Page last updated: 2024-10-24

positive regulation of embryonic development

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of embryonic development. [GOC:go_curators]

Positive regulation of embryonic development encompasses a complex and tightly regulated series of events that orchestrate the transformation of a single fertilized egg into a multicellular organism. This process involves a precise interplay of genetic and environmental factors, ensuring the proper formation and differentiation of tissues and organs. Key aspects of positive regulation of embryonic development include:

1. **Maternal contribution**: The egg cell provides essential factors, including mRNA transcripts, proteins, and other molecules, which are critical for early stages of development. These maternal factors establish the initial developmental axes and initiate the process of cell division.

2. **Zygotic genome activation**: As the embryo develops, the zygotic genome becomes active, allowing for the expression of genes that regulate subsequent developmental events. This transition marks the beginning of embryonic gene regulation.

3. **Cell division and differentiation**: Embryonic cells undergo rapid and controlled cell division, leading to an increase in cell number. Simultaneously, these cells differentiate into specialized cell types, forming the various tissues and organs of the organism.

4. **Morphogenesis**: The process of morphogenesis involves the coordinated movement and organization of cells, leading to the formation of specific structures and body shapes. This process is driven by cell-cell interactions, signaling pathways, and cytoskeletal rearrangements.

5. **Organogenesis**: The formation of distinct organs occurs during organogenesis, which involves the interaction of multiple cell types and the coordinated development of specific tissues.

6. **Growth and maturation**: After the formation of organs, the embryo continues to grow and mature, reaching a stage where it can function independently.

7. **Regulation by signaling pathways**: Numerous signaling pathways, such as the Wnt, Hedgehog, and TGF-beta pathways, play critical roles in regulating embryonic development. These pathways control cell fate decisions, cell division, and cell migration.

8. **Transcriptional regulation**: Transcription factors bind to specific DNA sequences, activating or repressing the expression of genes that control developmental processes.

9. **Post-transcriptional regulation**: Processes such as RNA splicing, mRNA translation, and protein stability contribute to the precise regulation of gene expression during development.

10. **Environmental influences**: Environmental factors, such as temperature, nutrient availability, and oxygen levels, can influence embryonic development.

These intricate processes are highly coordinated and tightly regulated, ensuring the successful development of a healthy organism. Disruptions in any of these processes can lead to developmental defects and diseases.'
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Proteins (3)

ProteinDefinitionTaxonomy
Prostaglandin G/H synthase 2 A prostaglandin G/H synthase 2 that is encoded in the genome of cow. [OMA:O62698, PRO:DNx]Bos taurus (cattle)
Nuclear receptor subfamily 2 group C member 2A nuclear receptor subfamily 2 group C member 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P49116]Homo sapiens (human)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NQ66]Homo sapiens (human)

Compounds (27)

CompoundDefinitionClassesRoles
amfenacamfenac : An oxo monocarboxylic acid that is benzophenone in which one of the phenyl groups is substituted by an amino group and a carboxymethyl group at position 2 and 3, respectively. The corresponding carboxamide, nepafenac, is a prodrug of amfenac and is used for the treatment of pain and inflammation following cataract surgery.

amfenac: RN given refers to parent cpd; structure
amino acid;
benzophenones;
oxo monocarboxylic acid;
primary amino compound;
substituted aniline
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
aspirinacetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.

acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.

Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
benzoic acids;
phenyl acetates;
salicylates
anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent
celecoxiborganofluorine compound;
pyrazoles;
sulfonamide;
toluenes
cyclooxygenase 2 inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
ibuprofenMidol: combination of cinnamedrine, phenacetin, aspirin & caffeinemonocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
indomethacinindometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole
analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic;
xenobiotic metabolite
ketoconazole1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
masoprocolnordihydroguaretic acid: antioxidant compound found in the creosote bush (Larrea tridentata)catechols;
lignan;
tetrol
antioxidant;
ferroptosis inhibitor;
geroprotector;
plant metabolite
rofecoxibbutenolide;
sulfone
analgesic;
cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug
zomepiraczomepirac: RN given refers to parent cpd; structurearomatic ketone;
monocarboxylic acid;
monochlorobenzenes;
pyrroles
cardiovascular drug;
non-steroidal anti-inflammatory drug
1-naphthol1-naphthol : A naphthol carrying a hydroxy group at position 1.

1-naphthol: RN given refers to parent cpd

hydroxynaphthalene : Any member of the class of naphthalenes that is naphthalene carrying one or more hydroxy groups.
naphtholgenotoxin;
human xenobiotic metabolite
phenidonephenidone: photographic developer; RN given refers to parent cpd; structure
proquazoneproquazone: nonsteroid anti-inflammatory agent; structurepyrimidines
lonapaleneRS 43179: used in treatment of psoriasisnaphthalenes;
organochlorine compound
zileuton1-benzothiophenes;
ureas
anti-asthmatic drug;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
ferroptosis inhibitor;
leukotriene antagonist;
non-steroidal anti-inflammatory drug
1,2-hexanoylphosphatidylcholine1,2-hexanoylphosphatidylcholine: RN given refers to cpd without isomeric designation
ilomastatCS 610: matrix metalloproteinase inhibitor; structure in first source

ilomastat : An N-acyl-amino acid obtained by formal condensation of the carboxy group of (2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the amino group of N-methyl-L-tryptophanamide. A cell permeable broad-spectrum matrix metalloproteinase (MMP) inhibitor
hydroxamic acid;
L-tryptophan derivative;
N-acyl-amino acid
anti-inflammatory agent;
antibacterial agent;
antineoplastic agent;
EC 3.4.24.24 (gelatinase A) inhibitor;
neuroprotective agent
ml-3000
2-(phenylmethyl)-1-naphthol2-(phenylmethyl)-1-naphthol: structure in UD
dinoprostDinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.

prostaglandin F2alpha : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.
monocarboxylic acid;
prostaglandins Falpha
human metabolite;
mouse metabolite
cloprostenolCloprostenol: A synthetic prostaglandin F2alpha analog. The compound has luteolytic effects and is used for the synchronization of estrus in cattle.prostanoid
l 651896L 651896: structure given in first source
16,16-dimethylprostaglandin f2alpha16,16-dimethylprostaglandin F2alpha: RN given refers to (5Z,9alpha,11alpha,13E,15R)-isomer
fr 1480835Z-7-oxozeaenol : A macrolide that is the 7-oxo derivative of zeaenol (the 5Z stereoisomer). Isolated from Fungi, it exhibits cytotoxic, antibacterial and inhibitory activity against NF-kappaB.aromatic ether;
macrolide;
phenols;
secondary alcohol;
secondary alpha-hydroxy ketone
antibacterial agent;
antineoplastic agent;
metabolite;
NF-kappaB inhibitor
hypothemycinhypothemycin : A macrolide that is isolated from the cultured broth of Hypomyces subiculosus and shows antifungal activity and inhibits the growth of some human cancer cells.

hypothemycin: a resorcylic acid lactone antibiotic; antifungal metabolite from Hypomyces trichothecoides
aromatic ether;
diol;
enone;
epoxide;
macrolide;
phenols;
polyketide;
secondary alpha-hydroxy ketone
antifungal agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
fungal metabolite
tak 285N-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo(3,2-d)pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide: also inhibits HER2; structure in first source
ahr 5850sodium (2-amino-3-benzoylphenyl)acetate : An organic sodium salt having amfenac(1-) as the counterion.organic sodium saltcyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor
piroxicambenzothiazine;
monocarboxylic acid amide;
pyridines
analgesic;
antirheumatic drug;
cyclooxygenase 1 inhibitor;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
non-steroidal anti-inflammatory drug