2,6-lutidine profile

2,6-Lutidine, also known as 2,6-dimethylpyridine, is a colorless, flammable liquid with a pungent odor. It is a derivative of pyridine with two methyl groups at positions 2 and 6. 2,6-Lutidine is synthesized through various methods, including the reaction of 2,6-dimethylphenol with ammonia and the catalytic hydrogenation of 2,6-dimethylnitrobenzene. It is a versatile compound with applications in various fields. For instance, it is used as a solvent in organic synthesis, a catalyst in various reactions, and a precursor for the production of pharmaceuticals and agrochemicals. The compound's unique properties, such as its basicity and its ability to form coordination complexes with metal ions, make it an interesting subject of research in fields like catalysis and coordination chemistry. The study of 2,6-lutidine can lead to the development of new and improved catalysts for various chemical reactions and the synthesis of new compounds with unique properties. '

2,6-dimethylpyridine : A member of the class of methylpyridines that is pyridine carrying methyl substituents at positions 2 and 6. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	7937
CHEMBL ID	22976
CHEBI ID	32548
SCHEMBL ID	9611
MeSH ID	M0060589

Synonym
AC-5116
EN300-19113
108-48-5
.alpha.,.alpha.'-lutidine
nsc2155
2,6-dimethylpyridine
nsc-2155
.alpha.,.alpha.'-dimethylpyridine
2,6-lutidine
ai3-24282
hsdb 79
2,6-dimethypyridine
fema no. 3540
nsc 2155
einecs 203-587-3
AC-907/25014177
alpha,alpha'-dimethylpyridine
LUT ,
alpha,alpha'-lutidine
lutidine
CHEBI:32548 ,
pyridine, 2,6-dimethyl-
inchi=1/c7h9n/c1-6-4-3-5-7(2)8-6/h3-5h,1-2h
2,6-dimethylpyridine, >=99%
2,6-lutidine, reagentplus(r), 98%
2,6-lutidine, purified by redistillation, >=99%
CHEMBL22976
2,6-dimethyl-pyridine
L0067
A801883
STL163956
BBL013176
AKOS005716680
unii-15fq5d0t3p
15fq5d0t3p ,
FT-0610735
2,6-lutidine [mi]
2,6-dimethylpyridine [fhfi]
dimethylpyridine, 2,6-
2,6-lutidine [hsdb]
BP-30085
SCHEMBL9611
2,6 lutidine
2-6-lutidine
2,6lutidine
2,6-dimethyl pyridine
2,6- lutidine
lutidin
2,6 -lutidine
2,6-dimethyl pyridin
2.6-dimethylpyridine
2,6-lutidene
2.6-lutidine
2,6-dimethylpiridine
tox21_303862
NCGC00357127-01
dtxcid1030109
dtxsid7051557 ,
cas-108-48-5
Q-100049
.alpha.,.alpha.'-lutidin
mfcd00006345
F0001-0171
alpha,alpha'-lutidin
2,6-lutidine, analytical standard
2,6-dimethylpyridine, redistilled
2,6-lutidine, 8ci
fema 3540
135742-47-1
2,6-dimethylpyridine-d9
2,6-litidine-d6
Q209284
AM10711
2,6-lutidine (8ci); 2,6-dimethylpyridine; nsc 2155; ?,?'-dimethylpyridine; ?,?'-lutidine
BP-31131
Z104472820
F91703

Class	Description
methylpyridines	Any member of the class of pyridines that carries at least one methyl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID30377	Maximum percent of enhancement of binding.	1985	Journal of medicinal chemistry, Sep, Volume: 28, Issue:9	Structure-activity relationships of some pyridine, piperidine, and pyrrolidine analogues for enhancing and inhibiting the binding of (+/-)-[3H]nicotine to the rat brain P2 preparation.
AID30378	Maximum percent of inhibition of binding was determined	1985	Journal of medicinal chemistry, Sep, Volume: 28, Issue:9	Structure-activity relationships of some pyridine, piperidine, and pyrrolidine analogues for enhancing and inhibiting the binding of (+/-)-[3H]nicotine to the rat brain P2 preparation.
AID30518	Compounds was evaluate for their ability to enhance (+/-)-[3H]nicotine binding at a dose range 10 E -10 - 10 E -4 M was reported	1985	Journal of medicinal chemistry, Sep, Volume: 28, Issue:9	Structure-activity relationships of some pyridine, piperidine, and pyrrolidine analogues for enhancing and inhibiting the binding of (+/-)-[3H]nicotine to the rat brain P2 preparation.
AID30385	Compound was evaluated for ability to enhance the binding of (+/-)-[3H]nicotine to the rat brain P2 fraction at binding site 1; 10e-9-10e-4	1985	Journal of medicinal chemistry, Sep, Volume: 28, Issue:9	Structure-activity relationships of some pyridine, piperidine, and pyrrolidine analogues for enhancing and inhibiting the binding of (+/-)-[3H]nicotine to the rat brain P2 preparation.
AID30389	Ability to enhance the binding of (+/-)-[3H]nicotine to the rat brain P2 fraction at binding site 2	1985	Journal of medicinal chemistry, Sep, Volume: 28, Issue:9	Structure-activity relationships of some pyridine, piperidine, and pyrrolidine analogues for enhancing and inhibiting the binding of (+/-)-[3H]nicotine to the rat brain P2 preparation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (24.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (24.00)	29.6817
2010's	11 (44.00)	24.3611
2020's	2 (8.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	26 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
diacetyl butane-2,3-dione : An alpha-diketone that is butane substituted by oxo groups at positions 2 and 3. It is a metabolite produced during the malolactic fermentation.	7.13	1	alpha-diketone	Escherichia coli metabolite; Saccharomyces cerevisiae metabolite
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2.1	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.02	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
nickel Nickel: A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.. nickel ion : A nickel atom having a net electric charge.. nickel atom : Chemical element (nickel group element atom) with atomic number 28.	2.03	1	metal allergen; nickel group element atom	epitope; micronutrient
pyrazole 1H-pyrazole : The 1H-tautomer of pyrazole.	2.08	1	pyrazole
pyridine azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.	7.7	3	azaarene; mancude organic heteromonocyclic parent; monocyclic heteroarene; pyridines	environmental contaminant; NMR chemical shift reference compound
anabasine [no description available]	1.96	1	piperidine alkaloid; pyridine alkaloid	nicotinic acetylcholine receptor agonist; plant metabolite; teratogenic agent
mecamylamine Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.	1.96	1	primary aliphatic amine
carbachol Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.	1.96	1	ammonium salt; carbamate ester	cardiotonic drug; miotic; muscarinic agonist; nicotinic acetylcholine receptor agonist; non-narcotic analgesic
estrone Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.	6.95	1	17-oxo steroid; 3-hydroxy steroid; phenolic steroid; phenols	antineoplastic agent; bone density conservation agent; estrogen; human metabolite; mouse metabolite
serine Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.. serine : An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group.	2.11	1	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
2,3,4,6-tetrachlorophenol 2,3,4,6-tetrachlorophenol: RN given refers to parent cpd; see also record for tetrachlorophenol with locants for chloro groups not specified. 2,3,4,6-tetrachlorophenol : A tetrachlorophenol in which the chlorines are located at positions 2, 3, 4, and 6.	2.17	1	tetrachlorophenol	xenobiotic metabolite
uridine [no description available]	2.02	1	uridines	drug metabolite; fundamental metabolite; human metabolite
cytidine [no description available]	2.02	1	cytidines	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
chloroform Chloroform: A commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.. chloroform : A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.	2.05	1	chloromethanes; one-carbon compound	carcinogenic agent; central nervous system drug; inhalation anaesthetic; non-polar solvent; refrigerant
boranes Boranes: The collective name for the boron hydrides, which are analogous to the alkanes and silanes. Numerous boranes are known. Some have high calorific values and are used in high-energy fuels. (From Grant & Hackh's Chemical Dictionary, 5th ed). borane : The simplest borane, consisting of a single boron atom carrying three hydrogens.. boranes : The molecular hydrides of boron.	2.05	1	boranes; mononuclear parent hydride
propane Propane: A three carbon alkane with the formula H3CCH2CH3.	2.13	1	alkane; gas molecular entity	food propellant
boron trifluoride [no description available]	2.05	1	boron fluoride	NMR chemical shift reference compound
2-ethylpyridine 2-ethylpyridine: RN given refers to compound with locant	1.96	1
n-benzyl-n,n-dimethylamine [no description available]	2.25	1
acetic anhydride acetic anhydride: RN given refers to unlabeled cpd; structure. acetic anhydride : An acyclic carboxylic anhydride derived from acetic acid.	6.93	1	acyclic carboxylic anhydride	metabolite; reagent
propylene carbonate 4-methyl-1,3-dioxolan-2-one: structure in first source	7.13	1
4-methylpyridine 4-methylpyridine: structure in first source. 4-methylpyridine : A methylpyridine in which the methyl substituent is at position 4.	1.96	1	methylpyridine
3-methylpyridine 3-methylpyridine : A methylpyridine that is pyridine substituted by a methyl group at position 3.	1.96	1	methylpyridine
2-methylpiperidine 2-methylpiperidine: RN given refers to parent cpd without isomeric designation; structure given in first source	1.96	1	piperidines
2-picoline 2-picoline: structure in first source. 2-methylpyridine : A methylpyridine carrying a methyl substituent at position 2.	7.65	3	methylpyridine
piperidine [no description available]	1.96	1	azacycloalkane; piperidines; saturated organic heteromonocyclic parent; secondary amine	base; catalyst; human metabolite; non-polar solvent; plant metabolite; protic solvent; reagent
morpholine [no description available]	2.11	1	morpholines; saturated organic heteromonocyclic parent	NMR chemical shift reference compound
n-methylpyrrolidine N-methylpyrrolidine: RN given refers to parent cpd	1.96	1
2-hydroxypyridine hydroxypyridine : Any member of the class of pyridines with at least one hydroxy substituent.. pyridin-2-ol : A monohydroxypyridine that is pyridine substituted by a hydroxy group at position 2.	1.96	1	monohydroxypyridine	plant metabolite
pyrazines Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.	2.48	2	diazine; pyrazines	Daphnia magna metabolite
hydrazine diamine : Any polyamine that contains two amino groups.	2.02	1	azane; hydrazines	EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
coniine coniine: alkaloid isolated from Conium maculatum L.; properties as an analgesics, antineuralgic, & teratogen; RN given refers to parent cpd without isomeric designation; structure	1.96	1
3-aminopyridine [no description available]	1.96	1
alpha-aminopyridine alpha-aminopyridine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #485. aminopyridine : Compounds containing a pyridine skeleton substituted by one or more amine groups.	1.96	1
3-ethylpyridine 3-ethylpyridine: structure given in Merck	1.96	1	pyridines
n-methylpiperidine N-methylpiperidine: RN given refers to parent cpd	1.96	1
d-alpha tocopherol Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.	2.02	1	alpha-tocopherol	algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite
n-hydroxypiperidine [no description available]	1.96	1
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.25	1	metal allergen; nickel group element atom; platinum group metal atom
ruthenium Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.	2.08	1	iron group element atom; platinum group metal atom
nickel chloride nickel chloride: RN given refers to cpd with MF of Ni-Cl2. nickel dichloride : A compound of nickel and chloride in which the ratio of nickel (in the +2 oxidation state) to chloride is 1:2.	2.03	1	nickel coordination entity	calcium channel blocker; hapten
magnesium chlorate magnesium chlorate: RN given refers to parent cpd	2.02	1
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.37	2	benzenes; phenyl acetates
pyrrolidine [no description available]	1.96	1	azacycloalkane; pyrrolidines; saturated organic heteromonocyclic parent
alkenes [no description available]	2.45	2
silicon monoxide silanone: structure in first source	2.03	1	silicon oxide
bromosuccinimide Bromosuccinimide: A brominating agent that replaces hydrogen atoms in benzylic or allylic positions. It is used in the oxidation of secondary alcohols to ketones and in controlled low-energy brominations. (From Miall's Dictionary of Chemistry, 5th ed; Hawley's Condensed Chemical Dictionary, 12th ed,).	6.93	1	dicarboximide; organobromine compound; pyrrolidinone	reagent
3-methylpiperidine 3-methylpiperidine: structure in first source	1.96	1
nicotine (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.	1.96	1	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic
5-methylcytidine [no description available]	2.02	1	methylcytidine
chlorates Chlorates: Inorganic salts of chloric acid that contain the ClO3- ion.	2.02	1	chlorine oxoanion; monovalent inorganic anion
atropine tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.	1.96	1
maleic acid maleic acid: RN given refers to parent cpd(Z)-isomer which is maleic acid; all RR's given refer to (Z)-isomer; (E)-isomer is fumaric acid. maleic acid : A butenedioic acid in which the double bond has cis- (Z)-configuration.	2.55	2	butenedioic acid	algal metabolite; mouse metabolite; plant metabolite
ribothymidine ribothymidine : A methyluridine having a single methyl substituent at the 5-position on the uracil ring.	2.02	1	methyluridine	antigen; Escherichia coli metabolite; human metabolite
lobeline [no description available]	1.96	1
2,2,5,7,8-pentamethylchroman [no description available]	2.02	1
1,1-diphenyl-2-picrylhydrazyl 1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)	2.02	1
sodium iodate sodium iodate: RN given refers to iodic acid, Na salt	2.02	1	organic molecular entity
guanine [no description available]	2.05	1	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite

Condition	Indicated	Relationship Strength	Studies	Trials
Electrolytes Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	0	2.55	2	0

2,6-lutidine

Description

Cross-References

Synonyms (77)

Drug Classes (1)

Bioassays (5)

Research

Studies (25)

Market Indicators

Research Demand Index: 56.80

Study Types