Compounds > nucleocidin
Page last updated: 2024-11-06

nucleocidin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

nucleocidin: adenine nucleoside; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

nucleocidin : A nucleoside antibiotic that is 5'-O-sulfamoyladenosine in which the hydrogen atom at position 4' is replaced by a fluorine atom. It is a natural product synthesized by several Streptomyces species. It exhibits broad spectrum antibacterial activity, and also has a strong effect against Trypanosoma brucei, the protozoan parasite responsible for the African sleeping sickness. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID72299
CHEBI ID166872
SCHEMBL ID3978671
MeSH IDM0046798

Synonyms (20)

Synonym
nulceocidin
antibiotic t-3018
nsc 521007
4'-c-fluoroadenosine 5'-sulfamate
9-(4-fluoro-5-o-sulfamoylpentofuranosyl)adenine
t-3018
adenosine, 4'-c-fluoro-, 5'-sulfamate
CHEBI:166872
[(2s,3s,4r,5r)-5-(6-aminopurin-9-yl)-2-fluoro-3,4-dihydroxyoxolan-2-yl]methyl sulfamate
4'-fluoro-5'-o-sulphamoyladenosine
nucleocidin
4'-fluoro-5'-o-sulfamoyladenosine
[(2s,3s,4r,5r)-5-(6-aminopurin-9-yl)-2-fluoro-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl sulfamate
f5097ng7jt ,
unii-f5097ng7jt
SCHEMBL3978671
nucleocidin [mi]
HY-100496
CS-0019532
Q27277644

Research Excerpts

Overview

Nucleocidin is an adenosine derivative containing 4'-fluoro and 5'-O-sulfamoyl substituents.

ExcerptReferenceRelevance
"Nucleocidin is an adenosine derivative containing 4'-fluoro and 5'-O-sulfamoyl substituents. "( Identification of Genes Essential for Sulfamate and Fluorine Incorporation During Nucleocidin Biosynthesis.
Bechthold, A; Pasternak, ARO; Zechel, DL, 2022)		2.39
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (5)

RoleDescription
bacterial metaboliteAny prokaryotic metabolite produced during a metabolic reaction in bacteria.
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
trypanocidal drugA drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida.
protein synthesis inhibitorA compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
nucleoside antibioticnull
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
adenosinesAny purine ribonucleoside that is a derivative of adenosine.
organofluorine compoundAn organofluorine compound is a compound containing at least one carbon-fluorine bond.
sulfamate ester
6-aminopurinesAny compound having 6-aminopurine (adenine) as part of its structure.
diolA compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (33.33)18.7374
1990's1 (6.67)18.2507
2000's0 (0.00)29.6817
2010's4 (26.67)24.3611
2020's5 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.06

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.06 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (25.06)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.88%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (94.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		7.5420alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
sulfamic acid
sulfamic acid: standard in alkalimetry; RN given refers to parent cpd; structure. sulfamic acid : The simplest of the sulfamic acids consisting of a single sulfur atom covalently bound by single bonds to hydroxy and amino groups and by double bonds to two oxygen atoms.		2.4110sulfamic acids
puromycin aminonucleoside
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine: structure in first source. 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine : Puromycin derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring.		1.95103'-deoxyribonucleoside;
adenosines
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		2.1310dihydrogen
fluorine
Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.		9.2950diatomic fluorine;
gas molecular entity		NMR chemical shift reference compound
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit		3.85120adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
diethylaminosulfur trifluoride
diethylaminosulfur trifluoride: fluorinating agent for carbohydrates		1.9810
5'-deoxyadenosine
5'-deoxyadenosine: main heading DEOXYADENOSINE refers to the 3' cpd. 5'-deoxyadenosine : A 5'-deoxyribonucleoside compound having adenosine as the nucleobase.		2.6105'-deoxyribonucleoside;
adenosines		Escherichia coli metabolite;
human metabolite;
mouse metabolite
puromycin
[no description available]		6.9510puromycinsantiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
African Sleeping Sickness
[description not available]		02.3420
Trypanosomiasis
Infection with protozoa of the genus TRYPANOSOMA.		02.3420
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.		02.3420