Page last updated: 2024-09-25

ici 169369

Description

2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline: structure & RN given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID122265
CHEMBL ID1191534
SCHEMBL ID2640021
MeSH IDM0153560

Synonyms (30)

Synonym
ici-169369
gtpl273
ici 169369
PDSP1_001421
PDSP2_001405
2-detpq
ethanamine, n,n-dimethyl-2-((3-phenyl-2-quinolinyl)thio)-
2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline
ici-169,369
L001066
n,n-dimethyl-2-(3-phenylquinolin-2-yl)sulfanylethanamine
CHEMBL1191534
cas_122265
bdbm84945
nsc_122265
ici 169,369
ethanamine, n,n-dimethyl-2-[(3-phenyl-2-quinolinyl)thio]-
4ct4cs5ba7 ,
unii-4ct4cs5ba7
85273-95-6
SCHEMBL2640021
DTXSID40234468
2-(2-dimethylaminoethylthio)-3-phenylquinoline
AKOS030595293
n,n-dimethyl-2-((3-phenyl-2-quinolinyl)thio)ethanamine
zm-169369
ici-169369 free base
Q27078026
n,n-dimethyl-2-((3-phenylquinolin-2-yl)thio)ethanamine
F87712

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1345170Human 5-HT6 receptor (5-Hydroxytryptamine receptors)1996Journal of neurochemistry, Jan, Volume: 66, Issue:1
Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (33.33)18.7374
1990's18 (60.00)18.2507
2000's2 (6.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (12.90%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (87.10%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Long-term Use (3)

ArticleYear
Effects of ritanserin on haloperidol-induced dopamine (D2) receptor up-regulation in the rat.
Neuroscience letters, Aug-08, Volume: 231, Issue: 2
1997
Effects of chronic treatment with two selective 5-HT2 antagonists on sleep in the rat.
Pharmacology, biochemistry, and behavior, Volume: 44, Issue: 4
1993
Effects of ICI 169,369, a selective serotonin2 antagonist, in electrophysiological tests predictive of antipsychotic activity.
The Journal of pharmacology and experimental therapeutics, Volume: 249, Issue: 3
1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (2)

ArticleYear
Does a selective 5-hydroxytryptamine antagonist (ICI 169, 369) lower blood pressure in hypertensive patients?
British journal of clinical pharmacology, Volume: 27, Issue: 4
1989
Pharmacological studies in vivo with ICI 169,369, a chemically novel 5-HT2/5-HT1C receptor antagonist.
European journal of pharmacology, May-16, Volume: 180, Issue: 2-3
1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

ArticleYear
The effects of a 5-HT2 receptor antagonist (ICI 169,369) on changes in waking EEG, pupillary responses and state of arousal in human volunteers.
British journal of clinical pharmacology, Volume: 32, Issue: 4
1991
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]