Page last updated: 2024-11-07

((18)O)water

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

((18)O)water, also known as heavy water, is a naturally occurring form of water that contains an isotope of oxygen, oxygen-18 (18O). It has two hydrogen atoms bonded to an oxygen-18 atom. ((18)O)water has a higher molecular weight than regular water (H2O), which gives it slightly different physical and chemical properties. It is used in various scientific research fields, including environmental science, hydrology, and climate science. It is a vital tool for understanding the global water cycle, as it is used to track the movement of water in the environment. ((18)O)water is often used as a tracer in hydrological studies to determine the sources and ages of groundwater, the rates of evaporation and transpiration, and the flow paths of rivers and streams. It is also used to study the effects of climate change on water resources.'

((18)O)water : A form of water consisting of two hydrogen atoms covalently bonded to an oxygen-18 atom. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

oxygen-18 atom : The stable isotope of oxygen with relative atomic mass 17.999160 and 0.205 atom percent natural abundance. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID105142
CHEBI ID33813
CHEBI ID33815

Synonyms (50)

Synonym
water, heavy (h218o)
water, labeled with oxygen-18
7qv8f8bynj ,
water (h218o)
water o-18
unii-7qv8f8bynj
14314-42-2
(18)oh2
((18)o)water
water-(18)o
h2(18)o
heavy-oxygen water
CHEBI:33813
water-18o
heavy oxygen
14797-71-8
oxygen-18 atom
schwerer sauerstoff
oxygen-18
(18)o
oxygen, isotope of mass 18
CHEBI:33815
(18)8o
water-18o, 99 atom % 18o
water-18o, 10 atom % 18o
water-18o, 97 atom % 18o
A808025
oxygen, isotope of mass 18, at.
AKOS015903635
heavy water (h218o)
water, o-18
water-18o, normalized
mfcd00064503
water-18o, 70 atom % 18o
water-18o, 98 atom % 18o
water-18o, 80 atom % 18o
h218o
J-007751
water-(18-o) (97% isotopic purity)
[o-18]-water
DTXSID40933267
(~18~o)water
Q27115709
Q662269
18o water
MS-22712
water-(18-o) (99% isotopic purity)
CS-0459820
HY-108872S
water-(18-o) (10% isotopic purity)

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" To differentiate between physiologic and methodologic sources of variation, the urine samples from 54 subjects were divided and blinded and analyzed separately, and repeated DLW dosing was performed in an additional 55 participants after 6 mo."( Dilution space ratio of 2H and 18O of doubly labeled water method in humans.
Racine, NM; Sagayama, H; Schoeller, DA; Shriver, TC; Yamada, Y, 2016
)
0.43
" Some determine dilution spaces using isotope enrichments extrapolated to the instant of dosing with DLW (slope-intercept method), but others use measured enrichments from body water samples obtained 3-10 h after dosing (plateau method)."( Method and rationale for recalculating dilution spaces to a single, common time point in doubly labeled water studies.
Pontzer, H, 2018
)
0.48
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
waterAn oxygen hydride consisting of an oxygen atom that is covalently bonded to two hydrogen atoms
isotopically modified compoundAny molecular entity in which the isotopic ratio of nuclides for at least one element deviates measurably from that occurring in nature. The term includes both isotopically substituted compounds (in which essentially all the molecules of the compound have only the indicated nuclide(s) at each designated position) and isotopically labeled compounds (a formal mixture of an isotopically unmodified compound with one or more analogous isotopically substituted compound(s).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (144)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's68 (47.22)24.3611
2020's76 (52.78)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.53 (24.57)
Research Supply Index5.00 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index44.85 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (1.38%)5.53%
Reviews4 (2.76%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other139 (95.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]