ribothymidine and Leukemia-P388

ribothymidine has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for ribothymidine and Leukemia-P388

ArticleYear
Enhancement of antitumor activity of 5-fluorouracil by ribothymidine.
    Journal of pharmacobio-dynamics, 1986, Volume: 9, Issue:8

    The antitumor activity of 5-fluorouracil (5-FU) in combination with ribothymidine was examined on some experimental murine carcinomas. The antitumor activity of 5-FU against Ehrlich ascites carcinoma was markedly enhanced by intraperitoneal coadministration of ribothymidine. The enhancement of the antitumor activity of 5-FU by ribothymidine was also observed against Ehrlich solid carcinoma both by oral and intraperitoneal administrations. Furthermore, the combination therapy of 5-FU and ribothymidine was effective even on 5-FU-resistant P388 leukemia. These results suggest that the combination of 5-FU and ribothymidine may be more effective than 5-FU monotherapy in clinical use.

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Drug Synergism; Fluorouracil; Leukemia P388; Male; Mice; Mice, Inbred Strains; Uridine

1986