1-methylpseudouridine

Description

1-methylpseudouridine (m1Ψ) is a modified nucleoside found in various RNA molecules, including ribosomal RNA (rRNA) and transfer RNA (tRNA). It is a derivative of pseudouridine, where a methyl group is attached to the N1 position of the pseudouridine base. m1Ψ is known to play significant roles in RNA structure, stability, and function. Studies have shown that m1Ψ can enhance the stability of RNA molecules by increasing their resistance to degradation. This is because the methyl group can contribute to stacking interactions within the RNA structure, making the molecule more rigid and less susceptible to enzymatic breakdown. Additionally, m1Ψ has been implicated in influencing RNA folding and the formation of specific RNA structures, such as stem-loop structures. This, in turn, can affect the interactions of RNA molecules with other cellular components, including proteins and other RNA molecules. The presence of m1Ψ in rRNA has been linked to proper ribosome assembly and function. It can affect the efficiency of translation, the process of protein synthesis. Moreover, m1Ψ has been shown to be involved in regulating the activity of certain enzymes that interact with RNA. These enzymes include RNA-dependent RNA polymerases, which play a crucial role in the replication of viral RNA. The synthesis of m1Ψ is catalyzed by specific enzymes called methyltransferases. These enzymes specifically recognize and methylate pseudouridine residues within RNA molecules. The process typically involves the transfer of a methyl group from a donor molecule, such as S-adenosyl methionine (SAM), to the N1 position of the pseudouridine base. The study of m1Ψ is important for understanding the complex mechanisms underlying RNA biology and the roles of RNA modifications in cellular processes. Research on m1Ψ is ongoing, aiming to elucidate its specific functions in different RNA molecules, its potential therapeutic applications, and its implications for human health.'

1-methylpseudouridine: metabolite from culture filtrates of Streptomyces platensis; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

1-methylpseudouridine : A methylpseudouridine in which the methyl group is located at position N-1 on the uracil ring. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]