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2-aminoadenosine and adenosine

2-aminoadenosine has been researched along with adenosine in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19909 (33.33)18.7374
1990's4 (14.81)18.2507
2000's6 (22.22)29.6817
2010's8 (29.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Montgomery, JA; Secrist, JA; Shortnacy, AT2
Bressi, JC; Buckner, FS; Choe, J; Gelb, MH; Hol, WG; Hough, MT; Van Voorhis, WC; Verlinde, CL1
Abel-Santos, E; Alvarez, Z; Lee, K1
Bao, H; Du, J; Furman, PA; Mosley, RT; Murakami, E; Sofia, MJ1
An, SH; Au, A; Garza, G; Land, KM; Shokar, A; Tong, E; Wnuk, SF; Zayas, J1
Carlson, EE; Goswami, M; Wilke, KE1
Blencowe, BJ; Iribarren, AM; Lamm, GM; Lamond, AI; Ryder, U; Sproat, BS1
Cerný, J; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Sedivá, K; Veselý, J; Vlach, J; Votruba, I1
Contardo, N; deJesus, R; Dotson, R; Francis, JE; Ghai, GR; Hutchison, AJ; Moskal, MA; Rovinski, SL; Webb, RL; Yokoyama, R1
Cory, JG; Weckbecker, G1
Altona, C; Mellema, JR; Rinkel, LJ; van Boom, JH; van der Marel, GA1
Kollman, PA; Rao, SN1
Grzeskowiak, K; Orgel, LE; Webb, TR1
Bajaj, S; Hirschhorn, R; Insel, J; Quagliata, F; Silber, R1
Miles, HT; Roy, KB1
Azhikina, T; Ermolayeva, O; Myasnikov, V; Potapov, V; Sverdlov, E; Veselovskaya, S1
Hassan, AE; Montgomery, JA; Secrist, JA; Shortnacy-Fowler, AT1
Dorris, D; Mazumder, A; Nguyen, A; Zhao, C1
KORNBERG, A; PRICER, WE1
Kore, AR; Parmar, G; Reddy, S1
Seela, F; Xu, K1
Ravikumar, VT; Ross, BS; Springer, RH1
Leonard, P; Pujari, SS; Seela, F1
Bilbao, N; Camacho-García, J; González-Rodríguez, D; López-Pérez, AM; Montoro-García, C; Romero-Pérez, S1
Langkjær, N; Pasternak, A; Wengel, J1
Amblard, F; Amiralaei, S; Cho, JH; Coats, SJ; Domaoal, RA; Ehteshami, M; Khalil, A; Lee, SS; Lin, B; Lu, X; Ozturk, T; Schinazi, RF; Shelton, JR; Stanton, RA; Suesserman, JE; Tao, S; Whitaker, T; Zhang, H; Zhou, L1

Other Studies

27 other study(ies) available for 2-aminoadenosine and adenosine

ArticleYear
2-Fluoroformycin and 2-aminoformycin. Synthesis and biological activity.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:11

    Topics: Adenosine; Adenosine Deaminase; Animals; Antibiotics, Antineoplastic; Formycins; Kinetics; Leukemia L1210; Nucleotides; Phosphates; Substrate Specificity

1985
Synthesis and biological evaluation of 2-fluoro-8-azaadenosine and related compounds.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:10

    Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line; Drug Evaluation, Preclinical; Humans; Indicators and Reagents; Laryngeal Neoplasms; Leukemia P388; Leukemia, Experimental; Magnetic Resonance Spectroscopy; Mice; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

1983
Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.
    Journal of medicinal chemistry, 2000, Nov-02, Volume: 43, Issue:22

    Topics: Adenosine; Animals; Combinatorial Chemistry Techniques; Crystallography, X-Ray; Enzyme Inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenases; Glycerolphosphate Dehydrogenase; Models, Molecular; Molecular Conformation; Phosphoglycerate Kinase; Protein Binding; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi

2000
Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12

    Topics: Alanine; Animals; Bacillus anthracis; Cell Line; Guanosine; Macrophages; Mice; Spores, Bacterial; Structure-Activity Relationship; Thionucleosides

2010
Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates.
    Journal of medicinal chemistry, 2011, Aug-25, Volume: 54, Issue:16

    Topics: 2-Aminopurine; Adenosine Monophosphate; Amino Acid Sequence; Aminohydrolases; Biocatalysis; Cell Line, Tumor; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Humans; Hydrolysis; Isoenzymes; Kinetics; Molecular Sequence Data; Molecular Structure; Molecular Weight; Nucleoside Deaminases; Phosphorylation; Purines; Recombinant Proteins; Sequence Analysis, Protein; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Zinc

2011
S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,D-arabinofuranosyl)adenine.
    Bioorganic & medicinal chemistry letters, 2012, Jun-15, Volume: 22, Issue:12

    Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiprotozoal Agents; Cell Culture Techniques; Cell Survival; CHO Cells; Cricetinae; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Metronidazole; Protozoan Proteins; Structure-Activity Relationship; Trichomonas vaginalis; Uridine

2012
Rational Design of Selective Adenine-Based Scaffolds for Inactivation of Bacterial Histidine Kinases.
    Journal of medicinal chemistry, 2017, 10-12, Volume: 60, Issue:19

    Topics: Adenine; Adenosine Triphosphate; Anti-Bacterial Agents; Aspartic Acid; Bacteria; Drug Design; Histidine Kinase; HSP90 Heat-Shock Proteins; Models, Molecular; Molecular Docking Simulation; Structure-Activity Relationship

2017
Antisense probes containing 2-aminoadenosine allow efficient depletion of U5 snRNP from HeLa splicing extracts.
    Nucleic acids research, 1991, Jun-25, Volume: 19, Issue:12

    Topics: Adenosine; Base Sequence; DNA; Electrophoresis, Polyacrylamide Gel; Endoribonucleases; HeLa Cells; Humans; Hydrogen Bonding; Molecular Sequence Data; Nucleic Acid Conformation; Ribonuclease H; Ribonucleoproteins; Ribonucleoproteins, Small Nuclear; RNA Precursors; RNA Probes; RNA Splicing; RNA, Antisense

1991
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro.
    Antiviral research, 1990, Volume: 13, Issue:6

    Topics: Adenine; Adenosine; Antiviral Agents; Cidofovir; Cytosine; DNA Viruses; Guanine; In Vitro Techniques; Nucleic Acid Synthesis Inhibitors; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purine-Nucleoside Phosphorylase; Reverse Transcriptase Inhibitors; Ribonucleotide Reductases; Structure-Activity Relationship; Tubercidin

1990
Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:8

    Topics: Adenosine; Alkylation; Animals; Antihypertensive Agents; Blood Pressure; Chemical Phenomena; Chemistry; Cyclohexanes; Heart Rate; Hypertension; Male; Molecular Structure; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Purinergic

1991
Metabolic activation of 2,6-diaminopurine and 2,6-diaminopurine-2'-deoxyriboside to antitumor agents.
    Advances in enzyme regulation, 1989, Volume: 28

    Topics: Adenosine; Animals; Antineoplastic Agents; Biotransformation; Cell Aggregation; Cell Cycle; Cell Division; Chromatography, High Pressure Liquid; Deoxyadenosines; Kinetics; Leukemia L1210; Mice; Ribonucleotides

1989
Influence of 2-aminoadenosine, A', on the conformational behaviour of d(T-A'-T-A'). A one-dimensional proton NMR study at 300 MHz and 500 MHz.
    European journal of biochemistry, 1986, Jan-15, Volume: 154, Issue:2

    Topics: Adenosine; Computers; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protons; Temperature; Thermodynamics

1986
Hydrogen-bonding preferences in 2,6-diaminopurine: uracil (thymine) and 8-methyl adenine:uracil (thymine) complexes.
    Biopolymers, 1986, Volume: 25, Issue:2

    Topics: Adenine; Adenosine; Hydrogen Bonding; Nucleic Acid Conformation; Structure-Activity Relationship; Thymine; Uracil

1986
Template-directed synthesis with 2-aminoadenosine.
    Journal of molecular evolution, 1984, Volume: 21, Issue:1

    Topics: Adenosine; Biological Evolution; Oligonucleotides; Poly A; Poly C; Poly U

1984
Adenosine and adenosine analogues are more toxic to chronic lymphocytic leukemia than to normal lymphocytes.
    Blood, 1983, Volume: 62, Issue:1

    Topics: Adenosine; B-Lymphocytes; Deoxyadenosines; Humans; Leucine; Leukemia, Lymphoid; Phytohemagglutinins; Thymidine; Vidarabine

1983
Binding isotherms of nucleosides and polynucleotides measured by continuous ultrafiltration at constant volume: a rapid and precise technique.
    Biochemistry, 1982, Jan-05, Volume: 21, Issue:1

    Topics: Adenosine; Dialysis; Hydrogen Bonding; Poly U; Temperature; Thermodynamics; Ultrafiltration

1982
Strings of contiguous modified pentanucleotides with increased DNA-binding affinity can be used for DNA sequencing by primer walking.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Dec-15, Volume: 90, Issue:24

    Topics: Adenosine; Amides; Base Sequence; Cytidine; DNA; DNA Primers; Indicators and Reagents; Molecular Sequence Data; Oligodeoxyribonucleotides; Phosphoric Acids; Structure-Activity Relationship

1993
A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy.
    Nucleosides, nucleotides & nucleic acids, 2000, Volume: 19, Issue:3

    Topics: Adenosine; Deoxyadenosines; Genetic Therapy; Prodrugs

2000
Quantitative assessment of the use of modified nucleoside triphosphates in expression profiling: differential effects on signal intensities and impacts on expression ratios.
    BMC biotechnology, 2002, Jul-31, Volume: 2

    Topics: Adenosine; Gene Expression Profiling; Nucleic Acid Hybridization; Nucleotides; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; RNA; RNA, Complementary

2002
Enzymatic phosphorylation of adenosine and 2,6-diaminopurine riboside.
    The Journal of biological chemistry, 1951, Volume: 193, Issue:2

    Topics: Adenosine; Phosphorylation; Purines

1951
An efficient process for synthesis of 2'-O-methyl and 3'-O-methyl guanosine from 2-aminoadenosine using diazomethane and the catalyst stannous chloride.
    Nucleosides, nucleotides & nucleic acids, 2006, Volume: 25, Issue:3

    Topics: Adenosine; Chromatography, High Pressure Liquid; Diazomethane; Guanosine; Tin Compounds

2006
Pyrazolo[3,4-d]pyrimidine ribonucleosides related to 2-aminoadenosine and isoguanosine: synthesis, deamination and tautomerism.
    Organic & biomolecular chemistry, 2007, Sep-21, Volume: 5, Issue:18

    Topics: Adenosine; Adenosine Deaminase; Deamination; Guanosine; Magnetic Resonance Spectroscopy; Pyrazoles; Pyrimidine Nucleosides; Pyrimidines; Spectrophotometry, Ultraviolet; Stereoisomerism

2007
An efficient and scalable synthesis of 2,6-diaminopurine riboside.
    Nucleosides, nucleotides & nucleic acids, 2008, Volume: 27, Issue:1

    Topics: Adenosine; Molecular Structure; Oligoribonucleotides

2008
Oligonucleotides with "clickable" sugar residues: synthesis, duplex stability, and terminal versus central interstrand cross-linking of 2'-O-propargylated 2-aminoadenosine with a bifunctional azide.
    The Journal of organic chemistry, 2014, May-16, Volume: 79, Issue:10

    Topics: Adenosine; Azides; Catalysis; Click Chemistry; Copper; Cross-Linking Reagents; DNA; Ligation; Magnetic Resonance Spectroscopy; Molecular Structure; Oligonucleotides; Pargyline

2014
Synthesis and complementary self-association of novel lipophilic π-conjugated nucleoside oligomers.
    Organic & biomolecular chemistry, 2015, Apr-21, Volume: 13, Issue:15

    Topics: Adenosine; Cytosine; Dimerization; Guanosine; Hydrogen Bonding; Nucleosides; Polymers; Uridine

2015
Watson-Crick hydrogen bonding of unlocked nucleic acids.
    Bioorganic & medicinal chemistry letters, 2015, Nov-15, Volume: 25, Issue:22

    Topics: Adenosine; Base Pairing; Base Sequence; Hydrogen Bonding; Inosine; Nucleic Acid Conformation; Oligoribonucleotides; RNA; RNA Stability; Thermodynamics

2015
Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:8

    Topics: Adenosine; Antiviral Agents; Cell Line; DNA-Directed RNA Polymerases; Guanosine Monophosphate; Hepacivirus; Hepatitis C; Humans; Prodrugs; Ribonucleosides; RNA; RNA, Mitochondrial; RNA, Viral; Sofosbuvir; Transcription, Genetic; Viral Nonstructural Proteins; Virus Replication

2016