Compounds > mannopine
Page last updated: 2024-11-07

mannopine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Mannopine is a rare sugar derivative found in the bacterium Agrobacterium tumefaciens. It is synthesized by the bacterium as a byproduct of its infection of plants, specifically during the formation of crown gall tumors. The synthesis of mannopine involves the condensation of mannose and pyruvate, catalyzed by the enzyme mannopine synthase. This compound acts as a growth regulator in plants, influencing cell division and proliferation. It also serves as a specific signal molecule for Agrobacterium, allowing the bacterium to recognize and infect susceptible plants. The study of mannopine is crucial in understanding the mechanisms of plant-bacterial interactions, particularly the role of Agrobacterium in tumor formation and the development of plant genetic engineering techniques.'

mannopine: mannityl opine analog; RN given refers to (S)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

mannopine : A hexitol derivative that is D-mannitol in which the hydroxy group at position 1 is replaced by the alpha-amino group of L-glutamine. It is produced in crown gall tumours induced in a wide range of dicotyledenous plants by Agrobacterium tumefaciens. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID121864
CHEBI ID80662
SCHEMBL ID23388718
MeSH IDM0122656

Synonyms (12)

Synonym
87084-52-4
mannopine
(2s)-5-amino-5-oxo-2-[[(2r,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]amino]pentanoic acid
d-mannitol, 1-((4-amino-1-carboxy-4-oxobutyl)amino)-1-deoxy-, (s)-
n(alpha)-(1-d-mannityl)-l-glutamine
n(2)-(1'-deoxy-d-mannitol-1'-yl)-l-glutamine
CHEBI:80662
1-{[(1s)-4-amino-1-carboxy-4-oxobutyl]amino}-1-deoxy-d-mannitol
DTXSID60236121
mo0 ,
Q27149704
SCHEMBL23388718
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (6)

ClassDescription
hexitol derivativeAn alditol derivative that is formally obtained from a hexitol.
dicarboxylic acid monoamide
secondary amino compoundA compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups.
amino acid opineAny opine whose structure is based on the condensation of an amino acid with a carbohydrate or a keto-acid.
non-proteinogenic L-alpha-amino acidAny L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.
L-glutamine derivativeA proteinogenic amino acid derivative resulting from reaction of L-glutamine at the amino group, the carboxy group, or the carboxamide, or from the replacement of any hydrogen of L-glutamine by a heteroatom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (39)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (15.38)18.7374
1990's16 (41.03)18.2507
2000's11 (28.21)29.6817
2010's4 (10.26)24.3611
2020's2 (5.13)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 16.17

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index16.17 (24.57)
Research Supply Index3.71 (2.92)
Research Growth Index4.70 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (16.17)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other40 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
succinic acid
Succinic Acid: A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851). succinic acid : An alpha,omega-dicarboxylic acid resulting from the formal oxidation of each of the terminal methyl groups of butane to the corresponding carboxy group. It is an intermediate metabolite in the citric acid cycle.		1.9810alpha,omega-dicarboxylic acid;
C4-dicarboxylic acid		anti-ulcer drug;
fundamental metabolite;
micronutrient;
nutraceutical;
radiation protective agent
glutamine
Glutamine: A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.. L-glutamine : An optically active form of glutamine having L-configuration.. glutamine : An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4.		2.420amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
mannitol
[no description available]		4.99390mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		3.580arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
homoserine
homoserine : An alpha-amino acid that is glycine substituted at the alpha-position by a 2-hydroxyethyl group.. L-homoserine : The L-enantiomer of homoserine.		210amino acid zwitterion;
homoserine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
Saccharomyces cerevisiae metabolite
mannose
mannopyranose : The pyranose form of mannose.		1.9710D-aldohexose;
D-mannose;
mannopyranose		metabolite
nopaline
nopaline: utilized by virulent strains of Agrobacterium; metabolites of crown-gall tumors; isonopaline refers to (R-isomer) of nopaline; structure. D-nopaline : An amino acid opine resulting from the formal reductive condensation of the amino group of L-arginine with the keto group of 2-oxopentanedioic acid.		3.1250amino acid opine;
D-glutamic acid derivative;
guanidines;
L-arginine derivative;
secondary amino compound;
tricarboxylic acid
octopine
D-octopine : The (1R)-1-carboxyethyl derivative of L-arginine. It is a metabolite released by plant tumours.		3.0950amino acid opine;
amino dicarboxylic acid;
D-alpha-amino acid zwitterion;
D-arginine derivative;
guanidines;
secondary amino compound		animal metabolite;
xenobiotic metabolite
agropine
agropine: RN given refers to (S)-isomer; structure given in first source		9.19170
mannopinic acid
mannopinic acid: mannityl opine analog; RN given refers to (S)-isomer		8.580
n-(3-oxo-octanoyl)-l-homoserine lactone
N-(beta-oxooctan-1-oyl)homoserine lactone: involved in conjugation and tra gene regulation in Agrobacterium tumefaciens; structure in first source		210
agropinic acid
agropinic acid: mannityl opine analog; RN given refers to (S)-isomer		3.2560
cucumopine
cucumopine: an opine from Agrobacterium vitis; RN given refers to cucumopine (4S-trans)-isomer; mikimopine is (4R-cis)-isomer		1.9910non-proteinogenic alpha-amino acid
puerarin
[no description available]		2.0110C-glycosyl compound;
isoflavonoid
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		1.9910organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9810
Chromosome Deletion
Actual loss of portion of a chromosome.		01.9710