Target type: biologicalprocess
Any process that activates or increases the frequency, rate, or extent of tissue remodeling. [GOC:add]
Positive regulation of tissue remodeling is a complex biological process that involves the coordinated action of various cells, signaling molecules, and extracellular matrix components. It plays a crucial role in maintaining tissue homeostasis, wound healing, and development. The process begins with the detection of tissue damage or changes in the cellular environment. This triggers a cascade of signaling events that activate specific cellular responses. Key players in this process include growth factors, cytokines, and chemokines, which promote cell proliferation, migration, differentiation, and extracellular matrix remodeling. For instance, transforming growth factor beta (TGF-β) is a key regulator of tissue remodeling, promoting fibroblast proliferation and collagen deposition. Other growth factors, such as fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF), also contribute to tissue remodeling by stimulating cell growth and migration. Cytokines, like tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1), can both promote and suppress tissue remodeling depending on the context. They can induce inflammation, attract immune cells, and modulate the activity of other signaling molecules. Chemokines, such as CCL2 and CXCL8, play a role in attracting immune cells, such as macrophages, to the site of tissue damage. The process of tissue remodeling involves the breakdown and rebuilding of the extracellular matrix (ECM), which provides structural support and regulates cell behavior. Enzymes, such as matrix metalloproteinases (MMPs), degrade the ECM, allowing for cell migration and new tissue formation. Conversely, other enzymes, such as tissue inhibitors of metalloproteinases (TIMPs), inhibit MMP activity, preventing excessive ECM degradation. The coordination of these processes ensures that tissue remodeling occurs in a controlled and efficient manner. However, dysregulation of tissue remodeling can lead to various pathological conditions, including fibrosis, cancer, and inflammatory diseases. For example, excessive ECM deposition can lead to fibrosis, while impaired tissue remodeling can contribute to wound healing complications.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Interleukin-2 | An interleukin-2 that is encoded in the genome of human. [PRO:CNA, UniProtKB:P60568] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| daidzin | daidzein 7-O-beta-D-glucoside : A glycosyloxyisoflavone that is daidzein attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It is used in the treatment of alcohol dependency (antidipsotropic). daidzin: a potent, selective, and reversible inhibitor of human mitochondrial aldehyde dehydrogenase | 7-hydroxyisoflavones 7-O-beta-D-glucoside; hydroxyisoflavone; monosaccharide derivative | plant metabolite |
| ononin | 4'-methoxyisoflavones; 7-hydroxyisoflavones 7-O-beta-D-glucoside; monosaccharide derivative | plant metabolite | |
| formononetin | 4'-methoxyisoflavones; 7-hydroxyisoflavones | phytoestrogen; plant metabolite | |
| luteolin-7-glucoside | luteolin 7-O-beta-D-glucoside : A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. luteolin-7-glucoside: has both antiasthmatic and antineoplastic activities; has 3C protease inhibitory activity; isolated from Ligustrum lucidum | beta-D-glucoside; glycosyloxyflavone; monosaccharide derivative; trihydroxyflavone | antioxidant; plant metabolite |
| N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide | N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide : A leucine derivative obtained by fpormal condensation of the secondary amino group of 5-({2,3-dichloro-4-[1-methyl-5-(piperidin-4-yl)-1H-pyrazol-3-yl]phenoxy}methyl)-2-furoic acid and the carboxy group of N-amidino-L-leucylglycine | D-leucine derivative; dichlorobenzene; furoic acid; glycine derivative; guanidines; pyrazolylpiperidine | |
| calycosin-7-o-beta-d-glucopyranoside | calycosin-7-O-beta-D-glucoside : A glycosyloxyisoflavone that is calycosin substituted by a beta-D-glucopyranosyl residue at position at 7 via a glycosidic linkage. calycosin-7-O-beta-D-glucoside: from Radix Astragali | 4'-methoxyisoflavones; 7-hydroxyisoflavones 7-O-beta-D-glucoside; hydroxyisoflavone; monosaccharide derivative | |
| diosgenin glucoside | diosgenin 3-O-beta-D-glucoside : A sterol 3-beta-D-glucoside having diosgenin as the sterol component. diosgenin glucoside: RN given refers to (3beta,25R)-isomer; structure given in first source | hexacyclic triterpenoid; monosaccharide derivative; spiroketal; sterol 3-beta-D-glucoside | metabolite |