1-methylguanosine profile

1-Methylguanosine (m1G) is a naturally occurring nucleoside, a derivative of guanosine with a methyl group attached to the N1 position of the guanine base. It is found in various biological molecules, including RNA, DNA, and tRNA. m1G plays a role in regulating gene expression and other cellular processes. In tRNA, m1G is critical for maintaining the correct structure and function of the molecule, influencing the efficiency of protein synthesis. The synthesis of m1G is catalyzed by specific methyltransferases, which transfer a methyl group from S-adenosyl methionine to the guanine base. Researchers study m1G to understand its roles in various cellular processes, including gene expression, RNA splicing, and protein synthesis. m1G has also been implicated in certain diseases, such as cancer. Understanding the function and regulation of m1G could lead to the development of new therapies for these diseases.'

1-methylguanosine : Guanosine substituted with a methyl group at position N-1. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	96373
CHEMBL ID	3246759
CHEBI ID	19062
SCHEMBL ID	62505
MeSH ID	M0074862

Synonym
2-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methyl-6,9-dihydro-1h-purin-6-one
2140-65-0
n1-methylguanosine
1-methylguanosine
2-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1-methyl-1,9-dihydro-6h-purin-6-one
CHEBI:19062 ,
2-amino-9-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methylpurin-6-one
nsc 70897
CHEMBL3246759 ,
SCHEMBL62505
1-methyl-guanosine
trmd protein
J-014033
CS-0061836
HY-113136
AKOS030573954
2-amino-9-((2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-methyl-1h-purin-6(9h)-one
bdbm50557953
Q27109106
2-azanyl-9-[(2r,3r,4s,5r)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-1-methyl-purin-6-one
DTXSID901316493
AS-77299

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
methylguanosine	Any guanosine carrying one or more methyl substituents.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID1136399	Activity of human erythrocyte purine nucleoside phosphorylase assessed as ribose relase at 5 umol after 30 mins by orcinol reaction relative to guanosine	1978	Journal of medicinal chemistry, Sep, Volume: 21, Issue:9	Stereoelectronic factors in the binding of substrate analogues and inhibitors to purine nucleoside phosphorylase isolated from human erythrocytes.
AID1710678	Metabolic stability in human intestinal S9 fraction assessed as parent compound remaining at 33 uM incubated for 2 hrs by LC/MS/MS analysis	2020	RSC medicinal chemistry, Dec-17, Volume: 11, Issue:12	A benzoxazole derivative as an inhibitor of anaerobic choline metabolism by human gut microbiota.
AID1710669	Inhibition of CutC in Escherichia coli MS 200-1 assessed as reduction in d9-TMA formation using d9-choline chloride as substrate incubated for 4 hrs under anaerobic condition by LC-MS-MS analysis	2020	RSC medicinal chemistry, Dec-17, Volume: 11, Issue:12	A benzoxazole derivative as an inhibitor of anaerobic choline metabolism by human gut microbiota.
AID1710670	Inhibition of N-terminal His6-tagged Desulfovibrio desulfuricans G20 CutC encoding 52 residues assessed as reduction in acetaldehyde using choline as substrate in presence of NADH-dependent yeast alcohol dehydrogenase by UV-Vis absorbance based assay	2020	RSC medicinal chemistry, Dec-17, Volume: 11, Issue:12	A benzoxazole derivative as an inhibitor of anaerobic choline metabolism by human gut microbiota.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	13 (36.11)	18.7374
1990's	10 (27.78)	18.2507
2000's	3 (8.33)	29.6817
2010's	8 (22.22)	24.3611
2020's	2 (5.56)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (2.63%)	6.00%
Case Studies	1 (2.63%)	4.05%
Observational	0 (0.00%)	0.25%
Other	36 (94.74%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	2.05	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
betaine aldehyde betaine aldehyde : A quaternary ammonium ion that is nitrogen substituted by three methyl groups and a 2-oxoethyl group. It is an intermediate in the metabolism of amino acids like glycine, serine and threonine.	2.25	1	quaternary ammonium ion	Aspergillus metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite
cytosine [no description available]	2.05	1	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
pyruvic acid Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed). pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.	2.11	1	2-oxo monocarboxylic acid	cofactor; fundamental metabolite
thiamine thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.	7.01	1	primary alcohol; vitamin B1	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
thymine [no description available]	2.05	1	pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	1.96	1	mitomycin	alkylating agent; antineoplastic agent
uridine [no description available]	2.66	3	uridines	drug metabolite; fundamental metabolite; human metabolite
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	1.98	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
cytidine [no description available]	2.47	2	cytidines	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
histidine Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.	1.97	1	amino acid zwitterion; histidine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
valine Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.	2.17	1	L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid; valine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
threonine Threonine: An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.. threonine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.	1.96	1	amino acid zwitterion; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid; threonine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
pseudouridine [no description available]	2.88	4	pseudouridines	fundamental metabolite
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	2.11	1	dihydrogen
nitrous acid Nitrous Acid: Nitrous acid (HNO2). A weak acid that exists only in solution. It can form water-soluble nitrites and stable esters. (From Merck Index, 11th ed)	1.99	1	nitrogen oxoacid
1-methyladenosine [no description available]	8.26	6	methyladenosine	human metabolite
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	8.6	9	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
xanthosine [no description available]	2.17	1	purines D-ribonucleoside; xanthosines	Escherichia coli metabolite; human metabolite; mouse metabolite
1-methylinosine 1-methylinosine : Inosine carrying a methyl substituent at position 1 on the hypoxanthine ring.	8.37	7	inosines	metabolite
6'-o-methylguanosine [no description available]	1.97	1
n-methyladenosine N-methyladenosine: is a inhibitor of cell differentiation. N(6)-methyladenosine : A methyladenosine compound with one methyl group attached to N(6) of the adenine nucleobase.	2	1	methyladenosine
wye [no description available]	6.97	1
3-methylthymine 3,5-dimethyluracil : A pyrimidone that is uracil with methyl group substituents at positions 3 and 5.	2.05	1	methylthymine; pyrimidone	metabolite
3-methylcytosine 3-methylcytosine : A pyrimidone that is cytosine in which the hydrogen attached to the nitrogen at position 3 is substituted by a methyl group.	2.05	1	aminopyrimidine; methylcytosine; pyrimidone	metabolite
3-nitrotyrosine 3-nitrotyrosine: RN given refers to parent cpd without isomeric designation. 3-nitrotyrosine : A nitrotyrosine comprising tyrosine having a nitro group at the 3-position on the phenyl ring.	1.98	1	2-nitrophenols; C-nitro compound; nitrotyrosine; non-proteinogenic alpha-amino acid
5'-methylthioadenosine 5'-methylthioadenosine: structure. 5'-S-methyl-5'-thioadenosine : Adenosine with the hydroxy group at C-5' substituted with a methylthio (methylsulfanyl) group.	1.99	1	thioadenosine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
n(6),n(6)-dimethyladenosine N(6),N(6)-dimethyladenosine : A methyladenosine compound with two methyl groups attached to N(6) of the adenine nucleobase.	2	1	hydrocarbyladenosine
ribothymidine ribothymidine : A methyluridine having a single methyl substituent at the 5-position on the uracil ring.	1.96	1	methyluridine	antigen; Escherichia coli metabolite; human metabolite
formycin [no description available]	1.95	1	formycin	antineoplastic agent
2'-deoxyoxanosine 2'-deoxyoxanosine: structure given in first source	1.99	1
4-demethylwyosine 4-demethylwyosine: structure in first source. 4-demethylwyosine : A nucleoside analogue having 6-methyl-3,5-dihydro-9H-imidazo[1,2-a]purin-9-one as the modified nucleobase.	2.11	1	nucleoside analogue
3-methylcytidine [no description available]	2.31	1	methylcytidine
anticodon Anticodon: The sequential set of three nucleotides in TRANSFER RNA that interacts with its complement in MESSENGER RNA, the CODON, during translation in the ribosome.	8.37	7
s-adenosylmethionine (R)-S-adenosyl-L-methionine : An S-adenosyl-L-methionine that has R-configuration.. S-adenosyl-L-methionine zwitterion : A zwitterionic tautomer of S-adenosyl-L-methionine arising from shift of the proton from the carboxy group to the amino group.. (R)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has R-configuration; major species at pH 7.3.. (S)-S-adenosyl-L-methionine zwitterion : An S-adenosyl-L-methionine zwitterion that has S-configuration; major species at pH 7.3.. S-adenosyl-L-methionine : A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine.	2.11	1	organic cation; sulfonium compound	coenzyme; cofactor; human metabolite; micronutrient; Mycoplasma genitalium metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
3-methyluridine 3-methyluridine: isolated from normal human urine & is a minor constituent of tRNA form yeast, rat and human liver; structure	2.38	2
deoxyguanosine [no description available]	2.66	3	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanosine monophosphate Guanosine Monophosphate: A guanine nucleotide containing one phosphate group esterified to the sugar moiety and found widely in nature.. guanosine 5'-monophosphate : A purine ribonucleoside 5'-monophosphate having guanine as the nucleobase.	1.95	1	guanosine 5'-phosphate; purine ribonucleoside 5'-monophosphate	biomarker; Escherichia coli metabolite; metabolite; mouse metabolite
guanosine triphosphate Guanosine Triphosphate: Guanosine 5'-(tetrahydrogen triphosphate). A guanine nucleotide containing three phosphate groups esterified to the sugar moiety.	1.99	1	guanosine 5'-phosphate; purine ribonucleoside 5'-triphosphate	Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor
guanine [no description available]	2.36	2	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
guanosine ribonucleoside : Any nucleoside where the sugar component is D-ribose.	5.98	35	guanosines; purines D-ribonucleoside	fundamental metabolite
hypoxanthine [no description available]	1.95	1	nucleobase analogue; oxopurine; purine nucleobase	fundamental metabolite
inosine [no description available]	8.48	8	inosines; purines D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
1-methyladenine 1-methyladenine : Adenine substituted with a methyl group at position N-1.	2.05	1
9-methylguanine 9-methylguanine: structure in first source	1.95	1
azaguanine Azaguanine: One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.. 8-azaguanine : A triazolopyrimidine that consists of 3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing amino and oxo substituents at positions 5 and 7 respectively.	1.95	1	nucleobase analogue; triazolopyrimidines	antimetabolite; antineoplastic agent; EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor
2'-o-methylguanosine 2'-O-methylguanosine : Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.	2.38	2	methylguanosine	metabolite
8-azahypoxanthine 8-azahypoxanthine: an antimalarial that inhibits hypoxanthine-guanine-xanthine phosphoribosyltransferase; structure. 8-azahypoxanthine : A triazolopyrimidine that consists of 1,4-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidine bearing an oxo substituent at position 7.	1.95	1	nucleobase analogue; triazolopyrimidines	antimalarial; EC 2.4.2.8 (hypoxanthine phosphoribosyltransferase) inhibitor
7-methylguanosine 7-methylguanosine : A positively charged methylguanosine in which a single methyl substituent is located at position 7.	2.88	4	methylguanosine; organic cation	metabolite
8-bromoguanosine [no description available]	1.95	1	purine nucleoside
n(2),n(2)-dimethylguanosine N(2),N(2)-dimethylguanosine: elevated levels in urine of cancer patients. N(2),N(2)-dimethylguanosine : A guanosine where the hydrogens of the amine group at C-2 are substituted by methyl groups.	3.24	6	methylguanosine	human metabolite
8-aminoguanosine [no description available]	1.95	1
3'-o-methylguanosine 3'-O-methylguanosine : Guanosine with the hydrogen on the hydroxyl at position C-3' substituted with a methyl group.	1.97	1	methylguanosine	metabolite

Condition	Relationship Strength	Studies
Diabetes Mellitus, Adult-Onset [description not available]	2.17	1
Diabetic Glomerulosclerosis [description not available]	2.17	1
Albuminuria The presence of albumin in the urine, an indicator of KIDNEY DISEASES.	2.17	1
Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.	2.17	1
Diabetic Nephropathies KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.	2.17	1
Granulocytic Leukemia [description not available]	1.96	1
Experimental Lung Inflammation Inflammation of any part, segment or lobe, of the lung parenchyma.	1.96	1
Leukemia, Myeloid Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.	1.96	1
Pneumonia Infection of the lung often accompanied by inflammation.	1.96	1
Urinary Tract Infections Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	1.96	1
Leukemia, Lymphocytic [description not available]	1.96	1
Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.	1.96	1
Anorexia Nervosa An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)	1.96	1
Breast Cancer [description not available]	1.99	1
Cancer of Mouth [description not available]	1.99	1
Breast Neoplasms Tumors or cancer of the human BREAST.	1.99	1
Mouth Neoplasms Tumors or cancer of the MOUTH.	1.99	1
Bladder Cancer [description not available]	1.96	1
Adenocarcinoma Of Kidney [description not available]	1.96	1
Female Genital Neoplasms [description not available]	1.96	1
Cancer of Kidney [description not available]	1.96	1
Genito-urinary Cancer [description not available]	1.96	1
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	1.96	1
Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.	1.96	1
Genital Neoplasms, Female Tumor or cancer of the female reproductive tract (GENITALIA, FEMALE).	1.96	1
Kidney Neoplasms Tumors or cancers of the KIDNEY.	1.96	1
Urogenital Neoplasms Tumors or cancer of the UROGENITAL SYSTEM in either the male or the female.	1.96	1

1-methylguanosine

Description

Cross-References

Synonyms (22)

Roles (1)

Drug Classes (1)

Protein Targets (1)

Inhibition Measurements

Bioassays (4)

Research

Studies (36)

Market Indicators

Research Demand Index: 22.63

Study Types