indolmycin profile

indolmycin: produced by a strain of Streptomyces griseus; RN given refers to cpd without isomeric designation; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

indolmycin : A member of the class of 1,3-oxazoles that is 1,3-oxazol-4(5H)-one which is substituted at the 2 and 5-pro-S positions by methylamino and [(1R)-1-(1H-indol-3-yl)ethyl] groups, respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	135417159
CHEMBL ID	417852
CHEBI ID	79394
SCHEMBL ID	117151
MeSH ID	M0041654

Synonym
pa 155 a
pa-155-a
indolmycin
2-oxazolin-4-one, 5-(1-indol-3-ylethyl)-2-(methylamino)-, (1r,5s)-(-)-
indolemycin
(1r,5s)-(-)-5-(1-indol-3-ylethyl)-2-(methylamino)-2-oxazolin-4-one
5-(1-indol-3-ylethyl)-2-(methylamino)-2-oxazolin-4-one
4(5h)-oxazolone, 5-(1-(1h-indol-3-yl)ethyl)-2-(methylamino)-, (s-(r,s))-
CHEMBL417852
chebi:79394 ,
indomycin
21200-24-8
(5s)-5-[(1r)-1-(1h-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4-one
unii-zmc93u2c8p
4(5h)-oxazolone, 5-((1r)-1-(1h-indol-3-yl)ethyl)-2-(methylamino)-, (5s)-
zmc93u2c8p ,
SCHEMBL117151
(5s)-5-[(1r)-1-(1h-indol-3-yl)ethyl]-2-(methylamino)-1,3-oxazol-4(5h)-one
(5s,6r)-(-)-indolmycin
(-)-indolmycin
tak-083
pa-155a
indolmycin [mi]
2-methylamino-5.alpha.-(.beta.-indolyl)ethyl-2-oxazolin-4-one
C21444
HY-117319
CS-0065292
indolemycin; indolmycin
Q27148430
GNTVWGDQPXCYBV-PELKAZGASA-N
(5s)-5-[(1r)-1-(1h-indol-3-yl)ethyl]-2-methylimino-1,3-oxazolidin-4-one
gtpl11021
DTXSID401318549
(5s)-5-[(1r)-1-(1h-indol-3-yl)ethyl]-2-(methylimino)-1,3-oxazolidin-4-one

Role	Description
antimicrobial agent	A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
EC 6.1.1.2 (tryptophan--tRNA ligase) inhibitor	An EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor that interferes with the action of any tryptophan--tRNA ligase (EC 6.1.1.2).
antibacterial agent	A substance (or active part thereof) that kills or slows the growth of bacteria.
bacterial metabolite	Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
1,3-oxazoles
secondary amino compound	A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups.
indoles	Any compound containing an indole skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (82)

Assay ID	Title	Year	Journal	Article
AID1132058	Antiviral activity against Coxsackievirus B1 infected in human HeLa cells by agar diffusion assay	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID1851783	Plasma protein binding in CD-1 mouse plasma incubated for 4 hrs at 2 uM measured by LC/MS/MS analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851764	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851763	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851780	Antibacterial activity against Enterococcus faecium EFM17-1 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560030	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 G(-13)T locus after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1132059	Cytotoxicity against human HeLa cells by neutral red assay	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID1851779	Antibacterial activity against Enterococcus faecalis ATCC 29212 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851758	Antibacterial activity against methicillin-resistant Staphylococcus aureus MRSA17-1 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851781	Antibacterial activity against Enterococcus faecium EFM17-2 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1132044	Antibacterial activity against Bacillus subtilis	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID1851782	Plasma protein binding in CD-1 mouse plasma incubated for 4 hrs and assessed as unbound fraction at 2 uM measured by LC/MS/MS analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560035	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 H48Q mutant ORF to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1132065	Antiviral activity against influenza A virus NWS/H0N1 infected in BHK cells at 1 mg/ml by agar diffusion assay	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID560034	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 L9F mutant ORF to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851775	Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis MSSE17-1 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560023	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 Q13K mutant ORF after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1466361	Antibacterial activity against Staphylococcus aureus	2017	European journal of medicinal chemistry, Jul-07, Volume: 134	Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.
AID560033	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 ORF to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560047	Ratio of MIC for Streptomyces coelicolor B725 overexpressing tryptophanyl-tRNA synthetase gene to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851753	Antibacterial activity against vancomycin-intermediate Staphylococcus aureus measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851785	Stability in CD-1 mouse whole blood assessed as compound remaining at 2 uM and measured at 10 mins LC-MS/MS analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560038	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 L9F/Q13K mutant ORF to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560041	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 C(-17)A locus to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851769	Antibacterial activity against methicillin-sensitive Staphylococcus aureus MSSA17-3 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560037	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 Q13K mutant ORF to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1132049	Antibacterial activity against Streptococcus pyogenes CN10	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID560017	Antimicrobial activity against Streptomyces avermitilis harboring trpRS1 homolog after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560014	Antimicrobial activity against wild-type Streptomyces coelicolor after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560032	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 G(-13)T/H48Q locus after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1132056	Antiviral activity against influenza A virus NWS/H0N1 infected in BHK cells by agar diffusion assay	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID1851770	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis MRSE17-1 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560022	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 H48N mutant ORF after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1132047	Antibacterial activity against Staphylococcus aureus 1517	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID1132046	Antibacterial activity against Staphylococcus aureus Russel	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID560043	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 C(-17)A/H48Q locus to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851777	Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis MSSE17-3 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560044	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 G(-13)T locus to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560020	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 L9F mutant ORF after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560028	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 C(-17)A/L9F locus after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851787	Stability in CD-1 mouse whole blood assessed as compound remaining at 2 uM and measured at 60 mins LC-MS/MS analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851767	Antibacterial activity against methicillin-sensitive Staphylococcus aureus MSSA17-1 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560029	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 C(-17)A/H48Q locus after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560039	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 L9F/H48Q mutant ORF to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560045	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 G(-13)T/L9F locus to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560019	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 ORF after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851773	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis MRSE17-4 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851771	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis MRSE17-2 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1466362	Antibacterial activity against Helicobacter pylori	2017	European journal of medicinal chemistry, Jul-07, Volume: 134	Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view.
AID560042	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 C(-17)A/L9F locus to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1132045	Antibacterial activity against Staphylococcus aureus Oxford	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID560040	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 locus to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851786	Stability in CD-1 mouse whole blood assessed as compound remaining at 2 uM and measured at 30 mins LC-MS/MS analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851761	Antibacterial activity against methicillin-resistant Staphylococcus aureus MRSA17-5 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1132048	Antibacterial activity against Streptococcus faecalis I	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID560021	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 H48Q mutant ORF after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851765	Antibacterial activity against vancomycin-intermediate Staphylococcus aureus ATCC 700699 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851776	Antibacterial activity against methicillin-sensitive Staphylococcus epidermidis MSSE17-2 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851759	Antibacterial activity against methicillin-resistant Staphylococcus aureus MRSA17-2 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560031	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 G(-13)T/L9F locus after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851766	Antibacterial activity against vancomycin-intermediate Staphylococcus aureus ATCC 700788 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851772	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis MRSE17-3 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560036	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 H48N mutant ORF to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851768	Antibacterial activity against methicillin-sensitive Staphylococcus aureus MSSA17-2 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560026	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 locus after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851774	Antibacterial activity against methicillin-resistant Staphylococcus epidermidis MRSE17-6 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560046	Ratio of MIC for Streptomyces coelicolor B725 harboring trpRS2 G(-13)T/H48Q locus to MIC for Streptomyces coelicolor B725	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560018	Antimicrobial activity against Streptomyces griseus after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560025	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 L9F/H48Q mutant ORF after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1132066	Antiviral activity against Coxsackievirus B1 infected in human HeLa cells at 1 mg/ml by agar diffusion assay	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID1851762	Antibacterial activity against methicillin-resistant Staphylococcus aureus MRSA17-6 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851754	Antibacterial activity against Helicobacter pylori measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851778	Antibacterial activity against Enterococcus faecalis EFA17-1 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851784	Drug recovery in CD-1 mouse plasma incubated for 4 hrs at 2 uM measured by LC/MS/MS analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1851760	Antibacterial activity against methicillin-resistant Staphylococcus aureus MRSA17-3 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560024	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 L9F/Q13K mutant ORF after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID1851788	Stability in CD-1 mouse whole blood assessed as compound remaining at 2 uM and measured at 120 mins LC-MS/MS analysis	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID1132057	Cytotoxicity against BHK cells	1978	Journal of medicinal chemistry, Jan, Volume: 21, Issue:1	Thiazolinone analogues of indolmycin with antiviral and antibacterial activity.
AID1851756	Antibacterial activity against Staphylococcus aureus ATCC 29213 measured by liquid dilution method	2022	European journal of medicinal chemistry, Nov-05, Volume: 241	Design, synthesis, and antibacterial activity of derivatives of Tryptophanyl-tRNA synthetase inhibitor indolmycin.
AID560016	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS1 ORF after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560027	Antimicrobial activity against Streptomyces coelicolor B725 harboring trpRS2 C(-17)A locus after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
AID560015	Antimicrobial activity against trpRS1 deficient Streptomyces coelicolor B725 after 48 hrs	2009	Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9	A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	8 (30.77)	18.7374
1990's	1 (3.85)	18.2507
2000's	5 (19.23)	29.6817
2010's	8 (30.77)	24.3611
2020's	4 (15.38)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	3 (11.54%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	23 (88.46%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
dimethyl sulfoxide Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.	1.95	1	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	3.06	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
oxyquinoline Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.	2.06	1	monohydroxyquinoline	antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.06	1	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
juglone juglone: structure. juglone : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogen at position 5 has been replaced by a hydroxy group. A plant-derived 1,4-naphthoquinone with confirmed antibacterial and antitumor activities.	2.06	1	hydroxy-1,4-naphthoquinone	geroprotector; herbicide; reactive oxygen species generator
2-hydroxybenzylbenzimidazole 2-hydroxybenzylbenzimidazole: RN given refers to cpd without isomeric designation	1.95	1
leucine Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.	2.25	1	amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	8.46	2	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2.05	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	1.95	1	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	3.71	10	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
thiazoles [no description available]	3.49	2	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
propantheline bromide [no description available]	2.41	1	xanthenes
violacein [no description available]	2.07	1
vancomycin Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.	2.41	1	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	3.06	1	dihydrogen
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	3.06	1	benzenes; phenyl acetates
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.	3.25	1	azide; pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
ribavirin Rebetron: Rebetron is tradename	1.95	1	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
swainsonine Swainsonine: An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.. swainsonine : An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8.	2.07	1	indolizidine alkaloid	antineoplastic agent; EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor; immunological adjuvant; plant metabolite
cryptolepine cryptolepine: fused indole-quinoline; structure in first source; from CRYPTOLEPIS sanguinolenta. cryptolepine : An organic heterotetracyclic compound that is 5H-indolo[3,2-b]quinoline in which the hydrogen at position N-5 is replaced by a methyl group.	3.25	1	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound	anti-inflammatory agent; antimalarial; antineoplastic agent; cysteine protease inhibitor; plant metabolite
canthin-6-one canthin-6-one: from Zanthoxylum usambarense; structure in first source. canthin-6-one : An indole alkaloid that is 6H-indolo[3,2,1-de][1,5]naphthyridine substituted by an oxo group at position 6.	3.25	1	enone; indole alkaloid; organic heterotetracyclic compound	antimycobacterial drug; metabolite
4-iodophenylalanine 4-iodophenylalanine: RN given refers to cpd without isomeric designation. 4-iodophenylalanine : A phenylalanine derivative that is phenylalanine carrying an iodo group at position 4 on the benzene ring.	2.05	1	4-iodophenylalanine
cryptolepine monohydrochloride [no description available]	3.25	1
uleine uleine: from the bark of Plumeria lancifolia; structure in first source	3.25	1
neocryptolepine neocryptolepine: isolated from the roots of the African plant Cryptolepis sanguinolenta; structure in first source	3.25	1
mupirocin Mupirocin: A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.. mupirocin : An alpha,beta-unsaturated ester resulting from the formal condensation of the alcoholic hydroxy group of 9-hydroxynonanoic acid with the carboxy group of (2E)-4-[(2S)-tetrahydro-2H-pyran-2-yl]-3-methylbut-2-enoic acid in which the tetrahydropyranyl ring is substituted at positions 3 and 4 by hydroxy groups and at position 5 by a {(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl}methyl group. Originally isolated from the Gram-negative bacterium Pseudomonas fluorescens, it is used as a topical antibiotic for the treatment of Gram-positive bacterial infections.	2.71	3	alpha,beta-unsaturated carboxylic ester; epoxide; monocarboxylic acid; oxanes; secondary alcohol; triol	antibacterial drug; bacterial metabolite; protein synthesis inhibitor
oxazolone Oxazolone: Immunologic adjuvant and sensitizing agent.	2.11	1
fusidic acid Fusidic Acid: An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.. fusidic acid : A steroid antibiotic that is isolated from the fermentation broth of Fusidium coccineum.	2.02	1	11alpha-hydroxy steroid; 3alpha-hydroxy steroid; alpha,beta-unsaturated monocarboxylic acid; steroid acid; steroid antibiotic; sterol ester	EC 2.7.1.33 (pantothenate kinase) inhibitor; Escherichia coli metabolite; protein synthesis inhibitor
chuangxinmycin chuangxinmycin: produced by Actinoplanes tsinanensis; structure. (-)-chuangxinmycin : A thiinoindole that is 3,5-dihydro-2H-thiino[4,3,2-cd]indole which is substituted at positions 2 and 3 by carboxy and methyl groups, respectively (the 2R,3S diastereoisomer).	2.45	2	indole alkaloid; monocarboxylic acid; thiinoindole	antibacterial agent; antimicrobial agent; bacterial metabolite; EC 6.1.1.2 (tryptophan--tRNA ligase) inhibitor
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	2.06	1
myxothiazol myxothiazol: strobilurin analogue; methoxyacrylamide derivative; antifungal antibiotic from Myxococcus fulvus; structure given in first source. myxothiazol : A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S,3E,5E)-7-methylocta-3,5-dien-2-yl group. It is an inhibitor of coenzyme Q - cytochrome c reductase.	3.16	1
oudemansin oudemansin: strong antifungal properties & inhibits respiration in fungi, cells of ascitic form of EHRLICH carcinoma & rat liver mitochondria; structure; biological activity depends on methoxyacrylate moiety	3.16	1	styrenes
laq824 LAQ824: Histone deacetylase inhibitor	3.25	1
manzamine a manzamine A: RN given refers to (1R-(1R,9Z,13S,13aR,20aR,21aR*)-isomer; RN for cpd without isomeric designation not avail 12/92. manzamine A : An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).	3.25	1	alkaloid; beta-carbolines; isoquinolines	animal metabolite; anti-HSV-1 agent; antimalarial; antineoplastic agent; EC 2.7.11.26 (tau-protein kinase) inhibitor; marine metabolite
pf-562,271 [no description available]	3.25	1	indoles
nad NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.	3.06	1	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite
borrelidin treponemycin: isolated from Streptomyces albovinaceous; active against Treponema hyodysenteriae. borrelidin : A macrolide that is isolated from several Streptomyces species and displays antibiotic, antineoplastic and antimalarial properties.	2.06	1	aliphatic nitrile; diol; macrolide; monocarboxylic acid; secondary alcohol	antifungal agent; antimalarial; antimicrobial agent; antineoplastic agent; apoptosis inducer; bacterial metabolite
4-epianhydrotetracycline 4-epianhydrotetracycline: impurity in pahrmaceutical preparations of tetracycline; RN refers to (4S-(4alpha,4aalpha,12aalpha))-isomer	2.06	1
warfarin Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.	2.41	1	benzenes; hydroxycoumarin; methyl ketone
guanosine pentaphosphate Guanosine Pentaphosphate: Guanosine 5'-triphosphate 2'(3')-diphosphate. A guanine nucleotide containing five phosphate groups. Three phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids are not available for protein synthesis.. guanosine 3'-diphosphate 5'-triphosphate : A guanosine bisphosphate having a diphosphate at the 3'-position and a triphosphate at the 5'-position.	1.98	1	guanosine 5'-phosphate; guanosine bisphosphate	Escherichia coli metabolite; mouse metabolite
guanosine tetraphosphate Guanosine Tetraphosphate: Guanosine 5'-diphosphate 2'(3')-diphosphate. A guanine nucleotide containing four phosphate groups. Two phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids are not available for protein synthesis. Synonym: magic spot I.. guanosine 3',5'-bis(diphosphate) : A guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions.	1.98	1	guanosine bisphosphate	Escherichia coli metabolite; mouse metabolite
trigonoliimine a trigonoliimine A: from the leaves of Trigonostemon lii; structure in first source	3.25	1

Condition	Relationship Strength	Studies
Bacterial Disease [description not available]	3.06	1
Abdominal Migraine [description not available]	3.06	1
Fungal Diseases [description not available]	3.06	1
Benign Neoplasms [description not available]	3.06	1
Viral Diseases [description not available]	3.06	1
Bacterial Infections Infections by bacteria, general or unspecified.	3.06	1
Migraine Disorders A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)	3.06	1
Mycoses Diseases caused by FUNGI.	3.06	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.06	1
Virus Diseases A general term for diseases caused by viruses.	3.06	1
Infections, Chlamydia [description not available]	2.25	1
Chlamydia Infections Infections with bacteria of the genus CHLAMYDIA.	2.25	1
Infections, Staphylococcal [description not available]	2.02	1
Staphylococcal Infections Infections with bacteria of the genus STAPHYLOCOCCUS.	7.02	1

indolmycin

Description

Cross-References

Synonyms (34)

Roles (4)

Drug Classes (3)

Bioassays (82)

Research

Studies (26)

Study Types

indolmycin

Description

Cross-References

Synonyms (34)

Roles (4)

Drug Classes (3)

Bioassays (82)

Research

Studies (26)

Study Types

Related Drugs (43)

Related Conditions (14)