Page last updated: 2024-09-27

DNA Degradation, Necrotic

The random catabolism of DNA accompanying the irreversible damage to tissue which leads to the pathological death of one or more cells.

Synonyms(2)

Synonym
DNA Degradation, Necrotic
Necrotic DNA Degradation

Research

Studies (33)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's10 (30.30)18.1394
2010's19 (57.58)28.8240
2020's4 (12.12)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low10
cytosine0low20
dimethyl sulfoxide0low10
formaldehyde0low40
nitrates0low10
phenol0low10
sarcosine0low10
acetaminophen0low10
diazinon0low10
2-propanol0low10
fluoroacetic acid0low10
aspartic acid0low10
edetic acid0low20
chloroform0low10
benzidine0low10
sarin0low10
mustard gas0low10
luminol0low10
acetylcysteine0low10
c.i. 425100low10
sodium hydroxide0low10
carbonates0low10
ammonium nitrate0low10
4-methoxyamphetamine0low10
indigo carmine0low10
methyl-thiohydantoin-tryptophan0low10
mastoparan0low10
oligonucleotides0low10
hoe 333420low10
chitosan0low10
sodium hypochlorite0low10
sarkosyl0low10
interleukin-80low10
3-methyladenine0low10
trypan blue0low10

Protein Targets (302)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit3003
RAR-related orphan receptor gamma9009
GLI family zinc finger 36006
AR protein9009
aldehyde dehydrogenase 1 family, member A16006
retinoic acid nuclear receptor alpha variant 1120012
retinoid X nuclear receptor alpha9009
estrogen nuclear receptor alpha150015
peroxisome proliferator-activated receptor delta5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
activating transcription factor 61001
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Histone H2A.x6006
thyroid hormone receptor beta isoform a4004
heat shock protein beta-15005
nuclear factor erythroid 2-related factor 2 isoform 1100010
lamin isoform A-delta104004
Voltage-dependent calcium channel gamma-2 subunit7007
Glutamate receptor 27007
Chain A, DNA-3-methyladenine glycosylase I0011
Chain A, DNA-3-METHYLADENINE GLYCOSYLASE I0011
Chain A, Dna-3-methyladenine Glycosylase I0011
EWS/FLI fusion protein3003
5-hydroxytryptamine receptor 2C0112
5-hydroxytryptamine receptor 2A0112
5-hydroxytryptamine receptor 1A0112
5-hydroxytryptamine receptor 1B0112
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0112
5-hydroxytryptamine receptor 60011
Sodium-dependent serotonin transporter0011
Sodium-dependent serotonin transporter0101
5-hydroxytryptamine receptor 7 0011
5-hydroxytryptamine receptor 5A0011
5-hydroxytryptamine receptor 5B0011
5-hydroxytryptamine receptor 3A0011
5-hydroxytryptamine receptor 4 0011
5-hydroxytryptamine receptor 3B0011
ATAD5 protein, partial1001
GLS protein2002
Microtubule-associated protein tau3003
Smad31001
thyroid stimulating hormone receptor2002
nuclear receptor subfamily 1, group I, member 37007
progesterone receptor5005
estrogen-related nuclear receptor alpha110011
peroxisome proliferator activated receptor gamma3003
aryl hydrocarbon receptor5005
chromobox protein homolog 11001
thyroid hormone receptor beta isoform 27007
peripheral myelin protein 222002
cytochrome P450 3A4 isoform 14004
Gamma-aminobutyric acid receptor subunit pi4004
ATP-binding cassette sub-family C member 30101
Multidrug resistance-associated protein 40101
Solute carrier family 22 member 60202
Carbonic anhydrase 120202
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0101
Bile salt export pump0202
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10506
Carbonic anhydrase 20506
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10101
Carbonic anhydrase 30202
Cytochrome P450 3A40101
Cytochrome P450 2D60101
Cytochrome P450 2C9 0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-14004
Sulfotransferase 1A1 0002
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
UDP-glucuronosyltransferase 1-60001
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40404
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60303
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
Carbonic anhydrase 5A, mitochondrial0202
Prostaglandin G/H synthase 20001
Carbonic anhydrase 70202
Nuclear receptor ROR-gamma3003
Cytochrome P450 2J20101
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
Carbonic anhydrase 90202
GABA theta subunit4004
Canalicular multispecific organic anion transporter 10101
Carbonic anhydrase 150404
Carbonic anhydrase 130202
Gamma-aminobutyric acid receptor subunit epsilon4004
Carbonic anhydrase 140202
Carbonic anhydrase 5B, mitochondrial0202
toxin B0001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, 2-oxoglutarate Oxygenase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
acetylcholinesterase2002
dopamine D1 receptor1001
15-lipoxygenase, partial1001
pregnane X receptor2002
phosphopantetheinyl transferase3003
USP1 protein, partial2002
NFKB1 protein, partial1001
Thrombopoietin1001
regulator of G-protein signaling 41001
glucocorticoid receptor [Homo sapiens]5005
farnesoid X nuclear receptor2002
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 23003
Bloom syndrome protein isoform 12002
D(1A) dopamine receptor1001
flap endonuclease 11001
geminin4004
survival motor neuron protein isoform d2002
muscarinic acetylcholine receptor M11001
Histone deacetylase 30101
Histone deacetylase 40101
Guanine nucleotide-binding protein G2002
Histone deacetylase 10101
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Ataxin-25005
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
ATP-dependent phosphofructokinase1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
TDP1 protein3003
cytochrome P450 family 3 subfamily A polypeptide 42002
pregnane X nuclear receptor3003
nuclear factor erythroid 2-related factor 2 isoform 21001
importin subunit beta-1 isoform 13003
snurportin-13003
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 13003
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 432002
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 54004
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Ferritin light chain1001
cytochrome P450 2C19 precursor1001
lethal factor (plasmid)1001
Metabotropic glutamate receptor 60011
Excitatory amino acid transporter 40101
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0101
Excitatory amino acid transporter 10101
Excitatory amino acid transporter 20101
Excitatory amino acid transporter 30101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 20011
Carbonic anhydrase-like protein, putative0001
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Carbonic anhydrase 40001
Glutamate receptor ionotropic, NMDA 3A0101
Luciferase3003
estrogen receptor 2 (ER beta)2002
thyroid stimulating hormone receptor3003
cellular tumor antigen p53 isoform a3003
histone deacetylase 9 isoform 32002
rac GTPase-activating protein 1 isoform a0101
Integrin beta-33003
Integrin alpha-IIb3003
UDP-glucuronosyltransferase 1A40001
nuclear receptor subfamily 1, group I, member 21001
Cellular tumor antigen p534004
Carbonic anhydrase0202
interleukin 81001
IDH11001
Deoxycytidine kinase0001
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
isocitrate dehydrogenase 1, partial1001
G1001
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Acetylcholinesterase0101
Rap guanine nucleotide exchange factor 41001
Inositol hexakisphosphate kinase 11001
cytochrome P450 2C9, partial1001
Cereblon isoform 40202
Insulin-like growth factor-binding protein 50011
Choline O-acetyltransferase 0101
Protein cereblon0202
Eyes absent homolog 20101
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Amyloid-beta precursor protein0101
Angiotensin-converting enzyme 0101
Histamine H2 receptor1001
Metallo-beta-lactamase VIM-130101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase VIM-1 0101
thioredoxin reductase1001
tumor necrosis factor1001
NEDD8-activating enzyme E1 regulatory subunit isoform a0101
NEDD8-conjugating enzyme Ubc120101
Queuine tRNA-ribosyltransferase0101
alpha-galactosidase2002
nuclear receptor ROR-gamma isoform 11001
Indoleamine 2,3-dioxygenase 10202
Receptor-interacting serine/threonine-protein kinase 10112
Sodium/iodide cotransporter0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Penicillin Amidohydrolase0101
Chain B, Penicillin Amidohydrolase0101
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Lysozyme0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
Chain A, Ferritin light chain0011
cytochrome P450 2D61001
Polyphenol oxidase 20001
Endolysin0011
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit gamma-20011
Cannabinoid receptor 10101
Adenosine receptor A10101
Adenosine receptor A2a0101
Gamma-aminobutyric acid receptor subunit beta-20011
Spike glycoprotein1001
Carbonic anhydrase 0101
Beta-carbonic anhydrase 10101
Carbonic anhydrase0101
Carbonic anhydrase 0101
Carbonic anhydrase 30202
Carbonic anhydrase0101
Carbonic anhydrase 130101
Chain A, Beta-lactamase1001
DNA polymerase iota isoform a (long)1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Sodium- and chloride-dependent glycine transporter 10101
Proton-coupled amino acid transporter 10101
Acetylcholinesterase0011
Peroxisome proliferator-activated receptor alpha1001
mitogen-activated protein kinase 11001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]