Page last updated: 2024-12-07

phospho-l-arginine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Phospho-L-arginine (PL-Arg) is a naturally occurring phosphorylated amino acid found in various organisms, including invertebrates and some vertebrates. It plays a crucial role in energy metabolism, serving as a high-energy phosphate donor similar to ATP. PL-Arg is synthesized through the phosphorylation of L-arginine by the enzyme arginine kinase. This compound is particularly important in invertebrates, where it acts as an energy reservoir during periods of high energy demand, such as muscle contraction. Research on PL-Arg focuses on its potential applications in various fields, including: 1. **Biomedical research**: Exploring its role in muscle function, particularly in the context of muscle fatigue and recovery. 2. **Therapeutic development**: Investigating its potential as a therapeutic agent for conditions like muscular dystrophy and heart failure. 3. **Sports nutrition**: Studying its effects on athletic performance, potentially improving muscle strength and endurance. PL-Arg is a fascinating molecule with diverse roles in biological systems. Its unique properties as an energy storage compound and its potential for therapeutic and athletic applications make it a subject of ongoing scientific inquiry.'

phospho-L-arginine: inhibits pyruvate kinase [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

N(omega)-phospho-L-arginine : An arginine derivative that is L-arginine substituted by a phosphono group at N(omega)-position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID92150
CHEBI ID18412
MeSH IDM0064681

Synonyms (30)

Synonym
phospho-l-arginine
(2s)-2-amino-5-{[imino(phosphonoamino)methyl]amino}pentanoic acid
CHEBI:18412
n(omega)-phosphono-l-arginine
n5-(imino(phosphonoamino)methyl)l-ornithine
phospho l-arginine
(2s)-2-amino-5-[(n-phosphonocarbamimidoyl)amino]pentanoic acid
omega-n-phosphoarginine
C05945
l-arginine-ng-phosphoric acid
1189-11-3
arginine phosphate
n(omega)-phospho-l-arginine
n5-[imino(phosphonoamino)methyl]l-ornithine
phosphoarginine a
einecs 214-714-7
AKOS022174911
(s)-2-amino-5-(3-phosphonoguanidino)pentanoic acid
RPI ,
phospho-arginine
(2s)-2-amino-5-(n'-phosphonocarbamimidamido)pentanoic acid
DTXSID10922805
n~5~-(n-phosphonocarbamimidoyl)ornithine
nw-phosphono-l-arginine
phospho-l-arginine (h-l-arg(po3h2)-oh)
mfcd09841186
Q27103062
CS-0441971
PD086649
(s)-2-amino-5-(3-phosphonoguanidino)pentanoicacid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
animal metaboliteAny eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
phosphoamino acid
phosphagenAny of a group of guanidine or amidine phosphates that function as storage depots for high-energy phosphate in muscle with the purpose of regenerating ATP from ADP during muscular contraction.
L-arginine derivativeA proteinogenic amino acid derivative resulting from reaction of L-arginine at the amino group, the carboxy group, or the guanidyl group, or from the replacement of any hydrogen of L-arginine by a heteroatom.
non-proteinogenic L-alpha-amino acidAny L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (90)

TimeframeStudies, This Drug (%)All Drugs %
pre-199030 (33.33)18.7374
1990's19 (21.11)18.2507
2000's22 (24.44)29.6817
2010's17 (18.89)24.3611
2020's2 (2.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 9.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index9.85 (24.57)
Research Supply Index4.57 (2.92)
Research Growth Index4.43 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (9.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews4 (4.17%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other92 (95.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]