3,3'-diallyldiethylstilbestrol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,3'-diallyldiethylstilbestrol: RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 12/89 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	3036605
CHEMBL ID	230346
SCHEMBL ID	10016276
MeSH ID	M0170940

Synonyms (16)

Synonym
3,3'-diallyldiethylstilbestrol
4-[(1e)-1-ethyl-2-(4-hydroxy-3-prop-2-enylphenyl)but-1-enyl]-2-prop-2-enylphenol
2-allyl-4-[(e)-2-(3-allyl-4-hydroxy-phenyl)-1-ethyl-but-1-enyl]phenol
CHEMBL230346
w6u293x04b ,
unii-w6u293x04b
4870-88-6
dades
phenol, 4,4'-(1,2-diethyl-1,2-ethanediyl)bis(2-(2-propenyl)-, (e)-
SCHEMBL10016276
4,4'-stilbenediol, 3,3'-diallyl-.alpha.,.alpha.'-diethyl-, (e)-
phenol, 4,4'-((1e)-1,2-diethyl-1,2-ethenediyl)bis(2-(2-propenyl)-
4,4'-((1e)-1,2-diethyl-1,2-ethenediyl)bis(2-(2-propen-1-yl)phenol)
phenol, 4,4'-((1e)-1,2-diethyl-1,2-ethenediyl)bis(2-(2-propen-1-yl)-
(e)-4,4'-(hex-3-ene-3,4-diyl)bis(2-allylphenol)
Q27891430

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (9)

Assay ID	Title	Year	Journal	Article
AID292084	Cytotoxicity against human PBM cells	2007	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16	Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
AID292083	Antiviral activity against HIV1 in human PBM cells	2007	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16	Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
AID292081	Antiproliferative activity against mouse SVR cells at 10 ug/mL after 72 hrs	2007	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16	Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
AID292082	Antiproliferative activity against mouse SVR cells at 15 ug/mL after 72 hrs	2007	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16	Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
AID1552550	Partition coefficient, log P of the compound	2019	Bioorganic & medicinal chemistry, 08-15, Volume: 27, Issue:16	Anti-proliferative activity and structure-activity relationship of honokiol derivatives.
AID292086	Cytotoxicity against Vero cells	2007	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16	Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
AID292087	Inhibition of tumor growth in SVR cells bearing mouse up to 100 mg/kg, ip after 30 days	2007	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16	Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
AID292085	Cytotoxicity against human CEM cells	2007	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16	Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
AID292088	Toxicity against mouse up to 100 mg/kg, ip after 30 days	2007	Bioorganic & medicinal chemistry letters, Aug-15, Volume: 17, Issue:16	Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (20.00)	18.7374
1990's	2 (40.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.64 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.59 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.64)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
iodoacetamide [no description available]	1.98	1
phloretin [no description available]	1.98	1	dihydrochalcones	antineoplastic agent; plant metabolite
mannitol [no description available]	1.97	1	mannitol	allergen; antiglaucoma drug; compatible osmolytes; Escherichia coli metabolite; food anticaking agent; food bulking agent; food humectant; food stabiliser; food thickening agent; hapten; metabolite; osmotic diuretic; sweetening agent
2,2'-biphenol biphenyl-2,2'-diol : A member of the class of hydroxybiphenyls carrying hydroxy groups at positions 2 and 2'.	2.21	1	hydroxybiphenyls
8-bromo cyclic adenosine monophosphate 8-Bromo Cyclic Adenosine Monophosphate: A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.. 8-Br-cAMP : A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic AMP bearing an additional bromo substituent at position 8 on the adenine ring. An activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase.	1.97	1	3',5'-cyclic purine nucleotide; adenyl ribonucleotide; organobromine compound	antidepressant; protein kinase agonist
magnolol [no description available]	2.49	2	biphenyls
honokiol [no description available]	2.49	2	biphenyls
dihydro-dids [no description available]	1.98	1
4-methoxyhonokiol 4-methoxyhonokiol: an NSAID isolated from Magnolia obovata; structure in first source	2.21	1
oxytocin Oxytocin: A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.. oxytocin : A cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain; the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary. Together with the neuropeptide vasopressin, it is believed to influence social cognition and behaviour.	2.38	2	heterodetic cyclic peptide; peptide hormone	oxytocic; vasodilator agent
diethylstilbestrol Diethylstilbestrol: A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed). diethylstilbestrol : An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.	7.67	3	olefinic compound; polyphenol	antifungal agent; antineoplastic agent; autophagy inducer; calcium channel blocker; carcinogenic agent; EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; endocrine disruptor; xenoestrogen
4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid: A non-penetrating amino reagent (commonly called SITS) which acts as an inhibitor of anion transport in erythrocytes and other cells.	1.98	1	stilbenoid
cytochalasin b Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.. cytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.	1.98	1	cytochalasin; lactam; lactone; organic heterotricyclic compound	actin polymerisation inhibitor; metabolite; mycotoxin; platelet aggregation inhibitor
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid: An inhibitor of anion conductance including band 3-mediated anion transport.	1.98	1
pituitrin Pituitrin: A substance or extract from the neurohypophysis (PITUITARY GLAND, POSTERIOR).	1.97	1

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