protoapigenone has been researched along with diisopropyl-ether* in 1 studies
1 other study(ies) available for protoapigenone and diisopropyl-ether
Article | Year |
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Less Cytotoxic Protoflavones as Antiviral Agents: Protoapigenone 1'-
Protoflavones, a rare group of natural flavonoids with a non-aromatic B-ring, are best known for their antitumor properties. The protoflavone B-ring is a versatile moiety that might be explored for various pharmacological purposes, but the common cytotoxicity of these compounds is a limitation to such efforts. Protoapigenone was previously found to be active against the lytic cycle of Epstein-Barr virus (EBV). Further, the 5-hydroxyflavone moiety is a known pharmacophore against HIV-integrase. The aim of this work was to prepare a series of less cytotoxic protoflavone analogs and study their antiviral activity against HIV and EBV. Twenty-seven compounds, including 18 new derivatives, were prepared from apigenin through oxidative de-aromatization and subsequent continuous-flow hydrogenation, deuteration, and/or 4'-oxime formation. One compound was active against HIV at the micromolar range, and three compounds showed significant activity against the EBV lytic cycle at the medium-low nanomolar range. Among these derivatives, protoapigenone 1'- Topics: Antineoplastic Agents; Cyclohexanones; Ethers; Flavones; Herpesvirus 4, Human; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Structure-Activity Relationship; Virus Physiological Phenomena; Virus Replication | 2019 |