hypothemycin and monorden

hypothemycin has been researched along with monorden* in 3 studies

Reviews

1 review(s) available for hypothemycin and monorden

ArticleYear
Chemistry and biology of resorcylic acid lactones.
    Chemical communications (Cambridge, England), 2007, Jan-07, Issue:1

    While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.

    Topics: HSP90 Heat-Shock Proteins; Hydroxybenzoates; Lactones; Macrocyclic Compounds; Macrolides; Mitogen-Activated Protein Kinases; Molecular Structure; Mycotoxins; Zearalenone

2007

Other Studies

2 other study(ies) available for hypothemycin and monorden

ArticleYear
Antifungal and Cytotoxic β-Resorcylic Acid Lactones from a Paecilomyces Species.
    Journal of natural products, 2017, 08-25, Volume: 80, Issue:8

    Eight new β-resorcylic acid lactones (RALs), including the hypothemycin-type compounds paecilomycins N-P (1-3) and the radicicol-type metabolites dechloropochonin I (4), monocillins VI (5) and VII (6), 4'-hydroxymonocillin IV (7), and 4'-methoxymonocillin IV (8), along with nine known RALs (9-17), were isolated from the cultures of Paecilomyces sp. SC0924. Compounds 1 and 2 feature a novel 6/11/5 ring system, and 3 is the first 5'-keto RAL. The structures of 1-8 were elucidated on the basis of extensive spectroscopic analysis, X-ray diffraction analysis, and theoretical calculations of ECD spectra. Compounds 3, 5, and 6 exhibit cytotoxicity against MCF-7, A549, and HeLa cells, and compounds 5 and 7 display antifungal activity against Peronophythora litchii.

    Topics: Antifungal Agents; HeLa Cells; Humans; Hydroxybenzoate Ethers; Hydroxybenzoates; Lactones; Macrolides; Molecular Structure; Paecilomyces; Phytophthora; X-Ray Diffraction; Zearalenone

2017
Genes for the biosynthesis of the fungal polyketides hypothemycin from Hypomyces subiculosus and radicicol from Pochonia chlamydosporia.
    Applied and environmental microbiology, 2008, Volume: 74, Issue:16

    Gene clusters for biosynthesis of the fungal polyketides hypothemycin and radicicol from Hypomyces subiculosus and Pochonia chlamydosporia, respectively, were sequenced. Both clusters encode a reducing polyketide synthase (PKS) and a nonreducing PKS like those in the zearalenone cluster of Gibberella zeae, plus enzymes with putative post-PKS functions. Introduction of an O-methyltransferase (OMT) knockout construct into H. subiculosus resulted in a strain with increased production of 4-O-desmethylhypothemycin, but because transformation of H. subiculosus was very difficult, we opted to characterize hypothemycin biosynthesis using heterologous gene expression. In vitro, the OMT could methylate various substrates lacking a 4-O-methyl group, and the flavin-dependent monooxygenase (FMO) could epoxidate substrates with a 1',2' double bond. The glutathione S-transferase catalyzed cis-trans isomerization of the 7',8' double bond of hypothemycin. Expression of both hypothemycin PKS genes (but neither gene alone) in yeast resulted in production of trans-7',8'-dehydrozearalenol (DHZ). Adding expression of OMT, expression of FMO, and expression of cytochrome P450 to the strain resulted in methylation, 1',2'-epoxidation, and hydroxylation of DHZ, respectively. The radicicol gene cluster encodes halogenase and cytochrome P450 homologues that are presumed to catalyze chlorination and epoxidation, respectively. Schemes for biosynthesis of hypothemycin and radicicol are proposed. The PKSs encoded by the two clusters described above and those encoded by the zearalenone cluster all synthesize different products, yet they have significant sequence identity. These PKSs may provide a useful system for probing the mechanisms of fungal PKS programming.

    Topics: Base Sequence; Cloning, Molecular; DNA, Fungal; Escherichia coli; Gene Expression Regulation, Fungal; Genes, Fungal; Genetic Vectors; Genomic Library; Hypocreales; Macrolides; Molecular Sequence Data; Multigene Family; Polyketide Synthases; Saccharomyces cerevisiae; Sequence Analysis, DNA; Zearalenone

2008