Ejection Murmurs

Heart murmurs which are systolic in timing. They occur between the first and the second HEART SOUNDS, between the closure of MITRAL VALVE and TRICUSPID VALVE and the closure of semilunar aortic and pulmonary valves. Systolic murmurs include ejection murmurs and regurgitant murmurs.

Synonyms(3)

Synonym
Systolic Regurgitant Murmurs
Systolic Murmurs
Ejection Murmurs

Research Excerpts

Research

Studies (10)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	6 (60.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	1 (10.00)	18.1394
2010's	3 (30.00)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
nitrites	low	2
fentanyl	low	1
gentamicin	low	1
propofol	low	1
prednisolone	low	1
phenylephrine	low	1
ampicillin	low	1
n-pentyl nitrite	low	3
4-methoxyamphetamine	low	1
sulbactam	low	1
rocuronium	low	1
sultamicillin	low	1
gadolinium dtpa	low	1

Protein Targets (279)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	1	1	2
5-hydroxytryptamine receptor 2A	0	1	1	2
5-hydroxytryptamine receptor 1A	0	2	1	3
5-hydroxytryptamine receptor 1B	0	1	1	2
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	1	1	2
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	0	1	1
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	1	0	0	1
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	1	0	0	1
Beta-lactamase	0	0	0	1
acid sphingomyelinase	1	0	0	1
GLS protein	2	0	0	2
GLI family zinc finger 3	4	0	0	4
apical membrane antigen 1, AMA1	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	4	0	0	4
farnesoid X nuclear receptor	3	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
euchromatic histone-lysine N-methyltransferase 2	3	0	0	3
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
chromobox protein homolog 1	1	0	0	1
thyroid hormone receptor beta isoform 2	2	0	0	2
DNA polymerase beta	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
geminin	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
Carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
60 kDa heat shock protein, mitochondrial	0	1	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Solute carrier family 15 member 2	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	1	0	2
60 kDa chaperonin	0	1	0	1
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	1	0	1
Metallo-b-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	1	0	2
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase VIM-1	0	0	0	1
ATP-dependent phosphofructokinase	1	0	0	1
Luciferase	1	0	0	1
TDP1 protein	2	0	0	2
AR protein	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
pregnane X nuclear receptor	3	0	0	3
estrogen nuclear receptor alpha	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	1	0	1
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	3
D(3) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
glucocorticoid receptor [Homo sapiens]	3	0	0	3
estrogen-related nuclear receptor alpha	3	0	0	3
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
dopamine D1 receptor	1	0	0	1
glp-1 receptor, partial	1	0	0	1
thioredoxin reductase	1	0	0	1
NFKB1 protein, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
EWS/FLI fusion protein	1	0	0	1
Alpha-1B adrenergic receptor	0	0	1	1
D(1A) dopamine receptor	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	1
Alpha-2A adrenergic receptor	0	1	1	2
Beta-3 adrenergic receptor	0	0	1	1
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
luciferase	0	0	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
RAR-related orphan receptor gamma	2	0	0	2
progesterone receptor	3	0	0	3
aryl hydrocarbon receptor	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
ATP-binding cassette sub-family C member 3	0	2	0	2
Multidrug resistance-associated protein 4	0	2	0	2
Voltage-dependent calcium channel gamma-2 subunit	1	0	0	1
Bile salt export pump	0	2	0	2
Interferon beta	2	0	0	2
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	2	1	8
Cellular tumor antigen p53	3	0	0	3
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Cytochrome P450 2C9	0	1	0	1
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glutamate receptor 2	1	0	0	1
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
Estrogen receptor beta	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	2	0	2
ATPase family AAA domain-containing protein 5	1	0	0	1
Ataxin-2	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
USP1 protein, partial	1	0	0	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
G	1	0	0	1
caspase-3	1	0	0	1
activating transcription factor 6	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
Histone H2A.x	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
heat shock protein beta-1	1	0	0	1
cytochrome P450 3A4 isoform 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
lamin isoform A-delta10	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	1	1	1	3
UDP-glucuronosyltransferase 1A9	0	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	1	1	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit delta	1	1	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	1	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	1	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	1	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	1	1	1	3
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	1	1	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	1	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	1	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	1	1	3
Gamma-aminobutyric acid receptor subunit beta-3	1	1	1	3
Gamma-aminobutyric acid receptor subunit beta-2	1	1	1	3
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
GABA theta subunit	1	1	1	3
Inositol hexakisphosphate kinase 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	1	1	3
UDP-glucuronosyltransferase 1A8	0	0	0	1
cytochrome P450 2C9, partial	1	0	0	1
peripheral myelin protein 22	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
estrogen receptor 2 (ER beta)	1	0	0	1
retinoid X nuclear receptor alpha	2	0	0	2
peroxisome proliferator-activated receptor delta	1	0	0	1
peroxisome proliferator activated receptor gamma	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	1	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase SHV-1	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Beta-lactamase OXA-1	0	1	0	1
Beta-lactamase	0	1	0	1
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Beta-lactamase TEM	0	2	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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Ejection Murmurs

Synonyms(3)

Research Excerpts

Research

Studies (10)

Drugs Studied (15)

Protein Targets (279)