Page last updated: 2024-12-07
mannopine
Description
Mannopine is a rare sugar derivative found in the bacterium Agrobacterium tumefaciens. It is synthesized by the bacterium as a byproduct of its infection of plants, specifically during the formation of crown gall tumors. The synthesis of mannopine involves the condensation of mannose and pyruvate, catalyzed by the enzyme mannopine synthase. This compound acts as a growth regulator in plants, influencing cell division and proliferation. It also serves as a specific signal molecule for Agrobacterium, allowing the bacterium to recognize and infect susceptible plants. The study of mannopine is crucial in understanding the mechanisms of plant-bacterial interactions, particularly the role of Agrobacterium in tumor formation and the development of plant genetic engineering techniques.'
mannopine: mannityl opine analog; RN given refers to (S)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
mannopine : A hexitol derivative that is D-mannitol in which the hydroxy group at position 1 is replaced by the alpha-amino group of L-glutamine. It is produced in crown gall tumours induced in a wide range of dicotyledenous plants by Agrobacterium tumefaciens. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 121864 |
| CHEBI ID | 80662 |
| SCHEMBL ID | 23388718 |
| MeSH ID | M0122656 |
Synonyms (12)
| Synonym |
|---|
| 87084-52-4 |
| mannopine |
| (2s)-5-amino-5-oxo-2-[[(2r,3r,4r,5r)-2,3,4,5,6-pentahydroxyhexyl]amino]pentanoic acid |
| d-mannitol, 1-((4-amino-1-carboxy-4-oxobutyl)amino)-1-deoxy-, (s)- |
| n(alpha)-(1-d-mannityl)-l-glutamine |
| n(2)-(1'-deoxy-d-mannitol-1'-yl)-l-glutamine |
| CHEBI:80662 |
| 1-{[(1s)-4-amino-1-carboxy-4-oxobutyl]amino}-1-deoxy-d-mannitol |
| DTXSID60236121 |
| mo0 , |
| Q27149704 |
| SCHEMBL23388718 |
Roles (1)
| Role | Description |
|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (6)
| Class | Description |
|---|
| hexitol derivative | An alditol derivative that is formally obtained from a hexitol. |
| dicarboxylic acid monoamide | |
| secondary amino compound | A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups. |
| amino acid opine | Any opine whose structure is based on the condensation of an amino acid with a carbohydrate or a keto-acid. |
| non-proteinogenic L-alpha-amino acid | Any L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids. |
| L-glutamine derivative | A proteinogenic amino acid derivative resulting from reaction of L-glutamine at the amino group, the carboxy group, or the carboxamide, or from the replacement of any hydrogen of L-glutamine by a heteroatom. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (39)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 6 (15.38) | 18.7374 |
| 1990's | 16 (41.03) | 18.2507 |
| 2000's | 11 (28.21) | 29.6817 |
| 2010's | 4 (10.26) | 24.3611 |
| 2020's | 2 (5.13) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 16.17
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 16.17 (24.57) | | Research Supply Index | 3.71 (2.92) | | Research Growth Index | 4.70 (4.65) | | Search Engine Demand Index | 10.37 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 40 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |