Compounds > malonylgenistin
Page last updated: 2024-11-12

malonylgenistin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

malonylgenistin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

malonylgenistin : A glycosyloxyisoflavone that is genistin in which the hydroxy hydrogen at position 6'' has been replaced by a malonyl group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID15934091
CHEMBL ID3426722
CHEBI ID80372
MeSH IDM0511530

Synonyms (32)

Synonym
51011-05-3
malonylgenistin
MEGXP0_000226
ACON0_001356
genistin malonate
genistin 6''-o-malonate
7-o-glucosyl-6''-malonyl genistein
CHEBI:80372 ,
5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4h-1-benzopyran-7-yl 6-o-(carboxyacetyl)-beta-d-glucopyranoside
genistein 7-o-beta-d-glucoside 6''-o-malonate
CS-4241
propanedioic acid, 6'-ester with 7-(beta-d-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-one
genistein-7-o-beta-d-glucosyl-6''-o-malonate
unii-2aub85vt2k
propanedioic acid, 6'-ester with 7-(.beta.-d-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-one
5-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4h-chromen-7-yl 6-o-(carboxylatoacetyl)hexopyranoside
2AUB85VT2K ,
genistein-7-o-.beta.-d-glucosyl-6''-o-malonate
malonyl genistin (constituent of soy isoflavones) [dsc]
HY-N0917
CHEMBL3426722
AKOS030526829
6-o-malonylgenistin, free acid
genistein 7-o-beta-d-glucoside-6''-o-malonate
malonyl-genistin
FRAUJUKWSKMNJY-RSEYPYQYSA-N
malonyl genistin
3-oxo-3-[[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-[5-hydroxy-3-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxyoxan-2-yl]methoxy]propanoic acid
Q27149379
MS-29612
6-o-malonylgenistin
DTXSID201316854

Research Excerpts

Compound-Compound Interactions

ExcerptReferenceRelevance
"The crude methanol extract of Pueraria lobata was investigated by dual high-resolution α-glucosidase inhibition and radical scavenging profiling combined with hyphenated HPLC-HRMS-SPE-NMR."( Dual high-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of minor and major constituents directly from the crude extract of Pueraria lobata.
Jäger, AK; Kongstad, KT; Liu, B; Nyberg, NT; Qinglei, S; Staerk, D, 2015)		0.42

Bioavailability

ExcerptReferenceRelevance
"Despite considerable interest in the physiologic effects of isoflavones, the in vivo bioavailability of the most common isoflavone forms, malonylglucoside conjugates, has not been determined."( Malonylglucoside conjugates of isoflavones are much less bioavailable compared with unconjugated β-glucosidic forms in rats.
Gallaher, DD; Ismail, B; Yerramsetty, V, 2014)		0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
glycosyloxyisoflavoneA member of the class of isoflavones having one or more glycosyl residues attached at unspecified positions.
hydroxyisoflavoneMember of the class of isoflavones bearing at least one hydroxy group.
malonate esterAn ester of malonic acid; any compound containing a malonate ester skeleton.
monosaccharide derivativeA carbohydrate derivative that is formally obtained from a monosaccharide.
beta-D-glucosideAny D-glucoside in which the anomeric centre has beta-configuration.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1204997Antioxidant activity of the compound assessed as inhibition of ABTS radicals after 20 mins by spectrophotometric analysis2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Dual high-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of minor and major constituents directly from the crude extract of Pueraria lobata.
AID1204996Inhibition of Saccharomyces cerevisiae alpha-glucosidase type 1 assessed as 4-nitrophenol cleavage product by high-resolution biochromatogram2015Journal of natural products, Feb-27, Volume: 78, Issue:2
Dual high-resolution α-glucosidase and radical scavenging profiling combined with HPLC-HRMS-SPE-NMR for identification of minor and major constituents directly from the crude extract of Pueraria lobata.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (8.33)29.6817
2010's8 (66.67)24.3611
2020's3 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.78 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.71 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
allantoin
[no description available]		2.2110imidazolidine-2,4-dione;
ureas		Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite;
vulnerary
phenol
[no description available]		2.1110phenolsantiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite
ethylene
Plastipore: high density polyethylene sponge biocompatible material; used as posts in dental bridges		2.1310alkene;
gas molecular entity		plant hormone;
refrigerant
cyclopentane
Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.		2.1310cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		2.110dihydrogen
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		3.93110D-glucopyranoseepitope;
mouse metabolite
daidzin
daidzin: a potent, selective, and reversible inhibitor of human mitochondrial aldehyde dehydrogenase. daidzein 7-O-beta-D-glucoside : A glycosyloxyisoflavone that is daidzein attached to a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. It is used in the treatment of alcohol dependency (antidipsotropic).		3.64807-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative		plant metabolite
glycitin
glycitin: structure in first source. glycitin : A glycosyloxyisoflavone that is isoflavone substituted by a methoxy group at position 6, a hydroxy group at position 4' and a beta-D-glucopyranosyloxy group at position 7.		2.85307-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
methoxyisoflavone;
monosaccharide derivative		plant metabolite
ononin
[no description available]		2.11104'-methoxyisoflavones;
7-hydroxyisoflavones 7-O-beta-D-glucoside;
monosaccharide derivative		plant metabolite
glycosides
[no description available]		2.5820
Jasmone
jasmone: RN refers to (Z)-isomer; structure given in first source		2.1310cyclic ketone
1,1-diphenyl-2-picrylhydrazyl
1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)		2.1110
formononetin
[no description available]		2.11104'-methoxyisoflavones;
7-hydroxyisoflavones		phytoestrogen;
plant metabolite
genistein
[no description available]		3.26507-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
genistin
genistin: glycoside of soy bean isoflavone, gentistein		3.53707-hydroxyisoflavones 7-O-beta-D-glucoside
daidzein
[no description available]		3.39607-hydroxyisoflavonesantineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite
genistein-8-c-glucoside
genistein 8-C-glucoside : A C-glycosyl compound that is genistein substituted by a beta-D-glucopyranosyl residue at position 8 via a C-glucosidic linkage.		2.11107-hydroxyisoflavones;
C-glycosyl compound		plant metabolite
puerarin
[no description available]		2.1110C-glycosyl compound;
hydroxyisoflavone		plant metabolite
glycitein
glycitein : A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 7 and 4'. It has been isolated from the mycelia of the fungus Cordyceps sinensis.		2.84307-hydroxyisoflavone;
methoxyisoflavone		fungal metabolite;
phytoestrogen;
plant metabolite
strontium
Strontium: An element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62.		2.2110alkaline earth metal atom
beta-escin
[no description available]		2.1110
6''-o-malonyldaidzin
6''-O-malonyldaidzin: structure in first source. malonyldaidzin : A glycosyloxyisoflavone that is daidzein substituted by a 6-O-(carboxyacetyl)-beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage.		3.6280glycosyloxyisoflavone;
hydroxyisoflavone;
malonate ester;
monosaccharide derivative		plant metabolite
chlorophyll a
Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.		2.2110chlorophyll;
methyl ester		cofactor
phytoestrogens
Phytoestrogens: Compounds derived from plants, primarily ISOFLAVONES that mimic or modulate endogenous estrogens, usually by binding to ESTROGEN RECEPTORS.		2.2110
ConditionIndicatedRelationship StrengthStudiesTrials