hypothemycin and Leukemia-P388

hypothemycin has been researched along with Leukemia-P388* in 1 studies

Other Studies

1 other study(ies) available for hypothemycin and Leukemia-P388

ArticleYear
Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus.
    The Journal of organic chemistry, 2002, Mar-08, Volume: 67, Issue:5

    Aigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC(50) values of 2.2 and 6.6 microg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.

    Topics: Animals; Anti-Bacterial Agents; Antimalarials; Antineoplastic Agents; Antiprotozoal Agents; Ascomycota; Botrytis; Breast Neoplasms; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Colonic Neoplasms; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Female; Humans; Inhibitory Concentration 50; KB Cells; Kidney; Leukemia; Leukemia P388; Macrolides; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum; Tetrahymena; Thailand; Ustilago; Vero Cells; Zearalenone

2002