transcription Factor | 2015 |
Magnolia bioactive constituent 4-O-methylhonokiol prevents the impairment of cardiac insulin signaling and the cardiac pathogenesis in high-fat diet-induced obese mice.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Diet, High-Fat; Heart Function Tests; Insulin; Lignans; Magnolia; Mice; Mice, Inbred C57BL; Myocardium; Obesity; Organ Size; Oxidative Stress; Signal Transduction | 2015 |
4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice.
Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endocannabinoids; Lignans; Liver; Liver Cirrhosis; Liver Diseases, Alcoholic; Magnolia; Male; Mice, Inbred C57BL; Protective Agents | 2017 |
RANKL-induced osteoclastogenesis is suppressed by 4-O-methylhonokiol in bone marrow-derived macrophages.
Topics: Animals; Biphenyl Compounds; Bone Diseases; Cell Differentiation; Lignans; Macrophages; Magnolia; Mice; Mice, Inbred ICR; NF-kappa B; Osteoblasts; Osteoclasts; Osteogenesis; RANK Ligand; Signal Transduction | 2017 |
4-
Topics: Animals; Biphenyl Compounds; Cardiovascular System; Disease Models, Animal; Embryo, Nonmammalian; Herbal Medicine; Inflammation; Lignans; Magnolia; Male; Oryzias; Random Allocation; Signal Transduction | 2019 |
4-O-methylhonokiol ameliorates type 2 diabetes-induced nephropathy in mice likely by activation of AMPK-mediated fatty acid oxidation and Nrf2-mediated anti-oxidative stress.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diet, High-Fat; Enzyme Activation; Fatty Acids; Insulin Resistance; Kidney; Lignans; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Phytotherapy | 2019 |
4-O-methylhonokiol protects against diabetic cardiomyopathy in type 2 diabetic mice by activation of AMPK-mediated cardiac lipid metabolism improvement.
Topics: AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Fibrosis; Inflammation; Lignans; Lipid Metabolism; Male; Mice, Inbred C57BL; Models, Biological; Oxidative Stress | 2019 |
Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line, Tumor; Drug Evaluation, Preclinical; Female; Humans; Lignans; Magnolia; Mice; Mice, Nude; Mitochondria; Mouth Neoplasms; Plant Extracts; Reactive Oxygen Species | 2020 |