2'-o-methylcytidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID Source	ID
PubMed CID	150971
CHEMBL ID	176605
CHEBI ID	19228
SCHEMBL ID	64632
MeSH ID	M0148260

Synonyms (32)

Synonym
2'-o-methyl cytidine
4-amino-1-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxy-tetrahydrofuran-2-yl]pyrimidin-2-one
4-amino-1-((2r,3r,4s,5r)-4-hydroxy-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl)-1h-pyrimidin-2-one
2'-o-methyl-cytidine
2'-o-methylcytidine ,
o(2')-methylcytidine
2140-72-9
CHEBI:19228 ,
4-amino-1-[(2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidin-2-one
CHEMBL176605
unii-5xd9ih2g27
5xd9ih2g27 ,
cytidine, 2'-o-methyl-
4-amino-1-((2r,3r,4r,5r)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidin-2(1h)-one
AKOS015896935
AKOS015850975
BRD-K23276845-001-01-1
HG1325
SCHEMBL64632
o-2-methylcytidine
mfcd11519076
DS-14587
4-imino-1-(2-o-methylpentofuranosyl)-1,4-dihydropyrimidin-2-ol
DTXSID50943958
Q15632793
ZB1481
CS-W012550
HY-W011834
PD143476
BP-58836
o2'-methylycytidine
4-azanyl-1-[(2r,3r,4r,5r)-5-(hydroxymethyl)-3-methoxy-4-oxidanyl-oxolan-2-yl]pyrimidin-2-one

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
methylcytidine	Any member of the class of cytidines that is cytidine substituted by at least one methyl group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (10)

Assay ID	Title	Year	Journal	Article
AID246380	Effective concentration against hepatitis C virus RNA replication in a subgenomic bicistronic replicon in HBI10A cells	2005	Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4	Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID658631	Inhibition of Hepatitis C virus NS5B RNA-dependent RNA polymerase	2012	Bioorganic & medicinal chemistry, May-15, Volume: 20, Issue:10	Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations.
AID250331	Average intracellular Metabolism was measured in human Huh-7 cells after 23 hr of incubation	2005	Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4	Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID250347	Average intracellular Metabolism was measured in human HBI10A cells after 23 hr of incubation	2005	Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4	Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID326208	Antiviral activity against Hepatitis C virus infected in human Huh7 AVA5 cells by replicon assay	2008	Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5	Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine.
AID245967	Cytotoxic concentration of compound in human HBI10A cells infected with hepatitis C virus in MTS assay	2005	Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4	Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID250318	Average intracellular Metabolism was measured in human Huh-7 cells after 3 h of incubation	2005	Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4	Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID326209	Cytotoxicity against human Huh7 AVA5 cells	2008	Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5	Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine.
AID250330	Average intracellular Metabolism was measured in human HBI10A cells after 3 h of incubation	2005	Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4	Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
AID248115	Inhibitory concentration against hepatitis C virus NS5B-mediated RNA synthesis in HBI10A cells	2005	Journal of medicinal chemistry, Feb-24, Volume: 48, Issue:4	Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (6.67)	18.7374
1990's	3 (20.00)	18.2507
2000's	4 (26.67)	29.6817
2010's	7 (46.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	23.78 (24.57)
Research Supply Index	2.83 (2.92)
Research Growth Index	4.97 (4.65)
Search Engine Demand Index	23.28 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (23.78)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (6.25%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (93.75%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
thymidine [no description available]	2.1	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
uridine [no description available]	3.11	5	uridines	drug metabolite; fundamental metabolite; human metabolite
cytidine monophosphate Cytidine Monophosphate: Cytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.. cytidine 5'-monophosphate : A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.	2.02	1	cytidine 5'-phosphate; pyrimidine ribonucleoside 5'-monophosphate	Escherichia coli metabolite; human metabolite; mouse metabolite
cytidine [no description available]	3.98	13	cytidines	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
cytidine triphosphate Cytidine Triphosphate: Cytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety.	2.01	1	cytidine 5'-phosphate; pyrimidine ribonucleoside 5'-triphosphate	Escherichia coli metabolite; mouse metabolite
osmium Osmium: A very hard, gray, toxic, and nearly infusible metal element, atomic number 76, atomic weight 190.2, symbol Os.	2.17	1	iron group element atom; platinum group metal atom
zalcitabine Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.	2.02	1	pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
1-methyladenosine [no description available]	2	1	methyladenosine	human metabolite
adenosine quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit	2.96	4	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent
1-methylinosine 1-methylinosine : Inosine carrying a methyl substituent at position 1 on the hypoxanthine ring.	2	1	inosines	metabolite
5-methylcytidine [no description available]	2.72	3	methylcytidine
n-methyladenosine N-methyladenosine: is a inhibitor of cell differentiation. N(6)-methyladenosine : A methyladenosine compound with one methyl group attached to N(6) of the adenine nucleobase.	2.21	1	methyladenosine
2'-o-methyluridine [no description available]	2.93	4	methyluridine
2'-o-methyladenosine cordysinin B : A member of the class of adenosines that is adenosine in which the hydroxy group at position 2' is replaced by a methoxy group. It has been isolated from the mycelia of Cordyceps sinensis.	2.44	2	adenosines; ether	fungal metabolite
n-acetylcytidine N(4)-acetylcytidine : Cytidine in which one of the exocyclic amino hydrogens is substituted by an acetyl group.	2.21	1	acetamides; cytidines; secondary carboxamide	metabolite
5-formylcytidine 5-formylcytidine: found at the first position of the anticodon of methionine tRNA from bovine liver mitochondria; structure given in first source	2.21	1
3'-deoxycytidine [no description available]	3.55	2
ribothymidine ribothymidine : A methyluridine having a single methyl substituent at the 5-position on the uracil ring.	2.17	1	methyluridine	antigen; Escherichia coli metabolite; human metabolite
4'-azidocytidine 4'-azidocytidine: antiviral; structure in first source	3.17	1	N-glycosyl compound
2'-c-methyladenosine 2'-C-methyladenosine: antiviral	3.17	1
hcv 796 HCV 796: inhibits HCV RdRp; structure in first source	3.17	1
oligonucleotides [no description available]	2.1	1
anticodon Anticodon: The sequential set of three nucleotides in TRANSFER RNA that interacts with its complement in MESSENGER RNA, the CODON, during translation in the ribosome.	2	1
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.	2.04	1	2-aminopurines; oxopurine	antimetabolite; antiviral drug
guanosine ribonucleoside : Any nucleoside where the sugar component is D-ribose.	2.76	3	guanosines; purines D-ribonucleoside	fundamental metabolite
inosine [no description available]	2	1	inosines; purines D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
ganciclovir [no description available]	2.04	1	2-aminopurines; oxopurine	antiinfective agent; antiviral drug
2'-o-methylguanosine 2'-O-methylguanosine : Guanosine with the hydrogen on the hydroxyl at position C-2' substituted with a methyl group.	4.25	5	methylguanosine	metabolite
cyclopropavir cyclopropavir: cyclopropavir is the (Z)-isomer; has antiviral activity; structure in first source	2.04	1
3-deoxyguanosine 3'-deoxyguanosine : A 3'-deoxyribonucleoside having guanine as the nucleobase.	3.55	2	3'-deoxyribonucleoside; guanosines	EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor
8-methylguanosine 8-methylguanosine: structure in first source	2.21	1

Condition	Relationship Strength	Studies
Abnormalities, Autosome [description not available]	2.02	1
ALS - Amyotrophic Lateral Sclerosis [description not available]	2.21	1
Amyotrophic Lateral Sclerosis A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)	2.21	1
Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted [description not available]	2.01	1
Hepatitis C INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.	2.01	1

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